GOR_HUMAN
ID GOR_HUMAN Reviewed; 675 AA.
AC Q8IX06; A6NK34; O95107;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Putative exonuclease GOR;
DE EC=3.1.-.-;
DE AltName: Full=Antigen GOR homolog;
DE AltName: Full=RNA exonuclease 1 homolog-like 1;
GN Name=REXO1L1P; Synonyms=GOR, REXO1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 154-675.
RC TISSUE=Liver;
RA Gomez-Gonzalez O., Rodriguez R.E., Gonzalez-Sarmiento R.;
RT "A mariner transposon is located near the human GOR gene.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 490-658.
RA DeBella L.R., Schertzer M., Wood S.;
RT "Identification of a novel human gene (GOR) localized to 8q13-8q22.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX PubMed=11472404; DOI=10.1046/j.1365-2249.2001.01508.x;
RA Koike R., Iizuka T., Watanabe T., Miyasaka N.;
RT "The GOR gene product cannot cross-react with hepatitis C virus in
RT humans.";
RL Clin. Exp. Immunol. 124:429-434(2001).
CC -!- INTERACTION:
CC Q8IX06; Q04864: REL; NbExp=3; IntAct=EBI-10262361, EBI-307352;
CC Q8IX06; P15884: TCF4; NbExp=3; IntAct=EBI-10262361, EBI-533224;
CC Q8IX06; Q8IYF3: TEX11; NbExp=3; IntAct=EBI-10262361, EBI-742397;
CC Q8IX06; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-10262361, EBI-3650647;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11472404}. Nucleus
CC {ECO:0000305|PubMed:11472404}.
CC -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. N-terminally truncated
CC compared to the protein-coding REXO1 gene. Originally thought to encode
CC human GOR47-1, an antigenic epitope identified from the serum of virus
CC infected chimpanzee (see AC P48778), which was apparently also
CC expressed in human and used in ELISA tests to detect hepatitis C virus
CC infection in patients. It turns out that the peptide identified in
CC chimpanzee cannot be produced by human REXO1L1/GOR gene, due to a
CC premature stop codon in the gene (PubMed:11472404) and therefore the
CC basis of the tests remains unclear. However, the same authors provide
CC evidence of the expression of a different N-terminal peptide from the
CC human REXO1L1/GOR gene, the GOR1-125 antigen (PubMed:11472404).
CC {ECO:0000305|PubMed:11472404}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN77012.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AC093331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF495523; AAN77012.1; ALT_SEQ; mRNA.
DR EMBL; AF023669; AAC98149.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8IX06; -.
DR SMR; Q8IX06; -.
DR IntAct; Q8IX06; 5.
DR iPTMnet; Q8IX06; -.
DR PhosphoSitePlus; Q8IX06; -.
DR BioMuta; HGNC:24660; -.
DR DMDM; 205831276; -.
DR MassIVE; Q8IX06; -.
DR MaxQB; Q8IX06; -.
DR PaxDb; Q8IX06; -.
DR PeptideAtlas; Q8IX06; -.
DR PRIDE; Q8IX06; -.
DR DNASU; 254958; -.
DR GeneCards; REXO1L1P; -.
DR HGNC; HGNC:24660; REXO1L1P.
DR neXtProt; NX_Q8IX06; -.
DR InParanoid; Q8IX06; -.
DR PhylomeDB; Q8IX06; -.
DR TreeFam; TF331871; -.
DR PathwayCommons; Q8IX06; -.
DR SignaLink; Q8IX06; -.
DR Pharos; Q8IX06; Tdark.
DR PRO; PR:Q8IX06; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8IX06; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR031736; EloA-BP1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF15870; EloA-BP1; 2.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 5: Uncertain;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1..675
FT /note="Putative exonuclease GOR"
FT /id="PRO_0000120938"
FT REGION 66..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..483
FT /note="GOR1-125 epitope"
FT CONFLICT 272
FT /note="A -> P (in Ref. 2; AAN77012)"
FT /evidence="ECO:0000305"
FT CONFLICT 635
FT /note="D -> N (in Ref. 2; AAN77012)"
FT /evidence="ECO:0000305"
FT CONFLICT 644
FT /note="S -> N (in Ref. 2; AAN77012)"
FT /evidence="ECO:0000305"
FT CONFLICT 667
FT /note="A -> V (in Ref. 2; AAN77012)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 675 AA; 73855 MW; 8397A52718FF6FCB CRC64;
MLRATAPCWF PPGYPEAKKV AEEAALEASR HLGGEQSQAG APEGSKMLRA TAPCWFRPGY
PEAKKVAKEA APEASRHLGA EQSPAGAPEG SKMLRATAPC WFPPGYPEAK KVAEEAALEA
PEFPLPSHQP AQSFGLWVPQ MHKQASAFVD IQAEPQNRGP AVPPAWPKMV TESCYFPAQR
GSACRLPAAP RLTERPSGVR ISAPRKRKTI AHSSSPCLVT GYTDAKRTRV ASSSQRSRGS
KVGRQPGKTR NRSGMACKTT ATTSSKRIVR RASLPSLSLK KPIILRSSGC QVPTVLRRGY
LQLFTEECLK FCASKQEAEE KALNEEKVAY DCSPNKNRYL NVVLNTLKRL KGLTPSSMPG
LSRAALYSRL QEFLLTQDQL KENGYPFPHP ERPGGAVLFT GQGKGPGDSS CRVCCRCGTE
YLVSSSGRCV RDQLCYYHWG RVRSSQVAGG RVSQYTCCAA APGSVGCQVA KQHVRDGRKE
SLDGFVETFK KELSRDAYPG IYALDCEMCY TTHGLELTRV TVVDADMRVV YDTFVKPDNE
IVDYNTRFSG VTEADVAKTS ITLPQVQAIL LSFFSAQTIL IGHSLESDLL ALKLIHSTVV
DTAVLFPHYL GFPYKRSLRN LAADYLAQII QDSQDGHNSS EDASACLQLV MWKVRQRAQI
QPRHRSASPA ALACP
