GO_HHV6U
ID GO_HHV6U Reviewed; 651 AA.
AC Q06093;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 23-FEB-2022, entry version 62.
DE RecName: Full=120 kDa Glycoprotein O;
DE Short=gO-120K;
DE AltName: Full=Glycoprotein U47;
DE Contains:
DE RecName: Full=80 kDa Glycoprotein O;
DE Short=gO-80K;
DE Flags: Precursor;
GN Name=U47; Synonyms=BHLF2;
OS Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS lymphotropic virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX NCBI_TaxID=10370;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1333836; DOI=10.3109/10425179209039693;
RA Gompels U.A., Carss A.L., Sun N., Arrand J.R.;
RT "Infectivity determinants encoded in a conserved gene block of human
RT herpesvirus-6.";
RL DNA Seq. 3:25-39(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT genome evolution.";
RL Virology 209:29-51(1995).
CC -!- SUBUNIT: [80 kDa Glycoprotein O]: Part of a gH-gL-gO complex.
CC {ECO:0000250|UniProtKB:P30005}.
CC -!- SUBCELLULAR LOCATION: [80 kDa Glycoprotein O]: Virion
CC {ECO:0000250|UniProtKB:P30005}. Host cell membrane
CC {ECO:0000250|UniProtKB:P30005}. Note=Expressed on the host cell surface
CC as a part of the gH-gL-gO complex. {ECO:0000250|UniProtKB:P30005}.
CC -!- PTM: [120 kDa Glycoprotein O]: A shorter mature protein, gO-80K, is
CC produced probably by proteolytic cleavage.
CC {ECO:0000250|UniProtKB:P30005}.
CC -!- PTM: [120 kDa Glycoprotein O]: Modified with high mannose-
CC oligosaccharides. {ECO:0000250|UniProtKB:P30005}.
CC -!- PTM: [80 kDa Glycoprotein O]: N-glycosylated with complex glycans.
CC {ECO:0000250|UniProtKB:P30005}.
CC -!- SIMILARITY: Belongs to the herpesviridae U47 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-34 is the initiator.
CC {ECO:0000305}.
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DR EMBL; X64320; CAA45602.1; -; Genomic_DNA.
DR EMBL; X83413; CAA58381.1; -; Genomic_DNA.
DR PIR; C56653; C56653.
DR RefSeq; NP_042940.2; NC_001664.2.
DR IntAct; Q06093; 1.
DR MINT; Q06093; -.
DR PRIDE; Q06093; -.
DR DNASU; 1487926; -.
DR GeneID; 1487926; -.
DR KEGG; vg:1487926; -.
DR Proteomes; UP000009295; Genome.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008645; Roseolovirus_U47.
DR Pfam; PF05467; Herpes_U47; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Host cell membrane; Host membrane; Membrane;
KW Reference proteome; Signal; Virion.
FT SIGNAL 1..56
FT /evidence="ECO:0000255"
FT CHAIN 57..651
FT /note="120 kDa Glycoprotein O"
FT /id="PRO_0000038316"
FT CHAIN 57..?
FT /note="80 kDa Glycoprotein O"
FT /id="PRO_0000445358"
FT REGION 275..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 208
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 395
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 502
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 520
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 603
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 620
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 631
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 651 AA; 73250 MW; A46043E2DFD47423 CRC64;
MHLEVIVQSY KKSKYYFSHT FYLYKFIVVN SPDMLHISRL GLFLGLFAIV MHSVNLIKYT
SDPLEAFKTV NRHNWSDEQR EHFYDLRNLY TSFCQTNLSL DCFTQILTNV FSWDIRDSQC
KSAVSLSPLQ NLPRTEIKIV LSSTTANKSI IASSFSLFYL LFATLSTYTA DPPCVELLPF
KILGAQLFDI KLTEESLRMA MSKFSNSNLT RSLTSFTSKN FFNYTSFVYF LLYNTTSCVP
SNDQYFKQSP KPINVTTSFG RAIVNFDSIL TTTPSSTSAS LTSPHIPSTN IPTPAPPPVT
KNSTKLHTDT IKVTPNTPTI TTQTTESIKK IVKRSDFPRP MYTPTDIPTL TIRLNATIKT
EQNTENPKSP PKPTNFENTT IRIPKTLESA TATTNATQKI ESTTFTTIGI KEINGNTYSS
PKNSIYLKSK SQQSTTKFTD AEHTTPILKF TTWQNTVRTY MSHNTEVQNM TDKFQRTTLK
SSNELPTIQT LSVTPKQKLP SNVTAKTEVH ITNNALPSSN SSYSITEVTK EVKHTRMSAS
THEQINHTEI AQITPILNAH TSEKSTTPQR SFTAETFLTT SSKPNIITWS NLLTTTPKEP
LTNTSLRWTD HITTQLTTSN RTQSAKLTKA NISSQTTNIY PQTITGRSTE V
