ID   GOR_PANTR               Reviewed;         690 AA.
AC   P48778; Q28909;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 3.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Exonuclease GOR;
DE            EC=3.1.-.-;
DE   AltName: Full=Antigen GOR;
DE   AltName: Full=RNA exonuclease 1 homolog-like;
GN   Name=REXO1L1; Synonyms=GOR;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-690.
RX   PubMed=1723001; DOI=10.3109/08916939109001900;
RA   Mishiro S., Takeda K., Hoshi Y., Yoshikawa A., Gotanda T., Itoh Y.;
RT   "An autoantibody cross-reactive to hepatitis C virus core and a host
RT   nuclear antigen.";
RL   Autoimmunity 10:269-273(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 598-652.
RX   PubMed=1701012; DOI=10.1016/0140-6736(90)93101-t;
RA   Mishiro S., Hoshi Y., Takeda K., Yoshikawa A., Gotanda T., Takahashi K.,
RA   Akahane Y., Yoshizawa H., Okamoto H., Tsuda F., Peterson D.A., Muchmore E.;
RT   "Non-A, non-B hepatitis specific antibodies directed at host-derived
RT   epitope: implication for an autoimmune process.";
RL   Lancet 336:1400-1403(1990).
RN   [4]
RP   ERRATUM OF PUBMED:1701012.
RA   Mishiro S., Hoshi Y., Takeda K., Yoshikawa A., Gotanda T., Takahashi K.,
RA   Akahane Y., Yoshizawa H., Okamoto H., Tsuda F., Peterson D.A., Muchmore E.;
RL   Lancet 337:252-252(1990).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: May encode GOR14-1, a host antigenic epitope
CC       specifically expressed in response to non-A non-B hepatitis virus
CC       infection.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB21194.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAB21194.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC       Sequence=BAA00906.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D10017; BAA00906.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; S78897; AAB21194.1; ALT_SEQ; mRNA.
DR   PIR; A37238; A37238.
DR   AlphaFoldDB; P48778; -.
DR   SMR; P48778; -.
DR   InParanoid; P48778; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR031736; EloA-BP1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF15870; EloA-BP1; 2.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..690
FT                   /note="Exonuclease GOR"
FT                   /id="PRO_0000120939"
FT   REGION          136..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          612..626
FT                   /note="GOR14-1 epitope"
FT   COMPBIAS        599..613
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..655
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..680
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  75361 MW;  51831AC610F1D218 CRC64;
     MLRATAPCWF PPGYPEAKKV AEEAALEAPE FPLPSHQPAQ SFGLPVPQMH NQASAFVDIQ
     AEPQNRGPAV HPAWPKMVTE ACYFPAQRGS ACCLPAAPRL TERPSGVRIS APRKRKTIAQ
     SSSPCLVTGC TDAKRTRVAS SSQRSSGSKV GRQPGKTRNR SGMACKTTTT ISSKRIVRRP
     SLPSLKKPII LRRSGCQVPT VLRRGYLQLF TEECLKFCAS KQEAEEKALN EEKVAYDCSP
     NKNRYLNVVL NTLKRLKGLT PSSMPGLSRA ALYSRLQEFL LSQDQLKENG YPFPHPERPG
     GAVLFTGQGK GPGDSSCRVC CRCGTEYLVS SSGRCVRDQL CYYHWGRVRS SQVAGGRVSQ
     YTCCAAAPGS VGCQVAKQHV RDGRKDSLDG FVETFKKELS RDAYPGIYAL DCEMCYTTHG
     LELTRVTVVD ADMRVVYDTF VKPDNEIVDY NTRFSGVTEA DVAKTSITLP QVQAILLSFF
     SAQTILIGHS LESDLLALKL IHSTVLDTAV LFPHYLGFPY KRSLRNLAAD YLGQIIQDSQ
     DGHNSSEDAN ACLQLVMWKV RQRAQIQPRH RSASPAALAC PWPQAPSTTA ISPESSPCPP
     RRKAKETGAV DGRRGQKAKS NPNRPLPVPR NPCRGPSGLS PSLCPSQTSV LPLIASRSTE
     PPLPVPRVPA APPRACPHPS AHPRPLSLHH