GOSR1_DROME
ID GOSR1_DROME Reviewed; 232 AA.
AC Q9VE50; Q8SWZ4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Golgi SNAP receptor complex member 1;
DE AltName: Full=Probable 28 kDa Golgi SNARE protein;
GN Name=Gos28; ORFNames=CG7700;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Involved in transport from the ER to the Golgi apparatus as
CC well as in intra-Golgi transport. It belongs to a super-family of
CC proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive
CC factor) attachment protein receptor (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of several multiprotein Golgi SNARE complexes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type IV membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GOSR1 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55579.1; -; Genomic_DNA.
DR EMBL; AY094935; AAM11288.1; -; mRNA.
DR RefSeq; NP_650739.2; NM_142482.4.
DR AlphaFoldDB; Q9VE50; -.
DR SMR; Q9VE50; -.
DR BioGRID; 73975; 22.
DR IntAct; Q9VE50; 9.
DR STRING; 7227.FBpp0083076; -.
DR PaxDb; Q9VE50; -.
DR PRIDE; Q9VE50; -.
DR DNASU; 248102; -.
DR EnsemblMetazoa; FBtr0083661; FBpp0083076; FBgn0044871.
DR GeneID; 248102; -.
DR KEGG; dme:Dmel_CG7700; -.
DR UCSC; CG7700-RA; d. melanogaster.
DR CTD; 248102; -.
DR FlyBase; FBgn0044871; Gos28.
DR VEuPathDB; VectorBase:FBgn0044871; -.
DR eggNOG; KOG3208; Eukaryota.
DR GeneTree; ENSGT00390000008688; -.
DR HOGENOM; CLU_078034_0_1_1; -.
DR InParanoid; Q9VE50; -.
DR OMA; RDYGSEY; -.
DR OrthoDB; 1319902at2759; -.
DR PhylomeDB; Q9VE50; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR BioGRID-ORCS; 248102; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Gos28; fly.
DR GenomeRNAi; 248102; -.
DR PRO; PR:Q9VE50; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0044871; Expressed in saliva-secreting gland and 24 other tissues.
DR ExpressionAtlas; Q9VE50; baseline and differential.
DR Genevisible; Q9VE50; DM.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005797; C:Golgi medial cisterna; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:FlyBase.
DR GO; GO:0031201; C:SNARE complex; ISS:FlyBase.
DR GO; GO:0005484; F:SNAP receptor activity; IMP:FlyBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0048193; P:Golgi vesicle transport; ISS:FlyBase.
DR GO; GO:0048219; P:inter-Golgi cisterna vesicle-mediated transport; IMP:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; ISS:FlyBase.
DR InterPro; IPR023601; Golgi_SNAP_su1.
DR PANTHER; PTHR21094; PTHR21094; 1.
DR PIRSF; PIRSF027109; Golgi_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; ER-Golgi transport; Golgi apparatus; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..232
FT /note="Golgi SNAP receptor complex member 1"
FT /id="PRO_0000212546"
FT TOPO_DOM 1..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT COILED 6..23
FT /evidence="ECO:0000255"
FT COILED 52..80
FT /evidence="ECO:0000255"
FT CONFLICT 34
FT /note="S -> C (in Ref. 3; AAM11288)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 232 AA; 25562 MW; 45C657EA56C33125 CRC64;
MGGSSYDVLR KQARSLENEI DLKLVAFSKI GAGSGGGGSG GLGGVDTSPL LGEHVFDSLS
EEIEQMLEKL SSLNESMSDL PASGAAAMHT LQRHREILQG YRQEFNKICA NHTMRIEREE
LLRGSGLATS SGSPSISGLN RREMYLKESG HLNSASHLVN DQINIAIETR DHLHAQRQAF
KRLQTRFNDI SNRFPLISSL IQRINIKKRR DSLILGAVIG FCVILLLLYA FN
