GOSR1_BOVIN
ID GOSR1_BOVIN Reviewed; 250 AA.
AC Q2TBU3;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Golgi SNAP receptor complex member 1;
DE AltName: Full=28 kDa Golgi SNARE protein;
DE AltName: Full=28 kDa cis-Golgi SNARE p28;
GN Name=GOSR1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SUBCELLULAR LOCATION, AND INDUCTION BY MONOCROTALINE.
RX PubMed=17337506; DOI=10.1152/ajplung.00463.2006;
RA Sehgal P.B., Mukhopadhyay S., Xu F., Patel K., Shah M.;
RT "Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced
RT pulmonary hypertension.";
RL Am. J. Physiol. 292:L1526-L1542(2007).
CC -!- FUNCTION: Involved in transport from the ER to the Golgi apparatus as
CC well as in intra-Golgi transport. It belongs to a super-family of
CC proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive
CC factor) attachment protein receptor. May play a protective role against
CC hydrogen peroxide induced cytotoxicity under glutathione depleted
CC conditions in neuronal cells by regulating the intracellular ROS levels
CC via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14).
CC Participates in docking and fusion stage of ER to cis-Golgi transport.
CC Plays an important physiological role in VLDL-transport vesicle-Golgi
CC fusion and thus in VLDL delivery to the hepatic cis-Golgi (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of several multiprotein Golgi SNARE complexes.
CC Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE
CC complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2,
CC SEC22B and BET1, and in complex with STX5 and COG3. Interacts with
CC GABARAPL2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:17337506}; Single-pass type IV membrane protein
CC {ECO:0000269|PubMed:17337506}. Note=Localizes throughout the Golgi
CC apparatus, with lowest levels in the trans-Golgi network (By
CC similarity). Enriched on vesicular components at the terminal rims of
CC the Golgi. {ECO:0000250}.
CC -!- INDUCTION: By monocrotaline. {ECO:0000269|PubMed:17337506}.
CC -!- SIMILARITY: Belongs to the GOSR1 family. {ECO:0000305}.
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DR EMBL; BC109657; AAI09658.1; -; mRNA.
DR RefSeq; NP_001033614.1; NM_001038525.1.
DR AlphaFoldDB; Q2TBU3; -.
DR SMR; Q2TBU3; -.
DR STRING; 9913.ENSBTAP00000006525; -.
DR SwissPalm; Q2TBU3; -.
DR PaxDb; Q2TBU3; -.
DR Ensembl; ENSBTAT00000006525; ENSBTAP00000006525; ENSBTAG00000004961.
DR GeneID; 511030; -.
DR KEGG; bta:511030; -.
DR CTD; 9527; -.
DR VEuPathDB; HostDB:ENSBTAG00000004961; -.
DR VGNC; VGNC:29500; GOSR1.
DR eggNOG; KOG3208; Eukaryota.
DR GeneTree; ENSGT00390000008688; -.
DR InParanoid; Q2TBU3; -.
DR OMA; QAYAVND; -.
DR OrthoDB; 1319902at2759; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000004961; Expressed in oocyte and 107 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005797; C:Golgi medial cisterna; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR023601; Golgi_SNAP_su1.
DR PANTHER; PTHR21094; PTHR21094; 1.
DR PIRSF; PIRSF027109; Golgi_SNARE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; ER-Golgi transport; Golgi apparatus; Membrane;
KW Phosphoprotein; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95249"
FT CHAIN 2..250
FT /note="Golgi SNAP receptor complex member 1"
FT /id="PRO_0000239656"
FT TOPO_DOM 2..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT REGION 39..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..30
FT /evidence="ECO:0000255"
FT COILED 70..93
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O95249"
FT MOD_RES 141
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95249"
SQ SEQUENCE 250 AA; 28542 MW; BD0D96332E0CCE1A CRC64;
MAAGTSNYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS SARDGRRDRY SSDTTPLLNG
SSQDRMFETM AIEIEQLLAR LTGINDKMAE YTSSAGVPSL NAALMHTLQR HRDILQDYTH
EFHKTKANFV AIRERENLMG SVRKDIESYK SGSGVNNRRT ELFLKEHDHL RNSDRLIEET
ISIAMATKEN MTSQRGMLKS IQSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGVC
TILLLLYAFH
