GP135_HUMAN
ID GP135_HUMAN Reviewed; 494 AA.
AC Q8IZ08; Q7Z604; Q86SM3; Q8NH39;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=G-protein coupled receptor 135 {ECO:0000305};
GN Name=GPR135;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT lacking close relatives.";
RL FEBS Lett. 554:381-388(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-280.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [6]
RP SUBCELLULAR LOCATION, INTERACTION WITH MTNR1B, INTERACTION WITH ARRB1 AND
RP ARRB2, AND FUNCTION.
RX PubMed=28827538; DOI=10.1038/s41598-017-08996-7;
RA Oishi A., Karamitri A., Gerbier R., Lahuna O., Ahmad R., Jockers R.;
RT "Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor
RT reciprocally modulate their signaling functions.";
RL Sci. Rep. 7:8990-8990(2017).
CC -!- FUNCTION: Orphan receptor. Has spontaneous activity for beta-arrestin
CC recruitment (PubMed:28827538). Shows a reciprocal regulatory
CC interaction with the melatonin receptor MTNR1B most likely through
CC receptor heteromerization (PubMed:28827538).
CC {ECO:0000269|PubMed:28827538}.
CC -!- SUBUNIT: Interacts with MTNR1B (PubMed:28827538). Interacts with ARRB1
CC and ARRB2 in a spontaneous and agonist-independent manner; leading to
CC the internalization of GPR135 in the endosomal compartment
CC (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538};
CC Multi-pass membrane protein {ECO:0000255}. Endosome membrane
CC {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Colocalizes with ARRB2/beta-arrestin-2 in the
CC endosome. {ECO:0000269|PubMed:28827538}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY288418; AAP72127.1; -; mRNA.
DR EMBL; AB065563; BAC05800.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL159140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032831; AAH32831.2; -; mRNA.
DR EMBL; AY255588; AAO85100.1; -; mRNA.
DR CCDS; CCDS9738.1; -.
DR RefSeq; NP_072093.2; NM_022571.5.
DR RefSeq; XP_016877085.1; XM_017021596.1.
DR RefSeq; XP_016877086.1; XM_017021597.1.
DR RefSeq; XP_016877087.1; XM_017021598.1.
DR RefSeq; XP_016877088.1; XM_017021599.1.
DR AlphaFoldDB; Q8IZ08; -.
DR SMR; Q8IZ08; -.
DR BioGRID; 122207; 6.
DR IntAct; Q8IZ08; 4.
DR STRING; 9606.ENSP00000378548; -.
DR BindingDB; Q8IZ08; -.
DR ChEMBL; CHEMBL3309102; -.
DR iPTMnet; Q8IZ08; -.
DR PhosphoSitePlus; Q8IZ08; -.
DR BioMuta; GPR135; -.
DR DMDM; 62900365; -.
DR EPD; Q8IZ08; -.
DR PaxDb; Q8IZ08; -.
DR PeptideAtlas; Q8IZ08; -.
DR PRIDE; Q8IZ08; -.
DR ProteomicsDB; 71266; -.
DR Antibodypedia; 24279; 98 antibodies from 24 providers.
DR DNASU; 64582; -.
DR Ensembl; ENST00000395116.2; ENSP00000378548.1; ENSG00000181619.12.
DR Ensembl; ENST00000481661.1; ENSP00000432696.1; ENSG00000181619.12.
DR GeneID; 64582; -.
DR KEGG; hsa:64582; -.
DR MANE-Select; ENST00000395116.2; ENSP00000378548.1; NM_022571.6; NP_072093.2.
DR UCSC; uc001xed.3; human.
DR CTD; 64582; -.
DR DisGeNET; 64582; -.
DR GeneCards; GPR135; -.
DR HGNC; HGNC:19991; GPR135.
DR HPA; ENSG00000181619; Low tissue specificity.
DR MIM; 607970; gene.
DR neXtProt; NX_Q8IZ08; -.
DR OpenTargets; ENSG00000181619; -.
DR PharmGKB; PA134863427; -.
DR VEuPathDB; HostDB:ENSG00000181619; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182998; -.
DR HOGENOM; CLU_048891_0_0_1; -.
DR InParanoid; Q8IZ08; -.
DR OMA; EVAMWAC; -.
DR OrthoDB; 770796at2759; -.
DR PhylomeDB; Q8IZ08; -.
DR TreeFam; TF333332; -.
DR PathwayCommons; Q8IZ08; -.
DR SignaLink; Q8IZ08; -.
DR BioGRID-ORCS; 64582; 17 hits in 1074 CRISPR screens.
DR ChiTaRS; GPR135; human.
DR GeneWiki; GPR135; -.
DR GenomeRNAi; 64582; -.
DR Pharos; Q8IZ08; Tbio.
DR PRO; PR:Q8IZ08; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8IZ08; protein.
DR Bgee; ENSG00000181619; Expressed in left testis and 98 other tissues.
DR Genevisible; Q8IZ08; HS.
DR GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:1990763; F:arrestin family protein binding; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endosome; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..494
FT /note="G-protein coupled receptor 135"
FT /id="PRO_0000069612"
FT TOPO_DOM 1..12
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..494
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 5
FT /note="Q -> P (in dbSNP:rs1752428)"
FT /id="VAR_024259"
FT VARIANT 481
FT /note="V -> A (in dbSNP:rs1752427)"
FT /id="VAR_049402"
SQ SEQUENCE 494 AA; 51736 MW; 439A932E2860D4DF CRC64;
MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA ALGNLSDASG
GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG AAVAAQALVL LLIFLLSSLG
NCAVMGVIVK HRQLRTVTNA FILSLSLSDL LTALLCLPAA FLDLFTPPGG SAPAAAAGPW
RGFCAASRFF SSCFGIVSTL SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF
SLPWELLGAP RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI
CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL VLLAAARQAQ
TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR NREEGYRTRN VDAFLPSQGP
GLQARSRSRL RNRYANRLGA CNRMSSSNPA SGVAGDVAMW ARKNPVVLFC REGPPEPVTA
VTKQPKSEAG DTSL
