GP139_MOUSE
ID GP139_MOUSE Reviewed; 345 AA.
AC Q80UC8; Q059X1;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable G-protein coupled receptor 139;
DE AltName: Full=G(q)-coupled orphan receptor GPRg1;
DE AltName: Full=G-protein-coupled receptor PGR3;
GN Name=Gpr139; Synonyms=Gm495, Gprg1, Pgr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15845401; DOI=10.1016/j.bbrc.2005.03.174;
RA Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J.,
RA Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.;
RT "Molecular cloning and characterization of a novel Gq-coupled orphan
RT receptor GPRg1 exclusively expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 331:363-369(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 218-271.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor. Seems to act through a G(q/11)-mediated
CC pathway.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed almost exclusively in the brain.
CC Abundantly expressed in the ventrolateral region of caudate putamen,
CC the habenular nucleus, the zona incerta, and the medial mammillary
CC nucleus. {ECO:0000269|PubMed:15845401}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB196532; BAD97443.1; -; mRNA.
DR EMBL; BC125496; AAI25497.1; -; mRNA.
DR EMBL; BC125498; AAI25499.1; -; mRNA.
DR EMBL; AY255548; AAO85060.1; -; mRNA.
DR CCDS; CCDS21778.1; -.
DR RefSeq; NP_001019309.1; NM_001024138.1.
DR AlphaFoldDB; Q80UC8; -.
DR SMR; Q80UC8; -.
DR STRING; 10090.ENSMUSP00000081700; -.
DR GlyGen; Q80UC8; 1 site.
DR PhosphoSitePlus; Q80UC8; -.
DR PaxDb; Q80UC8; -.
DR PRIDE; Q80UC8; -.
DR ProteomicsDB; 267746; -.
DR Antibodypedia; 12144; 153 antibodies from 30 providers.
DR DNASU; 209776; -.
DR Ensembl; ENSMUST00000084650; ENSMUSP00000081700; ENSMUSG00000066197.
DR GeneID; 209776; -.
DR KEGG; mmu:209776; -.
DR UCSC; uc009jky.1; mouse.
DR CTD; 124274; -.
DR MGI; MGI:2685341; Gpr139.
DR VEuPathDB; HostDB:ENSMUSG00000066197; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000159473; -.
DR HOGENOM; CLU_009579_24_1_1; -.
DR InParanoid; Q80UC8; -.
DR OMA; LMEDFIL; -.
DR OrthoDB; 790152at2759; -.
DR PhylomeDB; Q80UC8; -.
DR TreeFam; TF334275; -.
DR BioGRID-ORCS; 209776; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q80UC8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80UC8; protein.
DR Bgee; ENSMUSG00000066197; Expressed in lumbar dorsal root ganglion and 44 other tissues.
DR ExpressionAtlas; Q80UC8; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0008188; F:neuropeptide receptor activity; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR CDD; cd15919; 7tmA_GPR139; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR037486; GPR139.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="Probable G-protein coupled receptor 139"
FT /id="PRO_0000069616"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 345 AA; 39758 MW; 764D568B29EB6036 CRC64;
MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR QKSSYNYLLA
LAAADILVLF FIVFVDFLLE DFILTMQMPL IPDKIIEVLE FSSIHTSIWI TVPLTVDRYI
AVCHPLKYHT VSYPARTRKV ILSVYITCFL TSIPYYWWPN IWTEDYISTS MHHVLVWIHC
FTVYLVPCSI FFILNSIIVY KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI
LYHLYGAPIQ NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP
