GOSR2_CAEEL
ID GOSR2_CAEEL Reviewed; 213 AA.
AC P41941;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Golgi SNAP receptor complex member 2 homolog memb-1 {ECO:0000305};
GN Name=memb-1 {ECO:0000312|WormBase:B0272.2};
GN Synonyms=gosr-2.1 {ECO:0000312|WormBase:B0272.2}; ORFNames=B0272.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Involved in transport of proteins from the cis/medial-Golgi
CC to the trans-Golgi network. {ECO:0000250|UniProtKB:O35165}.
CC -!- SUBUNIT: Part of a unique SNARE complex.
CC {ECO:0000250|UniProtKB:O35165}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250|UniProtKB:O35165}; Single-pass type IV membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O35165}.
CC Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35165}.
CC Note=Concentrated most in the intermediate compartment/cis-Golgi
CC network and the cis-Golgi cisternae 1 and 2. Greatly reduced in
CC concentration at the trans end of the Golgi apparatus.
CC {ECO:0000250|UniProtKB:O35165}.
CC -!- SIMILARITY: Belongs to the GOSR2 family. {ECO:0000305}.
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DR EMBL; Z46240; CAA86311.1; -; Genomic_DNA.
DR PIR; T18684; T18684.
DR RefSeq; NP_509586.1; NM_077185.1.
DR AlphaFoldDB; P41941; -.
DR SMR; P41941; -.
DR BioGRID; 46757; 5.
DR DIP; DIP-26036N; -.
DR IntAct; P41941; 4.
DR STRING; 6239.B0272.2; -.
DR EPD; P41941; -.
DR PaxDb; P41941; -.
DR PeptideAtlas; P41941; -.
DR EnsemblMetazoa; B0272.2.1; B0272.2.1; WBGene00007128.
DR GeneID; 181891; -.
DR KEGG; cel:CELE_B0272.2; -.
DR CTD; 181891; -.
DR WormBase; B0272.2; CE00851; WBGene00007128; memb-1.
DR eggNOG; KOG3251; Eukaryota.
DR GeneTree; ENSGT00940000164674; -.
DR HOGENOM; CLU_083740_0_0_1; -.
DR InParanoid; P41941; -.
DR OMA; RMRVDQL; -.
DR OrthoDB; 1139640at2759; -.
DR PhylomeDB; P41941; -.
DR Reactome; R-CEL-204005; COPII-mediated vesicle transport.
DR Reactome; R-CEL-5694530; Cargo concentration in the ER.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR PRO; PR:P41941; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00007128; Expressed in embryo and 3 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR027027; GOSR2/Membrin/Bos1.
DR PIRSF; PIRSF028865; Membrin-2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..213
FT /note="Golgi SNAP receptor complex member 2 homolog memb-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000212552"
FT TOPO_DOM 1..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..213
FT /note="Vesicular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 213 AA; 24650 MW; E8C862EF68D358D4 CRC64;
MEALYQSTNF LLQKVQHDLG RLEGTQNEQD AQVVVQCIYG DVITLKENCQ TLDNYVSREP
PARRQAARMR VDQLRADVHR VDMAVSAVHT RMTQRWRAAT ERDELLRTRY RPNDTALSIG
DHELLLNDRL QSSHTHLDDL ISQGSAVLEN LKSQHLNLRG VGRKMHEIGQ ALGLSNSTLQ
VIDRRVREDW ILFVIGCIVC CIFMYAFYRF WRG
