GP107_MOUSE
ID GP107_MOUSE Reviewed; 551 AA.
AC Q8BUV8; Q6ZPL4; Q8BM58; Q8BMN6; Q8BTW1;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein GPR107;
DE Flags: Precursor;
GN Name=Gpr107; Synonyms=Kiaa1624;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryoid bodies, Pituitary, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-551.
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=26561648; DOI=10.1152/ajpregu.00369.2014;
RA Elrick M.M., Samson W.K., Corbett J.A., Salvatori A.S., Stein L.M.,
RA Kolar G.R., Naatz A., Yosten G.L.;
RT "Neuronostatin acts via GPR107 to increase cAMP-independent PKA
RT phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-
RT cells.";
RL Am. J. Physiol. 310:R143-R155(2016).
CC -!- FUNCTION: Has been proposed to act as a receptor for neuronostatin, a
CC peptide derived from the somatostatin/SST precursor (By similarity).
CC Involved in blood sugar regulation through the induction of glucagon in
CC response to low glucose (By similarity).
CC {ECO:0000250|UniProtKB:D3ZWZ9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:26561648};
CC Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000250|UniProtKB:Q5VW38}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- PTM: Cleaved by FURIN to yield two fragments that remain associated via
CC a disulfide bond. {ECO:0000250|UniProtKB:Q5VW38}.
CC -!- SIMILARITY: Belongs to the LU7TM family. {ECO:0000305}.
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DR EMBL; AK030433; BAC26961.1; -; mRNA.
DR EMBL; AK034815; BAC28840.1; -; mRNA.
DR EMBL; AK082237; BAC38445.1; -; mRNA.
DR EMBL; AK088544; BAC40414.1; -; mRNA.
DR EMBL; BC092231; AAH92231.1; -; mRNA.
DR EMBL; AK129407; BAC98217.1; -; mRNA.
DR CCDS; CCDS15895.1; -.
DR RefSeq; NP_848875.2; NM_178760.4.
DR AlphaFoldDB; Q8BUV8; -.
DR BioGRID; 234940; 1.
DR STRING; 10090.ENSMUSP00000056739; -.
DR GlyGen; Q8BUV8; 2 sites.
DR iPTMnet; Q8BUV8; -.
DR PhosphoSitePlus; Q8BUV8; -.
DR EPD; Q8BUV8; -.
DR jPOST; Q8BUV8; -.
DR MaxQB; Q8BUV8; -.
DR PaxDb; Q8BUV8; -.
DR PRIDE; Q8BUV8; -.
DR ProteomicsDB; 271423; -.
DR Antibodypedia; 31467; 153 antibodies from 26 providers.
DR Ensembl; ENSMUST00000056433; ENSMUSP00000056739; ENSMUSG00000000194.
DR GeneID; 277463; -.
DR KEGG; mmu:277463; -.
DR UCSC; uc008jdp.2; mouse.
DR CTD; 57720; -.
DR MGI; MGI:2139054; Gpr107.
DR VEuPathDB; HostDB:ENSMUSG00000000194; -.
DR eggNOG; KOG2569; Eukaryota.
DR GeneTree; ENSGT00940000160451; -.
DR HOGENOM; CLU_020277_4_1_1; -.
DR InParanoid; Q8BUV8; -.
DR OMA; PQGEWES; -.
DR OrthoDB; 1427067at2759; -.
DR PhylomeDB; Q8BUV8; -.
DR TreeFam; TF314804; -.
DR BioGRID-ORCS; 277463; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BUV8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BUV8; protein.
DR Bgee; ENSMUSG00000000194; Expressed in spermatocyte and 224 other tissues.
DR ExpressionAtlas; Q8BUV8; baseline and differential.
DR Genevisible; Q8BUV8; MM.
DR GO; GO:0030136; C:clathrin-coated vesicle; IDA:MGI.
DR GO; GO:0005769; C:early endosome; IDA:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032050; F:clathrin heavy chain binding; IDA:MGI.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IMP:MGI.
DR InterPro; IPR009637; GPR107/GPR108-like.
DR PANTHER; PTHR21229; PTHR21229; 1.
DR Pfam; PF06814; Lung_7-TM_R; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..551
FT /note="Protein GPR107"
FT /id="PRO_0000021341"
FT TOPO_DOM 40..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..336
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..401
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..449
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 471..475
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..495
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 496..551
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 537
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..226
FT /evidence="ECO:0000250|UniProtKB:Q5VW38"
FT CONFLICT 127
FT /note="I -> L (in Ref. 1; BAC38445)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="Q -> R (in Ref. 1; BAC40414 and 3; BAC98217)"
FT /evidence="ECO:0000305"
FT CONFLICT 532
FT /note="K -> R (in Ref. 1; BAC28840)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 551 AA; 62056 MW; B79DBE97D56BD2B6 CRC64;
MAVPVPLGRF GSFCLRLLRL LALLELLVHP VLGRVHHLAL KDDVRHKVHL NTFGFFKDGY
MVVNVSSLSV NEPEGATDKD AEIGFSLDRT KNDGFSSYLD EDVNYCILKK KSMSSVTLVI
LDISGSIVKV RSPPEAGKQL PEIVFSKDEK ILSQSQEPAV SSNPKDSEAR RTLDGFKAGR
STVDSKAITE RSFSIHKNDG VVSFQFFFNI STDDQEGLYS LYFHKCSGNN VKPGEQASFS
LNIAITEKNP NSYLSAGEIP LPKLYVSMAL FFFLSGTIWI HILRKRRNDV FKIHWLMAAL
PFTKSLSLVF HAIDYHYISS QGFPIEGWAV VYYITHLLKG ALLFITIALI GTGWAFIKHI
LSDKDKKIFM IVIPLQVLAN VAYIIIESTE EGTTEYGLWK DSLFLVDLLC CGAILFPVVW
SIRHLQEASA TDGKAAINLA KLRLFRHYYV LIVCYIYFTR IIAFLLKFAV PFQWKWLYQL
LDETATLVFF VLTGYKFRPA SDNPYLQLSQ EDDDLEMESV VTTSGVMENM KKVKKVSNGA
VEPQGSWEGT A
