ID   GP04_BPT7               Reviewed;          51 AA.
AC   P03776;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Gene 0.4 protein;
DE   AltName: Full=Gene product 0.4;
DE            Short=Gp0.4;
OS   Escherichia phage T7 (Bacteriophage T7).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
OX   NCBI_TaxID=10760;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6864790; DOI=10.1016/s0022-2836(83)80282-4;
RA   Dunn J.J., Studier F.W.;
RT   "Complete nucleotide sequence of bacteriophage T7 DNA and the locations of
RT   T7 genetic elements.";
RL   J. Mol. Biol. 166:477-535(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7310871; DOI=10.1016/0022-2836(81)90178-9;
RA   Dunn J.J., Studier F.W.;
RT   "Nucleotide sequence from the genetic left end of bacteriophage T7 DNA to
RT   the beginning of gene 4.";
RL   J. Mol. Biol. 148:303-330(1981).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Korobko V.G., Chuvpilo S.A., Kolosov M.N.;
RT   "Nucleotide sequence of gene 0.4 of bacteriophage T7.";
RL   Bioorg. Khim. 6:1114-1116(1980).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7007389; DOI=10.1016/s0021-9258(19)69822-4;
RA   Dunn J.J., Elzinga M., Mark K.-K., Studier F.W.;
RT   "Amino acid sequence of the gene 0.3 protein of bacteriophage T7 and
RT   nucleotide sequence of its mRNA.";
RL   J. Biol. Chem. 256:2579-2585(1981).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH HOST FTSZ.
RX   PubMed=24218612; DOI=10.1073/pnas.1314096110;
RA   Kiro R., Molshanski-Mor S., Yosef I., Milam S.L., Erickson H.P., Qimron U.;
RT   "Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting
RT   host cell division.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:19549-19554(2013).
CC   -!- FUNCTION: Plays a role in the inhibition of host cell division.
CC       Interacts with and inhibits the major host cytoskeletal protein in
CC       bacterial division FtsZ to confer growth advantage to the phage.
CC       {ECO:0000269|PubMed:24218612}.
CC   -!- SUBUNIT: Interacts with host FtsZ. {ECO:0000269|PubMed:24218612}.
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DR   EMBL; V01146; CAA24385.1; -; Genomic_DNA.
DR   EMBL; V01127; CAA24328.1; -; Genomic_DNA.
DR   PIR; B43002; W0BP47.
DR   RefSeq; NP_041955.1; NC_001604.1.
DR   SMR; P03776; -.
DR   GeneID; 1261053; -.
DR   KEGG; vg:1261053; -.
DR   Proteomes; UP000000840; Genome.
DR   GO; GO:0044865; P:negative regulation by virus of host cell division; IDA:CACAO.
PE   1: Evidence at protein level;
KW   Early protein; Host-virus interaction; Reference proteome.
FT   CHAIN           1..51
FT                   /note="Gene 0.4 protein"
FT                   /id="PRO_0000106463"
SQ   SEQUENCE   51 AA;  5753 MW;  4C70D826CB395113 CRC64;
     MSTTNVQYGL TAQTVLFYSD MVRCGFNWSL AMAQLKELYE NNKAIALESA E