GP108_BOVIN
ID GP108_BOVIN Reviewed; 548 AA.
AC Q148L1; Q0V8H5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Protein GPR108;
DE Flags: Precursor;
GN Name=GPR108;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-548.
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: May play a role in intracellular immune modulation by
CC activating NF-kappaB response and attenuating Toll-like-receptor
CC response. {ECO:0000250|UniProtKB:Q91WD0}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q91WD0}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q9NPR9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9NPR9}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Colocalizes with TLR3, -7, -4, and -9.
CC {ECO:0000250|UniProtKB:Q91WD0}.
CC -!- SIMILARITY: Belongs to the LU7TM family. {ECO:0000305}.
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DR EMBL; BC118184; AAI18185.1; -; mRNA.
DR EMBL; BT026243; ABG67082.1; -; mRNA.
DR RefSeq; NP_001068801.1; NM_001075333.1.
DR AlphaFoldDB; Q148L1; -.
DR STRING; 9913.ENSBTAP00000022987; -.
DR PaxDb; Q148L1; -.
DR PRIDE; Q148L1; -.
DR Ensembl; ENSBTAT00000071276; ENSBTAP00000067674; ENSBTAG00000017291.
DR GeneID; 507830; -.
DR KEGG; bta:507830; -.
DR CTD; 56927; -.
DR VEuPathDB; HostDB:ENSBTAG00000017291; -.
DR VGNC; VGNC:29545; GPR108.
DR eggNOG; KOG2569; Eukaryota.
DR GeneTree; ENSGT00940000160446; -.
DR HOGENOM; CLU_020277_0_0_1; -.
DR InParanoid; Q148L1; -.
DR OMA; CKARIHK; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000017291; Expressed in urinary bladder and 104 other tissues.
DR ExpressionAtlas; Q148L1; baseline and differential.
DR GO; GO:0033106; C:cis-Golgi network membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
DR InterPro; IPR009637; GPR107/GPR108-like.
DR PANTHER; PTHR21229; PTHR21229; 1.
DR Pfam; PF06814; Lung_7-TM_R; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..548
FT /note="Protein GPR108"
FT /id="PRO_0000278794"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 165..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 539
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 53
FT /note="G -> D (in Ref. 2; ABG67082)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 548 AA; 61403 MW; C6901F53D3EAED3D CRC64;
MAVSERRGLG RGSPAEWGPW LLLLLLLGGS SGRIHRLTLT GEKRADIQLN SFGFYTNGSL
EVNLSLLRLG RQDTEEKAPL VGFSLTRVRS GSIRSYSNRD SHECPLRKNS SSLLVLFLIN
TKDLEVQVRK YGEQKKLFIS AGLLPESPSK PGLPKSEHMV TPKVDHAGTT AAPDKAKSKP
TGLQGDRQGV SGKDQELVLG LGHLNNSYNF SFHVVIGSRA EEGQYNLNFH NCDNSVPGRE
QPFDITVMIR EKNPEGYLSA AEIPLFKLYM VMSACFLGAG IFWVSILCKN TYNVFKIHWL
MAALTFTKSV SLLFHSINYY FINSQGHPIE GLAVMHYITH LLKGALLFIT IALIGSGWAF
VKYVLSDKEK KIFGIVIPLQ VLANVAYIVM ESREEGASDY GIWKEILFLV DLICCGTILF
PVVWSIRHLQ DASGTDGKVA VNLAKLKLFR HYYVMVICYI YFTRIIAILL RAVVPFQWQW
LYQLLVEGST LAFFVLTGYK FQPARDNPYL QLPQEDEEGM QIEQVMTDSG FREGLSKVNK
TASGRELL
