GP101_MOUSE
ID GP101_MOUSE Reviewed; 511 AA.
AC Q80T62; Q3UUI9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable G-protein coupled receptor 101;
GN Name=Gpr101; Synonyms=Gm365;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-217.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=25470569; DOI=10.1056/nejmoa1408028;
RA Trivellin G., Daly A.F., Faucz F.R., Yuan B., Rostomyan L., Larco D.O.,
RA Schernthaner-Reiter M.H., Szarek E., Leal L.F., Caberg J.H., Castermans E.,
RA Villa C., Dimopoulos A., Chittiboina P., Xekouki P., Shah N., Metzger D.,
RA Lysy P.A., Ferrante E., Strebkova N., Mazerkina N., Zatelli M.C.,
RA Lodish M., Horvath A., de Alexandre R.B., Manning A.D., Levy I., Keil M.F.,
RA Sierra M.L., Palmeira L., Coppieters W., Georges M., Naves L.A., Jamar M.,
RA Bours V., Wu T.J., Choong C.S., Bertherat J., Chanson P., Kamenicky P.,
RA Farrell W.E., Barlier A., Quezado M., Bjelobaba I., Stojilkovic S.S.,
RA Wess J., Costanzi S., Liu P., Lupski J.R., Beckers A., Stratakis C.A.;
RT "Gigantism and acromegaly due to Xq26 microduplications and GPR101
RT mutation.";
RL N. Engl. J. Med. 371:2363-2374(2014).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the brain in hypothalamus.
CC {ECO:0000269|PubMed:25470569}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AK138185; BAE23572.1; -; mRNA.
DR EMBL; AK138370; BAE23636.1; -; mRNA.
DR EMBL; AY255576; AAO85088.1; -; mRNA.
DR CCDS; CCDS30154.1; -.
DR RefSeq; NP_001028532.1; NM_001033360.3.
DR AlphaFoldDB; Q80T62; -.
DR STRING; 10090.ENSMUSP00000058183; -.
DR GlyGen; Q80T62; 2 sites.
DR iPTMnet; Q80T62; -.
DR PhosphoSitePlus; Q80T62; -.
DR PaxDb; Q80T62; -.
DR PRIDE; Q80T62; -.
DR ProteomicsDB; 271422; -.
DR Antibodypedia; 392; 251 antibodies from 31 providers.
DR Ensembl; ENSMUST00000057645; ENSMUSP00000058183; ENSMUSG00000036357.
DR GeneID; 245424; -.
DR KEGG; mmu:245424; -.
DR UCSC; uc009thn.2; mouse.
DR CTD; 83550; -.
DR MGI; MGI:2685211; Gpr101.
DR VEuPathDB; HostDB:ENSMUSG00000036357; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162539; -.
DR HOGENOM; CLU_009579_3_13_1; -.
DR InParanoid; Q80T62; -.
DR OMA; KVPQWVI; -.
DR OrthoDB; 1099940at2759; -.
DR PhylomeDB; Q80T62; -.
DR TreeFam; TF331895; -.
DR BioGRID-ORCS; 245424; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q80T62; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q80T62; protein.
DR Bgee; ENSMUSG00000036357; Expressed in arcuate nucleus of hypothalamus and 62 other tissues.
DR ExpressionAtlas; Q80T62; baseline and differential.
DR Genevisible; Q80T62; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..511
FT /note="Probable G-protein coupled receptor 101"
FT /id="PRO_0000069602"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..432
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 454..511
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 240..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 511 AA; 56245 MW; 0E224DE2FA43C7E6 CRC64;
MPPSCTNSTQ ENNGSRVCLP LSKMPISVAH GIIRSVVLLV ILGVAFLGNV VLGYVLHRKP
NLLQVTNRFI FNLLVTDLLQ VALVAPWVVS TAIPFFWPLN IHFCTALVSL THLFAFASVN
TIVVVSVDRY LTIIHPLSYP SKMTNRRSYI LLYGTWIAAF LQSTPPLYGW GHATFDDRNA
FCSMIWGASP AYTVVSVVSF LVIPLGVMIA CYSVVFGAAR RQQALLYKAK SHRLEVRVED
SVVHENEEGA KKRDEFQDKN EFQGQDGGGQ AEAKGSSSME ESPMVAEGSS QKTGKGSLDF
SAGIMEGKDS DEVSNGSMEG LEVITEFQAS SAKADTGRID ANQCNIDVGE DDVEFGMDEI
HFNDDVEAMR IPESSPPSRR NSTSDPPLPP CYECKAARVI FVIISTYVLS LGPYCFLAVL
AVWVDIDTRV PQWVITIIIW LFFLQCCIHP YVYGYMHKSI KKEIQEVLKK LICKKSPPVE
DSHPDLHETE AGTEGGIEGK AVPSHDSATS P
