GO_HHV6G
ID GO_HHV6G Reviewed; 651 AA.
AC P30005; P30006;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 29-SEP-2021, entry version 58.
DE RecName: Full=120 kDa Glycoprotein O;
DE Short=gO-120K;
DE AltName: Full=Glycoprotein U47;
DE Contains:
DE RecName: Full=80 kDa Glycoprotein O;
DE Short=gO-80K;
DE Flags: Precursor;
GN Name=U47; Synonyms=RF3/RF4;
OS Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic
OS virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX NCBI_TaxID=10369;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1654455; DOI=10.1128/jvi.65.10.5597-5604.1991;
RA Josephs S.F., Ablashi D.V., Salahuddin S.Z., Jagodzinski L.L.,
RA Wong-Staal F., Gallo R.C.;
RT "Identification of the human herpesvirus 6 glycoprotein H and putative
RT large tegument protein genes.";
RL J. Virol. 65:5597-5604(1991).
RN [2]
RP IDENTIFICATION IN COMPLEX WITH GLYCOPROTEIN L AND GLYCOPROTEIN H,
RP SUBCELLULAR LOCATION (80K GLYCOPROTEIN O), SUBUNIT (80K GLYCOPROTEIN O),
RP GLYCOSYLATION (80K GLYCOPROTEIN O), AND GLYCOSYLATION (120K GLYCOPROTEIN
RP O).
RX PubMed=15078943; DOI=10.1128/jvi.78.9.4609-4616.2004;
RA Mori Y., Akkapaiboon P., Yonemoto S., Koike M., Takemoto M., Sadaoka T.,
RA Sasamoto Y., Konishi S., Uchiyama Y., Yamanishi K.;
RT "Discovery of a second form of tripartite complex containing gH-gL of human
RT herpesvirus 6 and observations on CD46.";
RL J. Virol. 78:4609-4616(2004).
RN [3]
RP PROTEOLYTIC CLEAVAGE (120K GLYCOPROTEIN O), AND SUBCELLULAR LOCATION (80K
RP GLYCOPROTEIN O).
RX PubMed=25694589; DOI=10.1128/jvi.00140-15;
RA Tang H., Mahmoud N.F., Mori Y.;
RT "Maturation of human herpesvirus 6A glycoprotein O requires coexpression of
RT glycoprotein H and glycoprotein L.";
RL J. Virol. 89:5159-5163(2015).
CC -!- SUBUNIT: [80 kDa Glycoprotein O]: Part of a gH-gL-gO complex.
CC {ECO:0000269|PubMed:15078943}.
CC -!- SUBCELLULAR LOCATION: [80 kDa Glycoprotein O]: Virion
CC {ECO:0000269|PubMed:15078943}. Host cell membrane
CC {ECO:0000269|PubMed:25694589}. Note=Expressed on the host cell surface
CC as a part of the gH-gL-gO complex. {ECO:0000269|PubMed:25694589}.
CC -!- PTM: [120 kDa Glycoprotein O]: A shorter mature protein, gO-80K, is
CC produced probably by proteolytic cleavage.
CC {ECO:0000269|PubMed:25694589}.
CC -!- PTM: [120 kDa Glycoprotein O]: Modified with high mannose-
CC oligosaccharides. {ECO:0000269|PubMed:15078943}.
CC -!- PTM: [80 kDa Glycoprotein O]: N-glycosylated with complex glycans.
CC {ECO:0000269|PubMed:15078943}.
CC -!- SIMILARITY: Belongs to the herpesviridae U47 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-34 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB19780.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAB19781.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; S57509; AAB19780.1; ALT_FRAME; Genomic_DNA.
DR EMBL; S57509; AAB19781.1; ALT_FRAME; Genomic_DNA.
DR PIR; B40511; B40511.
DR PIR; PQ0856; PQ0856.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008645; Roseolovirus_U47.
DR Pfam; PF05467; Herpes_U47; 2.
PE 1: Evidence at protein level;
KW Glycoprotein; Host cell membrane; Host membrane; Membrane; Signal; Virion.
FT SIGNAL 1..56
FT /evidence="ECO:0000255"
FT CHAIN 57..651
FT /note="120 kDa Glycoprotein O"
FT /id="PRO_0000038315"
FT CHAIN 57..?
FT /note="80 kDa Glycoprotein O"
FT /id="PRO_0000445357"
FT REGION 275..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 208
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 395
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 502
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 520
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 603
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 620
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 631
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 651 AA; 73273 MW; 7CA6D9ACC66E2477 CRC64;
MHLEVIVQSY KKSKYYFSHT FYLYKFIVVN SPDMLHISQL GLFLGLFAIV MHSANLIKYT
SDPLEAFKTV NRHNWSDEQR EHFYDLRNLY TSFCQTNLSL DCFTQILTNV FSWDIRDSQC
KSAVNLSPLQ NLPRTETKIV LSSTAANKSI IASSFSLFYL LFATLSTYTA DPPCVELLPF
KILGAQLFDI KLTEESLRMA MSKFSNSNLT RSLTSFTSEI FFNYTSFVYF LLYNTTSCVP
SNDQYFKQSP KPINVTTSFG RTIVNFDSIL TTTPSSTSAS LTSPHIPSTN IPTPEPPPVT
KNSTKLHTDT IKVTPNTPTI TTQTTESIKK IVKRSDFPRP MYTPTDIPTL TIRLNATIKT
EQNTENPKSP PKPTNFENTT IRIPKTFESA TVTTNATQKI ESTTFTTIGI KEINGNTYSS
PKNSIYLKSK SQQSTTKFTD AEHTTPILKF TTWQNTARTY MSHNTEVQNM TDRFQRTTLK
SSNELPTIQT LSVTPKQKLP SNVTAKTEVH ITNNALPSSN SSYSITEVTK EVKHTRMSAS
THEEINHTEI AQITPILNAH TSEKSTTPQR SFTAETFLTT SSKPAILTWS NLLSTTPKEP
LTNTSLRWTD HITTQLTTSN RTQSAKLTKA NISSQTTNIY PQTITGRSTE V
