ID   GORAB_RAT               Reviewed;         368 AA.
AC   B1H222; Q5RK15;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=RAB6-interacting golgin;
DE   AltName: Full=N-terminal kinase-like-binding protein 1;
DE            Short=NTKL-BP1;
DE            Short=NTKL-binding protein 1;
DE   AltName: Full=SCY1-like 1-binding protein 1;
DE            Short=SCYL1-BP1;
DE            Short=SCYL1-binding protein 1;
GN   Name=Gorab; Synonyms=Ntklbp1, Scyl1bp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with RCHY1, RAB6A/RAB6 and SCYL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5T7V8}. Golgi
CC       apparatus {ECO:0000250|UniProtKB:Q5T7V8}.
CC   -!- SIMILARITY: Belongs to the GORAB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI60825.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC086370; AAH86370.1; -; mRNA.
DR   EMBL; BC160825; AAI60825.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001094033.1; NM_001100563.1.
DR   AlphaFoldDB; B1H222; -.
DR   SMR; B1H222; -.
DR   STRING; 10116.ENSRNOP00000005148; -.
DR   PaxDb; B1H222; -.
DR   PeptideAtlas; B1H222; -.
DR   PRIDE; B1H222; -.
DR   Ensembl; ENSRNOT00000005148; ENSRNOP00000005148; ENSRNOG00000003861.
DR   GeneID; 304923; -.
DR   KEGG; rno:304923; -.
DR   UCSC; RGD:1564990; rat.
DR   CTD; 92344; -.
DR   RGD; 1564990; Gorab.
DR   eggNOG; ENOG502R60M; Eukaryota.
DR   GeneTree; ENSGT00390000014886; -.
DR   HOGENOM; CLU_064636_0_0_1; -.
DR   InParanoid; B1H222; -.
DR   OMA; PMAQGWA; -.
DR   OrthoDB; 1277705at2759; -.
DR   PhylomeDB; B1H222; -.
DR   TreeFam; TF324839; -.
DR   PRO; PR:B1H222; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003861; Expressed in ovary and 19 other tissues.
DR   Genevisible; B1H222; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031069; P:hair follicle morphogenesis; ISO:RGD.
DR   GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR   GO; GO:1901622; P:positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; ISO:RGD.
DR   InterPro; IPR007033; GORAB.
DR   PANTHER; PTHR21470; PTHR21470; 1.
DR   Pfam; PF04949; Transcrip_act; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Golgi apparatus; Reference proteome.
FT   CHAIN           1..368
FT                   /note="RAB6-interacting golgin"
FT                   /id="PRO_0000367459"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..368
FT                   /note="Necessary for interaction with RCHY1"
FT                   /evidence="ECO:0000250"
FT   REGION          298..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          145..304
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        10..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..334
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  41632 MW;  361BB58FB0A1AF15 CRC64;
     MAQGWAGFSE EELRRLKQNK DPFEPQRRLP VKKTRQQLQR EKALLEQSQK LGLQDGSASL
     LPEQLLSTPK QRASSQKPPP SSPAVPSPLT LTSSTGDGEL HGGESQLQEP GLENSHHGSR
     SAEIQTPKPD CKVEKKKMEL QEKSRWEVLQ QEQRLMEEKN KRKKALLAQA IAERSRRTQA
     ETMKLKRIQK ELQALDDMVS ADIGILRNRI DQASLEYSYA RKRFDRAEAE YVTAKLDLQR
     KTETKEQLTE HLCTIIQQNE LRKAQKLEEL MRQLDVQADD EALELELEVE QLLREQEAEA
     ARQMAPVERL SQPDGEGVSS ELTEENKEPQ KPATSPETDK SGKCCSSSPR RLDCPDPGAQ
     NFPAAVAT