ID   GP139_RAT               Reviewed;         345 AA.
AC   P0C0W8;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Probable G-protein coupled receptor 139;
DE   AltName: Full=G(q)-coupled orphan receptor GPRg1;
GN   Name=Gpr139; Synonyms=Gprg1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15845401; DOI=10.1016/j.bbrc.2005.03.174;
RA   Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J.,
RA   Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.;
RT   "Molecular cloning and characterization of a novel Gq-coupled orphan
RT   receptor GPRg1 exclusively expressed in the central nervous system.";
RL   Biochem. Biophys. Res. Commun. 331:363-369(2005).
CC   -!- FUNCTION: Orphan receptor. Seems to act through a G(q/11)-mediated
CC       pathway.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AB196531; BAD97442.1; -; mRNA.
DR   RefSeq; NP_001019412.1; NM_001024241.1.
DR   AlphaFoldDB; P0C0W8; -.
DR   SMR; P0C0W8; -.
DR   STRING; 10116.ENSRNOP00000037722; -.
DR   GlyGen; P0C0W8; 1 site.
DR   PhosphoSitePlus; P0C0W8; -.
DR   PaxDb; P0C0W8; -.
DR   Ensembl; ENSRNOT00000032796; ENSRNOP00000037722; ENSRNOG00000023863.
DR   GeneID; 293545; -.
DR   KEGG; rno:293545; -.
DR   UCSC; RGD:1311729; rat.
DR   CTD; 124274; -.
DR   RGD; 1311729; Gpr139.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000159473; -.
DR   HOGENOM; CLU_009579_24_1_1; -.
DR   InParanoid; P0C0W8; -.
DR   OMA; LMEDFIL; -.
DR   OrthoDB; 790152at2759; -.
DR   PhylomeDB; P0C0W8; -.
DR   TreeFam; TF334275; -.
DR   PRO; PR:P0C0W8; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000023863; Expressed in cerebellum.
DR   ExpressionAtlas; P0C0W8; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0008188; F:neuropeptide receptor activity; ISO:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR   CDD; cd15919; 7tmA_GPR139; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR037486; GPR139.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..345
FT                   /note="Probable G-protein coupled receptor 139"
FT                   /id="PRO_0000069617"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..173
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..220
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        242..260
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..345
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   345 AA;  39742 MW;  270D568005EB6031 CRC64;
     MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR QKSSYNYLLA
     LAAADILVLF FIVFVDFLLE DFILTMQMPP IPDKIIEVLE FSSIHTSIWI TVPLTVDRYI
     AVCHPLKYHT VSYPARTRKV ILSVYITCFL TSIPYYWWPN IWTEDYISTS MHHVLVWIHC
     FTVYLVPCSI FFILNSIIVY KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI
     LYHLYGAPIQ NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
     QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP