GP139_HUMAN
ID GP139_HUMAN Reviewed; 353 AA.
AC Q6DWJ6; A8K5R9; Q86SP2; Q8TDU8;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable G-protein coupled receptor 139;
DE AltName: Full=G(q)-coupled orphan receptor GPRg1;
DE AltName: Full=G-protein-coupled receptor PGR3;
GN Name=GPR139; Synonyms=GPRG1, PGR3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Bonner T.I., Nagle J.W., Kauffman D.;
RT "Complete coding sequence of GPR139.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15845401; DOI=10.1016/j.bbrc.2005.03.174;
RA Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J.,
RA Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.;
RT "Molecular cloning and characterization of a novel Gq-coupled orphan
RT receptor GPRg1 exclusively expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 331:363-369(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 168-353.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor. Seems to act through a G(q/11)-mediated
CC pathway.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed almost exclusively in the brain. Detected
CC at very low levels in the peripheral tissues.
CC {ECO:0000269|PubMed:15845401}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB89307.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY635179; AAT65818.1; -; mRNA.
DR EMBL; AB196529; BAD97440.1; -; mRNA.
DR EMBL; AB083594; BAB89307.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK291384; BAF84073.1; -; mRNA.
DR EMBL; CH471186; EAW50306.1; -; Genomic_DNA.
DR EMBL; BC137237; AAI37238.1; -; mRNA.
DR EMBL; BC137238; AAI37239.1; -; mRNA.
DR EMBL; AY255545; AAO85057.1; -; mRNA.
DR CCDS; CCDS32398.1; -.
DR RefSeq; NP_001002911.1; NM_001002911.3.
DR RefSeq; NP_001305412.1; NM_001318483.1.
DR PDB; 7VUG; EM; 3.20 A; R=2-321.
DR PDB; 7VUH; EM; 3.22 A; R=2-321.
DR PDB; 7VUI; EM; 3.30 A; R=2-321.
DR PDB; 7VUJ; EM; 3.80 A; R=2-321.
DR PDBsum; 7VUG; -.
DR PDBsum; 7VUH; -.
DR PDBsum; 7VUI; -.
DR PDBsum; 7VUJ; -.
DR AlphaFoldDB; Q6DWJ6; -.
DR SMR; Q6DWJ6; -.
DR BioGRID; 125859; 16.
DR STRING; 9606.ENSP00000458791; -.
DR BindingDB; Q6DWJ6; -.
DR ChEMBL; CHEMBL3632455; -.
DR DrugCentral; Q6DWJ6; -.
DR GuidetoPHARMACOLOGY; 130; -.
DR TCDB; 9.A.14.13.25; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q6DWJ6; 1 site.
DR iPTMnet; Q6DWJ6; -.
DR PhosphoSitePlus; Q6DWJ6; -.
DR BioMuta; GPR139; -.
DR DMDM; 74762300; -.
DR MassIVE; Q6DWJ6; -.
DR PaxDb; Q6DWJ6; -.
DR PRIDE; Q6DWJ6; -.
DR Antibodypedia; 12144; 153 antibodies from 30 providers.
DR DNASU; 124274; -.
DR Ensembl; ENST00000570682.2; ENSP00000458791.2; ENSG00000180269.8.
DR GeneID; 124274; -.
DR KEGG; hsa:124274; -.
DR MANE-Select; ENST00000570682.2; ENSP00000458791.2; NM_001002911.4; NP_001002911.1.
DR UCSC; uc002dgu.2; human.
DR CTD; 124274; -.
DR DisGeNET; 124274; -.
DR GeneCards; GPR139; -.
DR HGNC; HGNC:19995; GPR139.
DR HPA; ENSG00000180269; Tissue enriched (brain).
DR MIM; 618448; gene.
DR neXtProt; NX_Q6DWJ6; -.
DR OpenTargets; ENSG00000180269; -.
DR PharmGKB; PA134970866; -.
DR VEuPathDB; HostDB:ENSG00000180269; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000159473; -.
DR HOGENOM; CLU_009579_24_1_1; -.
DR InParanoid; Q6DWJ6; -.
DR OMA; LMEDFIL; -.
DR OrthoDB; 790152at2759; -.
DR PhylomeDB; Q6DWJ6; -.
DR TreeFam; TF334275; -.
DR PathwayCommons; Q6DWJ6; -.
DR BioGRID-ORCS; 124274; 4 hits in 1057 CRISPR screens.
DR ChiTaRS; GPR139; human.
DR GeneWiki; GPR139; -.
DR GenomeRNAi; 124274; -.
DR Pharos; Q6DWJ6; Tchem.
DR PRO; PR:Q6DWJ6; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6DWJ6; protein.
DR Bgee; ENSG00000180269; Expressed in cortical plate and 13 other tissues.
DR ExpressionAtlas; Q6DWJ6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008188; F:neuropeptide receptor activity; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15919; 7tmA_GPR139; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR037486; GPR139.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..353
FT /note="Probable G-protein coupled receptor 139"
FT /id="PRO_0000069615"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT HELIX 24..26
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 27..51
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 54..57
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 61..80
FT /evidence="ECO:0007829|PDB:7VUG"
FT TURN 81..83
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 84..87
FT /evidence="ECO:0007829|PDB:7VUG"
FT TURN 88..91
FT /evidence="ECO:0007829|PDB:7VUG"
FT TURN 97..99
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 100..131
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 133..135
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 136..139
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 142..159
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 161..165
FT /evidence="ECO:0007829|PDB:7VUG"
FT TURN 169..173
FT /evidence="ECO:0007829|PDB:7VUH"
FT HELIX 178..191
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 193..211
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 221..241
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 243..253
FT /evidence="ECO:0007829|PDB:7VUG"
FT STRAND 256..258
FT /evidence="ECO:0007829|PDB:7VUH"
FT HELIX 260..286
FT /evidence="ECO:0007829|PDB:7VUG"
FT HELIX 290..303
FT /evidence="ECO:0007829|PDB:7VUG"
SQ SEQUENCE 353 AA; 40679 MW; CF1088FCE5C84F85 CRC64;
MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII LSQLVARRQK
SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP DKIIEVLEFS SIHTSIWITV
PLTIDRYIAV CHPLKYHTVS YPARTRKVIV SVYITCFLTS IPYYWWPNIW TEDYISTSVH
HVLIWIHCFT VYLVPCSIFF ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL
WAPRIIMILY HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL
KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK VSP
