GOSR1_CAEEL
ID GOSR1_CAEEL Reviewed; 234 AA.
AC Q95ZW1;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Golgi SNAP receptor complex member 1;
DE AltName: Full=28 kDa Golgi SNARE protein;
DE Short=GOS-28;
GN Name=gos-28; Synonyms=gosr-1, gs28; ORFNames=F08F8.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=19624756; DOI=10.1111/j.1365-2443.2009.01325.x;
RA Maekawa M., Inoue T., Kobuna H., Nishimura T., Gengyo-Ando K., Mitani S.,
RA Arai H.;
RT "Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis
RT elegans.";
RL Genes Cells 14:1003-1013(2009).
CC -!- FUNCTION: Involved in transport from the ER to the Golgi apparatus as
CC well as in intra-Golgi transport. It belongs to a super-family of
CC proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive
CC factor) attachment protein receptor. Cooperates with ykt-6 for proper
CC expression of Golgi-resident proteins. Required along with ykt-6 for
CC normal embryonic development, seam cell division or differentiation,
CC and ray formation. {ECO:0000269|PubMed:19624756}.
CC -!- SUBUNIT: Component of several multiprotein Golgi SNARE complexes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type IV membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in two-fold stage embryos in the lateral
CC epithelial cells (seam cells) and continues throughout all larval
CC stages. In adults, expression becomes faint in seam cells and strong in
CC intestinal cells. Also weakly expressed in epithelial cells of the
CC vulva. Overall, expression appears to be restricted to certain types of
CC epithelial cells and changes with developmental stages.
CC {ECO:0000269|PubMed:19624756}.
CC -!- DISRUPTION PHENOTYPE: Reduction in brood size at adulthood. Abnormal
CC tail structure, and loss of the T-cell derived rays, R7-R9, of the
CC male-specific sensory rays, but ray sensory function remains intact.
CC Combined with ykt-6 knock-down causes reduced seam cell leading to loss
CC of ray phenotype. At cellular level, reduced expression of Golgi-
CC resident proteins like mannosidase II, and more so in combination with
CC ykt-6 knock-down. {ECO:0000269|PubMed:19624756}.
CC -!- SIMILARITY: Belongs to the GOSR1 family. {ECO:0000305}.
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DR EMBL; FO081093; CCD69065.1; -; Genomic_DNA.
DR RefSeq; NP_498621.1; NM_066220.4.
DR AlphaFoldDB; Q95ZW1; -.
DR SMR; Q95ZW1; -.
DR BioGRID; 41253; 1.
DR STRING; 6239.F08F8.8; -.
DR EPD; Q95ZW1; -.
DR PaxDb; Q95ZW1; -.
DR PeptideAtlas; Q95ZW1; -.
DR EnsemblMetazoa; F08F8.8.1; F08F8.8.1; WBGene00017273.
DR GeneID; 176044; -.
DR KEGG; cel:CELE_F08F8.8; -.
DR UCSC; F08F8.8; c. elegans.
DR CTD; 176044; -.
DR WormBase; F08F8.8; CE27935; WBGene00017273; gos-28.
DR eggNOG; KOG3208; Eukaryota.
DR GeneTree; ENSGT00390000008688; -.
DR HOGENOM; CLU_078034_0_1_1; -.
DR InParanoid; Q95ZW1; -.
DR OMA; RDYGSEY; -.
DR OrthoDB; 1319902at2759; -.
DR PhylomeDB; Q95ZW1; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR PRO; PR:Q95ZW1; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00017273; Expressed in embryo and 3 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005797; C:Golgi medial cisterna; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR023601; Golgi_SNAP_su1.
DR PANTHER; PTHR21094; PTHR21094; 1.
DR PIRSF; PIRSF027109; Golgi_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; ER-Golgi transport; Golgi apparatus; Membrane;
KW Protein transport; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..234
FT /note="Golgi SNAP receptor complex member 1"
FT /id="PRO_0000415671"
FT TOPO_DOM 1..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT COILED 54..121
FT /evidence="ECO:0000255"
SQ SEQUENCE 234 AA; 26776 MW; A3176FE9FF31EA53 CRC64;
MSETWEALRK KARSTENSID VKLVSLNKLT ASSHGGFDID EKTVSSRQTS FKTVTTEIEG
LIEQLTNIND DMNDVAGAQS SASWANNPAI QHTLRRHREI LRDYGSEYRR ARDNVDQVLQ
RELLLSSSNE NRNNPILNNR ARGYDMYLKE NDHINACDRL LDEQLEMAMS TKENMARQGI
NLRGISTRLH HISKKYPAIN NLMQKIKTKK QKNTLILAAV ISSCLIFTIF WIIN
