ID   GP105_HHV6G             Reviewed;         650 AA.
AC   Q69489; Q69488;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Glycoprotein 105;
DE            Short=gp105;
GN   Name=U96/U97/U98/U99/U100;
OS   Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10369;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, SUBUNIT,
RP   AND GLYCOSYLATION.
RX   PubMed=7745696; DOI=10.1128/jvi.69.6.3490-3500.1995;
RA   Pfeiffer B., Thomson B., Chandran B.;
RT   "Identification and characterization of a cDNA derived from multiple
RT   splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6.";
RL   J. Virol. 69:3490-3500(1995).
CC   -!- SUBUNIT: Associates with the gp82-gp105 complex.
CC       {ECO:0000269|PubMed:7745696}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. The other components of
CC         the gp82-gp105 complex are most likely alternative products of the
CC         same gene.;
CC       Name=gp105;
CC         IsoId=Q69489-1; Sequence=Displayed;
CC   -!- PTM: N-Glycosylated. {ECO:0000269|PubMed:7745696}.
CC   -!- MISCELLANEOUS: [Isoform gp105]: Transcribed from a highly spliced mRNA.
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DR   EMBL; U23466; AAA92492.1; -; Genomic_DNA.
DR   EMBL; U23467; AAA92493.1; -; mRNA.
DR   PRIDE; Q69489; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Membrane; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..650
FT                   /note="Glycoprotein 105"
FT                   /id="PRO_0000343643"
FT   TRANSMEM        1..32
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..650
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        290
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        332
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        338
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        359
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        516
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        552
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   650 AA;  74563 MW;  3CC89EDB088B7E58 CRC64;
     MATARLGVMR PPRSCALIFL CAFSMATAPT NATAHRRAGT VKSTPPPEDK GNYTAKYYDK
     NIYFNIYEGR NSTPRRRTLW EIISKFSTSE MLSLKRVKAF VPVDDNPTTT LEDIADILNY
     AVCDDNSCGC TIETQARIMF GDIIICVPLS ADNKGVRNFK DRIMPKGLSQ ILSSSLGLHL
     SLLYGAFGSN YNSLAYMRRL KPLTAMTAIA FCPMTTKLEL RQNYKVKETL CELIVSIEIL
     KIRNNGGQTM KTLTSFAIVR KDNDGQDWET CTRFAPVNIE DILRYKRAAN DTCCRHRDVQ
     HGRRTLESSN SWTQTQYFEP WQDIVDVYVP INDTHCPNDS YVVFETLQGF EWCSRLNKNE
     TKNYLSSVLG FRNALFETEE LMETIAMRLA SQILSMVGQQ GTTIRDIDPA IVSALWHSLP
     ENLTTTNIKY DIASPTHMAP ALCTIFVQTG TSKERFRNAG LLMVNNIFTV QGRYTTQNMF
     ERKEYVYKHL GQALCQDGEI LFQNEGQKFC RPLTDNRTIV YTMQDQVQKP LSVTWMDFNL
     VISDYGRDVI NNLTKSAMLA RKNGPRYLQM ENGPRYLQME TFISDLFRHE CYQDNYYVLD
     KKLQMFYPTT HSNELLFIPR KLRCPHLGRN LRFPHLGRNL RFPHVGIGSY