GP119_RAT
ID GP119_RAT Reviewed; 468 AA.
AC Q7TQN8;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Glucose-dependent insulinotropic receptor;
DE AltName: Full=G-protein coupled receptor 119;
GN Name=Gpr119;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT lacking close relatives.";
RL FEBS Lett. 554:381-388(2003).
RN [2]
RP TISSUE SPECIFICITY, AND CHARACTERIZATION.
RX PubMed=15607732; DOI=10.1016/j.bbrc.2004.11.120;
RA Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J.,
RA Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y.,
RA Matsushime H., Kobori M., Furuichi K.;
RT "Lysophosphatidylcholine enhances glucose-dependent insulin secretion via
RT an orphan G-protein-coupled receptor.";
RL Biochem. Biophys. Res. Commun. 326:744-751(2005).
RN [3]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=17289847; DOI=10.1210/en.2006-1608;
RA Chu Z.L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A.,
RA Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K.,
RA Semple G., Behan D.P., Leonard J.;
RT "A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic
RT control by enhancing glucose-dependent insulin release.";
RL Endocrinology 148:2601-2609(2007).
CC -!- FUNCTION: Receptor for the endogenous fatty-acid ethanolamide
CC oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions
CC as a glucose-dependent insulinotropic receptor. The activity of this
CC receptor is mediated by G proteins which activate adenylate cyclase.
CC Seems to act through a G(s) mediated pathway.
CC {ECO:0000269|PubMed:17289847}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expression restricted to the beta-cells of
CC pancreatic islets. {ECO:0000269|PubMed:15607732,
CC ECO:0000269|PubMed:17289847}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY288429; AAP72138.1; -; mRNA.
DR RefSeq; NP_861435.1; NM_181770.1.
DR AlphaFoldDB; Q7TQN8; -.
DR SMR; Q7TQN8; -.
DR STRING; 10116.ENSRNOP00000036164; -.
DR BindingDB; Q7TQN8; -.
DR ChEMBL; CHEMBL5262; -.
DR PhosphoSitePlus; Q7TQN8; -.
DR PaxDb; Q7TQN8; -.
DR Ensembl; ENSRNOT00000033619; ENSRNOP00000036164; ENSRNOG00000024517.
DR GeneID; 302813; -.
DR KEGG; rno:302813; -.
DR UCSC; RGD:727808; rat.
DR CTD; 139760; -.
DR RGD; 727808; Gpr119.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234510; -.
DR HOGENOM; CLU_583888_0_0_1; -.
DR InParanoid; Q7TQN8; -.
DR OMA; HLAIRKP; -.
DR OrthoDB; 1245021at2759; -.
DR PhylomeDB; Q7TQN8; -.
DR TreeFam; TF325411; -.
DR Reactome; R-RNO-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
DR Reactome; R-RNO-400511; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
DR PRO; PR:Q7TQN8; -.
DR Proteomes; UP000002494; Chromosome X.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0031210; F:phosphatidylcholine binding; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0030073; P:insulin secretion; ISO:RGD.
DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR028336; GPR119.
DR PANTHER; PTHR22750:SF7; PTHR22750:SF7; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Lipid-binding; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..468
FT /note="Glucose-dependent insulinotropic receptor"
FT /id="PRO_0000069609"
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 468 AA; 51686 MW; 6D5E607B572BE45A CRC64;
MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA DTLIGVAISG
LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA FDRYLAIKQP LRYFQIMNGL
VAGGCIAGLW LISYLIGFLP LGVSIFQQTT YHGPCTFFAV FHPRFVLTLS CAGFFPAVLL
FVFFYCDMLK IASVHSQHIR KMEHAGAMVG ACRPPRPVND FKAVRTVSVL IGSFTLSWSP
FLITSIVQVA CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL CHMALGLLAD
GSTQPQIETL KGKEERKKVG RKTLYTCDAQ TLYTCDAQTL YTCDAQTLYT CDACDTQTLY
TCDAQTLYTC DAQTLYTCDA QTLYTCDAQT LYTCDAQTLY TCDTQTLYTC DAQTLYTCDA
QTLYTCDAQT LYTCDAQTLY TSSLVTGQTE QTPLKRANMS DPLRTCRG
