ID   GOP1_CAEEL              Reviewed;         892 AA.
AC   P46578;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein CLEC16A homolog {ECO:0000305};
GN   Name=gop-1; ORFNames=C34E10.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Regulator of mitophagy. {ECO:0000250|UniProtKB:Q80U30}.
CC   -!- SIMILARITY: Belongs to the CLEC16A/gop-1 family. {ECO:0000305}.
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DR   EMBL; FO080774; CCD66647.1; -; Genomic_DNA.
DR   PIR; T15760; T15760.
DR   RefSeq; NP_498117.3; NM_065716.4.
DR   AlphaFoldDB; P46578; -.
DR   SMR; P46578; -.
DR   BioGRID; 40952; 2.
DR   STRING; 6239.C34E10.3; -.
DR   EPD; P46578; -.
DR   PaxDb; P46578; -.
DR   PeptideAtlas; P46578; -.
DR   PRIDE; P46578; -.
DR   EnsemblMetazoa; C34E10.3.1; C34E10.3.1; WBGene00001660.
DR   GeneID; 175721; -.
DR   KEGG; cel:CELE_C34E10.3; -.
DR   UCSC; C34E10.3; c. elegans.
DR   CTD; 175721; -.
DR   WormBase; C34E10.3; CE01183; WBGene00001660; gop-1.
DR   eggNOG; KOG2219; Eukaryota.
DR   GeneTree; ENSGT00390000013826; -.
DR   HOGENOM; CLU_007413_1_0_1; -.
DR   InParanoid; P46578; -.
DR   OMA; FMFDDHI; -.
DR   OrthoDB; 1319544at2759; -.
DR   PhylomeDB; P46578; -.
DR   PRO; PR:P46578; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00001660; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0036020; C:endolysosome membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR   GO; GO:1901096; P:regulation of autophagosome maturation; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039272; CLEC16A/TT9.
DR   InterPro; IPR019155; CLEC16A/TT9_N.
DR   InterPro; IPR045820; CLEC16A_C.
DR   PANTHER; PTHR21481; PTHR21481; 1.
DR   Pfam; PF19439; CLEC16A_C; 1.
DR   Pfam; PF09758; FPL; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Autophagy; Reference proteome.
FT   CHAIN           1..892
FT                   /note="Protein CLEC16A homolog"
FT                   /id="PRO_0000065223"
FT   DOMAIN          48..194
FT                   /note="FPL"
FT                   /evidence="ECO:0000255"
FT   REGION          844..892
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        845..885
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  100861 MW;  B49FE29FFDDDD930 CRC64;
     MFRKLGSSGS LWKPKNPHSL EYLKYLQGVL TKNEKVTENN KKILVEALRA IAEILIWGDQ
     NDASVFDFFL ERQMLLYFLK IMEQGNTPLN VQLLQTLNIL FENIRHETSL YFLLSNNHVN
     SIISHKFDLQ NDEIMAYYIS FLKTLSFKLN PATIHFFFNE TTEEFPLLVE VLKLYNWNES
     MVRIAVRNIL LNIVRVQDDS MIIFAIKHTK EYLSELIDSL VGLSLEMDTF VRSAENVLAN
     RERLRGKVDD LIDLIHYIGE LLDVEAVAES LSILVTTRYL SPLLLSSISP RRDNHSLLLT
     PISALFFFSE FLLIVRHHET IYTFLSSFLF DTQNTLTTHW IRHNEKYCLE PITLSSPTGE
     YVNEDHVFFD FLLEAFDSSQ ADDSKAFYGL MLIYSMFQNN ADVGELLSAA NFPVLKESTT
     TSLAQQNLAR LRIASTSSIS KRTRAITEIG VEATEEDEIF HDVPEEQTLE DLVDDVLVDT
     ENSAISDPEP KNVESESRSR FQSAVDELPP PSTSGCDGRL FDALSSIIKA VGTDDNRIRP
     ITLELACLVI RQILMTVDDE KVHTSLTKLC FEVRLKLLSS IGQYVNGENL FLEWFEDEYA
     EFEVNHVNFD IIGHEMLLPP AATPLSNLLL HKRLPSGFEE RIRTQIVFYL HIRKLERDLT
     GEGDTELPVR VLNSDQEPVA IGDCINLHNS DLLSCTVVPQ QLCSLGKPGD RLARFLVTDR
     LQLILVEPDS RKAGWAIVRF VGLLQDTTIN GDSTDSKVLH VVVEGQPSRI KKRHPVLTAK
     FIFDDHIRCM AAKQRLTKGR QTARGLKLQA ICSALGVPRI DPATMTSSPR MNPFRIVKGC
     APGSVRKTVS TSSSSSQGRP GHYSANLRSA SRNAGMIPDD PTQPSSSSER RS