GOT1A_MOUSE
ID GOT1A_MOUSE Reviewed; 133 AA.
AC Q9DCQ3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Vesicle transport protein GOT1A;
DE AltName: Full=Golgi transport 1 homolog A;
GN Name=Golt1a {ECO:0000312|MGI:MGI:1915588};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAW34128.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAW34128.1};
RC TISSUE=Placenta {ECO:0000312|EMBL:AAW34128.1};
RA Xie H., Bonaldo M.F., Soares M.B.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAB22205.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB22205.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAE24665.1}, and
RC Kidney {ECO:0000312|EMBL:BAB22205.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAH24448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH24448.1};
RC TISSUE=Kidney {ECO:0000312|EMBL:AAH24448.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in fusion of ER-derived transport vesicles
CC with the Golgi complex. {ECO:0000250|UniProtKB:Q9Y3E0}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GOT1 family. {ECO:0000255}.
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DR EMBL; AY707855; AAW34128.1; -; mRNA.
DR EMBL; AY707856; AAW34129.1; -; mRNA.
DR EMBL; AK002581; BAB22205.1; -; mRNA.
DR EMBL; AK141378; BAE24665.1; -; mRNA.
DR EMBL; BC024448; AAH24448.1; -; mRNA.
DR CCDS; CCDS35709.1; -.
DR RefSeq; NP_080956.1; NM_026680.4.
DR AlphaFoldDB; Q9DCQ3; -.
DR STRING; 10090.ENSMUSP00000138922; -.
DR MaxQB; Q9DCQ3; -.
DR PaxDb; Q9DCQ3; -.
DR PRIDE; Q9DCQ3; -.
DR DNASU; 68338; -.
DR Ensembl; ENSMUST00000094557; ENSMUSP00000092136; ENSMUSG00000103421.
DR Ensembl; ENSMUST00000183489; ENSMUSP00000139189; ENSMUSG00000098306.
DR GeneID; 68338; -.
DR KEGG; mmu:68338; -.
DR UCSC; uc007cqa.1; mouse.
DR CTD; 127845; -.
DR MGI; MGI:1915588; Golt1a.
DR VEuPathDB; HostDB:ENSMUSG00000098306; -.
DR VEuPathDB; HostDB:ENSMUSG00000103421; -.
DR eggNOG; KOG1743; Eukaryota.
DR GeneTree; ENSGT00390000014507; -.
DR HOGENOM; CLU_124519_2_0_1; -.
DR InParanoid; Q9DCQ3; -.
DR OMA; KTFWFFF; -.
DR OrthoDB; 1534843at2759; -.
DR PhylomeDB; Q9DCQ3; -.
DR TreeFam; TF300267; -.
DR BioGRID-ORCS; 68338; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q9DCQ3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9DCQ3; protein.
DR Bgee; ENSMUSG00000098306; Expressed in jejunum and 16 other tissues.
DR ExpressionAtlas; Q9DCQ3; baseline and differential.
DR Genevisible; Q9DCQ3; MM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0000137; C:Golgi cis cisterna; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR GO; GO:0005802; C:trans-Golgi network; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR InterPro; IPR045176; Got1.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR PANTHER; PTHR21493; PTHR21493; 1.
DR Pfam; PF04178; Got1; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..133
FT /note="Vesicle transport protein GOT1A"
FT /id="PRO_0000237608"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..92
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 133 AA; 14800 MW; 32ACEC0D779C40D2 CRC64;
MISITEWQKI GVGITGFGVF FILFGILLYF DSVLLAFGNL LFLTGLSLII GLRRTFAFFF
QRHKLKGTSF FLGGVAIVLL RWPLLGMLLE AYGFISLFKG FFPVVFGFLG SAFNIPFLST
LFQKLQGSSS SMV
