GOT1_ARATH
ID GOT1_ARATH Reviewed; 140 AA.
AC Q6NMM1; Q9M9N7;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Vesicle transport protein GOT1 {ECO:0000303|PubMed:25900983};
DE AltName: Full=Golgi transport 1 {ECO:0000303|PubMed:25900983};
GN Name=GOT1 {ECO:0000303|PubMed:25900983};
GN OrderedLocusNames=At3g03180 {ECO:0000312|Araport:AT3G03180};
GN ORFNames=T17B22.13 {ECO:0000312|EMBL:AAF26123.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAS47642.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=25900983; DOI=10.1074/mcp.m115.050286;
RA Heard W., Sklenar J., Tome D.F., Robatzek S., Jones A.M.;
RT "Identification of regulatory and cargo proteins of endosomal and secretory
RT pathways in Arabidopsis thaliana by proteomic dissection.";
RL Mol. Cell. Proteomics 14:1796-1813(2015).
RN [5]
RP LACK OF INTERACTION WITH STL1; STL2; CESA1; CESA3; CESA4; CESA6; CESA7 AND
RP CESA8, AND SUBUNIT.
RX PubMed=27277162; DOI=10.1038/ncomms11656;
RA Zhang Y., Nikolovski N., Sorieul M., Vellosillo T., McFarlane H.E.,
RA Dupree R., Kesten C., Schneider R., Driemeier C., Lathe R., Lampugnani E.,
RA Yu X., Ivakov A., Doblin M.S., Mortimer J.C., Brown S.P., Persson S.,
RA Dupree P.;
RT "Golgi-localized STELLO proteins regulate the assembly and trafficking of
RT cellulose synthase complexes in Arabidopsis.";
RL Nat. Commun. 7:11656-11656(2016).
CC -!- FUNCTION: May be involved in fusion of ER-derived transport vesicles
CC with the Golgi complex. {ECO:0000250|UniProtKB:Q6ZVE7}.
CC -!- SUBUNIT: Homodimer. No interactions with STL1, STL2, CESA1, CESA3,
CC CESA4, CESA6, CESA7 or CESA8. {ECO:0000269|PubMed:27277162}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:25900983}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the GOT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF26123.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC012328; AAF26123.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73910.1; -; Genomic_DNA.
DR EMBL; BT010925; AAR24703.1; -; mRNA.
DR EMBL; BT011636; AAS47642.1; -; mRNA.
DR RefSeq; NP_186968.2; NM_111188.4.
DR AlphaFoldDB; Q6NMM1; -.
DR IntAct; Q6NMM1; 1.
DR STRING; 3702.AT3G03180.1; -.
DR PaxDb; Q6NMM1; -.
DR EnsemblPlants; AT3G03180.1; AT3G03180.1; AT3G03180.
DR GeneID; 821059; -.
DR Gramene; AT3G03180.1; AT3G03180.1; AT3G03180.
DR KEGG; ath:AT3G03180; -.
DR Araport; AT3G03180; -.
DR TAIR; locus:2097745; AT3G03180.
DR eggNOG; KOG1743; Eukaryota.
DR HOGENOM; CLU_124519_1_0_1; -.
DR InParanoid; Q6NMM1; -.
DR OMA; VLTGWPI; -.
DR PhylomeDB; Q6NMM1; -.
DR PRO; PR:Q6NMM1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q6NMM1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR InterPro; IPR045176; Got1.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR PANTHER; PTHR21493; PTHR21493; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..140
FT /note="Vesicle transport protein GOT1"
FT /id="PRO_0000437206"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 140 AA; 15717 MW; 127347883C44B9E2 CRC64;
MASLEMNDLK KIGLGLTGFG VFFTFLGVIF VFDKGLIAMG NILFLAGVTL TIGINPAIQF
FTKRQNFKGT ISFGLGFLLV VFGWPIFGLL LESYGFLVLF SGFWPTLAVF LQRIPLLGWL
LQQPYIRSLL DRYRGRRVPV
