GP141_HUMAN
ID GP141_HUMAN Reviewed; 305 AA.
AC Q7Z602; A4D1X7; Q0VAR5; Q86SP3;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Probable G-protein coupled receptor 141;
DE AltName: Full=G-protein coupled receptor PGR13;
GN Name=GPR141; Synonyms=PGR13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT lacking close relatives.";
RL FEBS Lett. 554:381-388(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-219.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [5]
RP VARIANT HIS-72.
RX PubMed=25787250; DOI=10.1073/pnas.1503696112;
RA Cromer M.K., Choi M., Nelson-Williams C., Fonseca A.L., Kunstman J.W.,
RA Korah R.M., Overton J.D., Mane S., Kenney B., Malchoff C.D., Stalberg P.,
RA Akerstroem G., Westin G., Hellman P., Carling T., Bjoerklund P.,
RA Lifton R.P.;
RT "Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in
RT insulin-producing adenomas.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:4062-4067(2015).
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC Q7Z602; P07339: CTSD; NbExp=3; IntAct=EBI-21649723, EBI-2115097;
CC Q7Z602; G5E9A7: DMWD; NbExp=3; IntAct=EBI-21649723, EBI-10976677;
CC Q7Z602; P28799: GRN; NbExp=3; IntAct=EBI-21649723, EBI-747754;
CC Q7Z602; P04792: HSPB1; NbExp=3; IntAct=EBI-21649723, EBI-352682;
CC Q7Z602; P42858: HTT; NbExp=3; IntAct=EBI-21649723, EBI-466029;
CC Q7Z602; O60333-2: KIF1B; NbExp=3; IntAct=EBI-21649723, EBI-10975473;
CC Q7Z602; D3DTS7: PMP22; NbExp=3; IntAct=EBI-21649723, EBI-25882629;
CC Q7Z602; O60260-5: PRKN; NbExp=3; IntAct=EBI-21649723, EBI-21251460;
CC Q7Z602; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-21649723, EBI-396669;
CC Q7Z602; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-21649723, EBI-5235340;
CC Q7Z602; P02766: TTR; NbExp=3; IntAct=EBI-21649723, EBI-711909;
CC Q7Z602; O76024: WFS1; NbExp=3; IntAct=EBI-21649723, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY288420; AAP72129.1; -; mRNA.
DR EMBL; CH236951; EAL23980.1; -; Genomic_DNA.
DR EMBL; BC120951; AAI20952.1; -; mRNA.
DR EMBL; BC120952; AAI20953.1; -; mRNA.
DR EMBL; AY255538; AAO85050.1; -; mRNA.
DR CCDS; CCDS5451.1; -.
DR RefSeq; NP_001316922.1; NM_001329993.1.
DR RefSeq; NP_001316923.1; NM_001329994.1.
DR RefSeq; NP_861456.1; NM_181791.2.
DR RefSeq; XP_011513687.1; XM_011515385.2.
DR RefSeq; XP_011513688.1; XM_011515386.2.
DR RefSeq; XP_011513690.1; XM_011515388.2.
DR RefSeq; XP_011513691.1; XM_011515389.2.
DR RefSeq; XP_016867654.1; XM_017012165.1.
DR RefSeq; XP_016867655.1; XM_017012166.1.
DR AlphaFoldDB; Q7Z602; -.
DR SMR; Q7Z602; -.
DR BioGRID; 131689; 23.
DR IntAct; Q7Z602; 24.
DR STRING; 9606.ENSP00000390410; -.
DR ChEMBL; CHEMBL4523879; -.
DR GlyGen; Q7Z602; 2 sites.
DR iPTMnet; Q7Z602; -.
DR PhosphoSitePlus; Q7Z602; -.
DR BioMuta; GPR141; -.
DR DMDM; 62900364; -.
DR MassIVE; Q7Z602; -.
DR PaxDb; Q7Z602; -.
DR PeptideAtlas; Q7Z602; -.
DR PRIDE; Q7Z602; -.
DR Antibodypedia; 66618; 59 antibodies from 14 providers.
DR DNASU; 353345; -.
DR Ensembl; ENST00000334425.2; ENSP00000334540.1; ENSG00000187037.9.
DR Ensembl; ENST00000447769.1; ENSP00000390410.1; ENSG00000187037.9.
DR GeneID; 353345; -.
DR KEGG; hsa:353345; -.
DR MANE-Select; ENST00000334425.2; ENSP00000334540.1; NM_001381946.1; NP_001368875.1.
DR UCSC; uc003tfm.1; human.
DR CTD; 353345; -.
DR DisGeNET; 353345; -.
DR GeneCards; GPR141; -.
DR HGNC; HGNC:19997; GPR141.
DR HPA; ENSG00000187037; Tissue enriched (bone).
DR MIM; 609045; gene.
DR neXtProt; NX_Q7Z602; -.
DR OpenTargets; ENSG00000187037; -.
DR PharmGKB; PA134923895; -.
DR VEuPathDB; HostDB:ENSG00000187037; -.
DR eggNOG; ENOG502RXS2; Eukaryota.
DR GeneTree; ENSGT01030000234518; -.
DR HOGENOM; CLU_069285_0_0_1; -.
DR InParanoid; Q7Z602; -.
DR OMA; LWNCLLC; -.
DR OrthoDB; 1432969at2759; -.
DR PhylomeDB; Q7Z602; -.
DR TreeFam; TF333221; -.
DR PathwayCommons; Q7Z602; -.
DR SignaLink; Q7Z602; -.
DR BioGRID-ORCS; 353345; 7 hits in 1068 CRISPR screens.
DR ChiTaRS; GPR141; human.
DR GeneWiki; GPR141; -.
DR GenomeRNAi; 353345; -.
DR Pharos; Q7Z602; Tdark.
DR PRO; PR:Q7Z602; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q7Z602; protein.
DR Bgee; ENSG00000187037; Expressed in monocyte and 88 other tissues.
DR ExpressionAtlas; Q7Z602; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..305
FT /note="Probable G-protein coupled receptor 141"
FT /id="PRO_0000069618"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 72
FT /note="R -> H (in dbSNP:rs772202718)"
FT /evidence="ECO:0000269|PubMed:25787250"
FT /id="VAR_074185"
SQ SEQUENCE 305 AA; 35464 MW; CC078FF8AE34DF39 CRC64;
MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV TTMAVINLVV
VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY LTFLFYVVIL VTRYLIFFKC
KDKVEFYRKL HAVAASAGMW TLVIVIVVPL VVSRYGIHEE YNEEHCFKFH KELAYTYVKI
INYMIVIFVI AVAVILLVFQ VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP
YQFFRIYYLN VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN
CVLCR
