GP135_MOUSE
ID GP135_MOUSE Reviewed; 457 AA.
AC Q7TQP2;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=G-protein coupled receptor 135;
GN Name=Gpr135;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT lacking close relatives.";
RL FEBS Lett. 554:381-388(2003).
CC -!- FUNCTION: Orphan receptor. Has spontaneous activity for beta-arrestin
CC recruitment (By similarity). Shows a reciprocal regulatory interaction
CC with the melatonin receptor MTNR1B most likely through receptor
CC heteromerization (By similarity). {ECO:0000250|UniProtKB:Q8IZ08}.
CC -!- SUBUNIT: Interacts with MTNR1B. Interacts with ARRB1 and ARRB2 in a
CC spontaneous and agonist-independent manner; leading to the
CC internalization of GPR135 in the endosomal compartment (By similarity).
CC {ECO:0000250|UniProtKB:Q8IZ08}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZ08};
CC Multi-pass membrane protein {ECO:0000255}. Endosome membrane
CC {ECO:0000250|UniProtKB:Q8IZ08}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Colocalizes with ARRB2/beta-arrestin-2 in the
CC endosome (By similarity). {ECO:0000250|UniProtKB:Q8IZ08}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY288425; AAP72134.1; -; mRNA.
DR CCDS; CCDS25965.1; -.
DR RefSeq; NP_861417.1; NM_181752.1.
DR AlphaFoldDB; Q7TQP2; -.
DR SMR; Q7TQP2; -.
DR STRING; 10090.ENSMUSP00000058762; -.
DR GlyGen; Q7TQP2; 1 site.
DR PhosphoSitePlus; Q7TQP2; -.
DR PaxDb; Q7TQP2; -.
DR PRIDE; Q7TQP2; -.
DR Antibodypedia; 24279; 98 antibodies from 24 providers.
DR DNASU; 238252; -.
DR Ensembl; ENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398.
DR GeneID; 238252; -.
DR KEGG; mmu:238252; -.
DR UCSC; uc007nvc.1; mouse.
DR CTD; 64582; -.
DR MGI; MGI:2676315; Gpr135.
DR VEuPathDB; HostDB:ENSMUSG00000043398; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182998; -.
DR HOGENOM; CLU_048891_0_0_1; -.
DR InParanoid; Q7TQP2; -.
DR OMA; EVAMWAC; -.
DR OrthoDB; 770796at2759; -.
DR PhylomeDB; Q7TQP2; -.
DR TreeFam; TF333332; -.
DR BioGRID-ORCS; 238252; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q7TQP2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q7TQP2; protein.
DR Bgee; ENSMUSG00000043398; Expressed in metanephric proximal tubule and 147 other tissues.
DR ExpressionAtlas; Q7TQP2; baseline and differential.
DR GO; GO:0005768; C:endosome; ISO:MGI.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:1990763; F:arrestin family protein binding; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endosome; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..457
FT /note="G-protein coupled receptor 135"
FT /id="PRO_0000069613"
FT TOPO_DOM 1..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..156
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..329
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..457
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 457 AA; 49361 MW; D8555CD6EE4BDA14 CRC64;
MEEQARPPGR PAASATLQGS AHPGGAASTA TAAALSFSSV ATVTLGNQSD AGRPEAAGSR
GPAPLLWHGA AVAAQALVLL LIFLLSSLGN CAVMGVIVKH RQLRTVTNAF ILSLSLSDLL
TALLCLPAAF LDLFAPPGDS GPWRSFCAAS RFFSSCFGIV STFSVALISL DRYCAIVRPP
RDKLGRRRAL QLLAGAWLAA LGFSLPWDLL RAPREPPAPQ SFHRCLYRTS PDPAQLGVAY
SVGLVVACYL LPFLLMCFCR YHICKTVRLS DVRVRPMTTY ARVLRFFSEV RTATTVLIMI
IFVMCCWGPY CFLVLLAATR QGQATQAPSL LNVAAVWLTW ANGAINPVIY AIRNPNISML
LGRNREEGYR TRNMDAFLPS QGLGFQARSR NRLRNGCANR LGACSRMPSS NPASGSGGEV
VMWARKNPVV LFFREGPPDS VMEVGKLHNS ETRDSSI
