GOT1B_MOUSE
ID GOT1B_MOUSE Reviewed; 138 AA.
AC Q9CR60;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Vesicle transport protein GOT1B;
DE AltName: Full=Golgi transport 1 homolog B;
GN Name=Golt1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic germ cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in fusion of ER-derived transport vesicles
CC with the Golgi complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GOT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31257.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK009991; BAB26630.1; -; mRNA.
DR EMBL; AK018531; BAB31257.2; ALT_INIT; mRNA.
DR EMBL; BC085246; AAH85246.1; -; mRNA.
DR CCDS; CCDS20682.1; -.
DR RefSeq; NP_080148.1; NM_025872.4.
DR AlphaFoldDB; Q9CR60; -.
DR BioGRID; 211840; 3.
DR STRING; 10090.ENSMUSP00000032372; -.
DR iPTMnet; Q9CR60; -.
DR PhosphoSitePlus; Q9CR60; -.
DR EPD; Q9CR60; -.
DR MaxQB; Q9CR60; -.
DR PaxDb; Q9CR60; -.
DR PeptideAtlas; Q9CR60; -.
DR PRIDE; Q9CR60; -.
DR ProteomicsDB; 271255; -.
DR Antibodypedia; 67178; 60 antibodies from 17 providers.
DR DNASU; 66964; -.
DR Ensembl; ENSMUST00000032372; ENSMUSP00000032372; ENSMUSG00000030245.
DR GeneID; 66964; -.
DR KEGG; mmu:66964; -.
DR UCSC; uc009epg.1; mouse.
DR CTD; 51026; -.
DR MGI; MGI:1914214; Golt1b.
DR VEuPathDB; HostDB:ENSMUSG00000030245; -.
DR eggNOG; KOG1743; Eukaryota.
DR GeneTree; ENSGT00390000014507; -.
DR HOGENOM; CLU_124519_1_0_1; -.
DR InParanoid; Q9CR60; -.
DR OMA; VLMFFDR; -.
DR OrthoDB; 1534843at2759; -.
DR PhylomeDB; Q9CR60; -.
DR TreeFam; TF300267; -.
DR BioGRID-ORCS; 66964; 18 hits in 72 CRISPR screens.
DR ChiTaRS; Golt1b; mouse.
DR PRO; PR:Q9CR60; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CR60; protein.
DR Bgee; ENSMUSG00000030245; Expressed in undifferentiated genital tubercle and 248 other tissues.
DR Genevisible; Q9CR60; MM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR InterPro; IPR045176; Got1.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR PANTHER; PTHR21493; PTHR21493; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..138
FT /note="Vesicle transport protein GOT1B"
FT /id="PRO_0000218583"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..32
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..109
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3E0"
SQ SEQUENCE 138 AA; 15422 MW; 1BE20294C1C670E5 CRC64;
MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI GLERTFRFFF
QRHKVKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG FFPVVVGFIR RVPVLGSLLN
LPGIRSFVDK VGESNNMV
