GP141_MOUSE
ID GP141_MOUSE Reviewed; 305 AA.
AC Q7TQP0; Q059N8; Q80UC5;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Probable G-protein coupled receptor 141;
DE AltName: Full=G-protein coupled receptor PGR13;
GN Name=Gpr141; Synonyms=Pgr13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT lacking close relatives.";
RL FEBS Lett. 554:381-388(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-304.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY288427; AAP72136.1; -; mRNA.
DR EMBL; BC125585; AAI25586.1; -; mRNA.
DR EMBL; BC125587; AAI25588.1; -; mRNA.
DR EMBL; AY255553; AAO85065.1; -; mRNA.
DR CCDS; CCDS26264.1; -.
DR RefSeq; NP_861419.3; NM_181754.4.
DR RefSeq; XP_006516766.1; XM_006516703.3.
DR RefSeq; XP_006516767.1; XM_006516704.3.
DR RefSeq; XP_006516768.1; XM_006516705.3.
DR RefSeq; XP_011242615.1; XM_011244313.2.
DR RefSeq; XP_011242616.1; XM_011244314.2.
DR RefSeq; XP_011242617.1; XM_011244315.2.
DR RefSeq; XP_011242618.1; XM_011244316.2.
DR AlphaFoldDB; Q7TQP0; -.
DR SMR; Q7TQP0; -.
DR STRING; 10090.ENSMUSP00000066921; -.
DR GlyGen; Q7TQP0; 2 sites.
DR PhosphoSitePlus; Q7TQP0; -.
DR PaxDb; Q7TQP0; -.
DR PRIDE; Q7TQP0; -.
DR Antibodypedia; 66618; 59 antibodies from 14 providers.
DR DNASU; 353346; -.
DR Ensembl; ENSMUST00000065335; ENSMUSP00000066921; ENSMUSG00000053101.
DR GeneID; 353346; -.
DR KEGG; mmu:353346; -.
DR UCSC; uc007ppl.1; mouse.
DR CTD; 353345; -.
DR MGI; MGI:2672983; Gpr141.
DR VEuPathDB; HostDB:ENSMUSG00000053101; -.
DR eggNOG; ENOG502RXS2; Eukaryota.
DR GeneTree; ENSGT01030000234518; -.
DR HOGENOM; CLU_069285_0_0_1; -.
DR InParanoid; Q7TQP0; -.
DR OMA; LWNCLLC; -.
DR OrthoDB; 1432969at2759; -.
DR PhylomeDB; Q7TQP0; -.
DR TreeFam; TF333221; -.
DR BioGRID-ORCS; 353346; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q7TQP0; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q7TQP0; protein.
DR Bgee; ENSMUSG00000053101; Expressed in granulocyte and 31 other tissues.
DR ExpressionAtlas; Q7TQP0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..305
FT /note="Probable G-protein coupled receptor 141"
FT /id="PRO_0000069619"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 305 AA; 35284 MW; 74C7EB210158D554 CRC64;
MDGYNTSENS SCDPILAHHL TSIYFIVLIG GLVGLISILF LLVKMNSRSV TTMAVINLVV
VHGVFLLTVP FRLAYLIKGT WTFGLPFCKF VSAMLHIHMY LTFLFYVVIL VIRYLIFFKR
RDKVEFYRKL HAVAASSAMW LLVIVIVVPL VVSQYGNSEE YNEQQCFRFH KELGHDSVRV
INYMIVIVVI AVALILLGFQ VFITLSMVRK FRHSLLSHQE FWAQLKNLFF IGIIIICFLP
YQFFRIYYLY VVAHSKSCKN KVAFYNEILL STTAISCCDL LLFVFGGSHW VKQKIVDMWN
CLLCH
