GOT1A_HUMAN
ID GOT1A_HUMAN Reviewed; 132 AA.
AC Q6ZVE7;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Vesicle transport protein GOT1A;
DE AltName: Full=Golgi transport 1 homolog A;
DE AltName: Full=hGOT1b;
GN Name=GOLT1A {ECO:0000312|HGNC:HGNC:24766}; Synonyms=GOT1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:BAC85915.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum {ECO:0000312|EMBL:BAC85915.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3] {ECO:0000312|EMBL:AAH58832.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP PUTATIVE FUNCTION.
RX PubMed=10406798; DOI=10.1093/emboj/18.14.3934;
RA Conchon S., Cao X., Barlowe C., Pelham H.R.;
RT "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi
RT complex.";
RL EMBO J. 18:3934-3946(1999).
CC -!- FUNCTION: May be involved in fusion of ER-derived transport vesicles
CC with the Golgi complex. {ECO:0000269|PubMed:10406798}.
CC -!- INTERACTION:
CC Q6ZVE7; O95870: ABHD16A; NbExp=3; IntAct=EBI-17231387, EBI-348517;
CC Q6ZVE7; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-17231387, EBI-2803601;
CC Q6ZVE7; Q13520: AQP6; NbExp=3; IntAct=EBI-17231387, EBI-13059134;
CC Q6ZVE7; P07357: C8A; NbExp=3; IntAct=EBI-17231387, EBI-9021639;
CC Q6ZVE7; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-17231387, EBI-9083477;
CC Q6ZVE7; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-17231387, EBI-11959453;
CC Q6ZVE7; Q5RI15: COX20; NbExp=3; IntAct=EBI-17231387, EBI-2834035;
CC Q6ZVE7; Q92523: CPT1B; NbExp=3; IntAct=EBI-17231387, EBI-10278486;
CC Q6ZVE7; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-17231387, EBI-12142299;
CC Q6ZVE7; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-17231387, EBI-13345167;
CC Q6ZVE7; P02724: GYPA; NbExp=3; IntAct=EBI-17231387, EBI-702665;
CC Q6ZVE7; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-17231387, EBI-1052304;
CC Q6ZVE7; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-17231387, EBI-12866138;
CC Q6ZVE7; Q15800: MSMO1; NbExp=3; IntAct=EBI-17231387, EBI-949102;
CC Q6ZVE7; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-17231387, EBI-2863634;
CC Q6ZVE7; O95167: NDUFA3; NbExp=3; IntAct=EBI-17231387, EBI-1246131;
CC Q6ZVE7; Q8IXM6: NRM; NbExp=3; IntAct=EBI-17231387, EBI-10262547;
CC Q6ZVE7; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-17231387, EBI-6916492;
CC Q6ZVE7; Q9Y342: PLLP; NbExp=3; IntAct=EBI-17231387, EBI-3919291;
CC Q6ZVE7; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-17231387, EBI-13044680;
CC Q6ZVE7; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-17231387, EBI-8644112;
CC Q6ZVE7; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-17231387, EBI-17295964;
CC Q6ZVE7; Q9NZ01: TECR; NbExp=3; IntAct=EBI-17231387, EBI-2877718;
CC Q6ZVE7; O14925: TIMM23; NbExp=3; IntAct=EBI-17231387, EBI-1047996;
CC Q6ZVE7; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-17231387, EBI-10315004;
CC Q6ZVE7; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-17231387, EBI-988826;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GOT1 family. {ECO:0000255}.
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DR EMBL; AK124645; BAC85915.1; -; mRNA.
DR EMBL; AL592114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC058832; AAH58832.1; -; mRNA.
DR CCDS; CCDS1443.1; -.
DR RefSeq; NP_940849.1; NM_198447.1.
DR AlphaFoldDB; Q6ZVE7; -.
DR BioGRID; 126087; 33.
DR IntAct; Q6ZVE7; 26.
DR STRING; 9606.ENSP00000308535; -.
DR BioMuta; GOLT1A; -.
DR DMDM; 74749697; -.
DR MassIVE; Q6ZVE7; -.
DR PaxDb; Q6ZVE7; -.
DR PeptideAtlas; Q6ZVE7; -.
DR PRIDE; Q6ZVE7; -.
DR ProteomicsDB; 68412; -.
DR Antibodypedia; 53844; 89 antibodies from 17 providers.
DR DNASU; 127845; -.
DR Ensembl; ENST00000308302.4; ENSP00000308535.3; ENSG00000174567.8.
DR GeneID; 127845; -.
DR KEGG; hsa:127845; -.
DR MANE-Select; ENST00000308302.4; ENSP00000308535.3; NM_198447.2; NP_940849.1.
DR UCSC; uc001has.1; human.
DR CTD; 127845; -.
DR DisGeNET; 127845; -.
DR GeneCards; GOLT1A; -.
DR HGNC; HGNC:24766; GOLT1A.
DR HPA; ENSG00000174567; Tissue enriched (liver).
DR neXtProt; NX_Q6ZVE7; -.
DR OpenTargets; ENSG00000174567; -.
DR PharmGKB; PA134874119; -.
DR VEuPathDB; HostDB:ENSG00000174567; -.
DR eggNOG; KOG1743; Eukaryota.
DR GeneTree; ENSGT00390000014507; -.
DR HOGENOM; CLU_124519_2_0_1; -.
DR InParanoid; Q6ZVE7; -.
DR OMA; KTFWFFF; -.
DR OrthoDB; 1534843at2759; -.
DR PhylomeDB; Q6ZVE7; -.
DR TreeFam; TF300267; -.
DR PathwayCommons; Q6ZVE7; -.
DR SignaLink; Q6ZVE7; -.
DR BioGRID-ORCS; 127845; 8 hits in 1072 CRISPR screens.
DR ChiTaRS; GOLT1A; human.
DR GenomeRNAi; 127845; -.
DR Pharos; Q6ZVE7; Tdark.
DR PRO; PR:Q6ZVE7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6ZVE7; protein.
DR Bgee; ENSG00000174567; Expressed in right lobe of liver and 101 other tissues.
DR Genevisible; Q6ZVE7; HS.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0000137; C:Golgi cis cisterna; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IDA:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR InterPro; IPR045176; Got1.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR PANTHER; PTHR21493; PTHR21493; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..132
FT /note="Vesicle transport protein GOT1A"
FT /id="PRO_0000237607"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..100
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 132 AA; 14887 MW; 74FA90D30D372FC2 CRC64;
MISITEWQKI GVGITGFGIF FILFGTLLYF DSVLLAFGNL LFLTGLSLII GLRKTFWFFF
QRHKLKGTSF LLGGVVIVLL RWPLLGMFLE TYGFFSLFKG FFPVAFGFLG NVCNIPFLGA
LFRRLQGTSS MV
