GP142_HUMAN
ID GP142_HUMAN Reviewed; 462 AA.
AC Q7Z601; A4CYJ8; Q86SL3;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable G-protein coupled receptor 142;
DE AltName: Full=G-protein coupled receptor PGR2;
GN Name=GPR142; Synonyms=PGR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT lacking close relatives.";
RL FEBS Lett. 554:381-388(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15845401; DOI=10.1016/j.bbrc.2005.03.174;
RA Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J.,
RA Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.;
RT "Molecular cloning and characterization of a novel Gq-coupled orphan
RT receptor GPRg1 exclusively expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 331:363-369(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-436, AND VARIANT ASN-132.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the central nervous
CC system, most abundantly in the ventrolateral region of caudate putamen,
CC the habenular nucleus, the zona incerta, and the medial mammillary
CC nucleus. {ECO:0000269|PubMed:15845401}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY288421; AAP72130.1; -; mRNA.
DR EMBL; AB196530; BAD97441.1; -; mRNA.
DR EMBL; AY255622; AAO85134.1; -; mRNA.
DR CCDS; CCDS11698.1; -.
DR RefSeq; NP_001318005.1; NM_001331076.1.
DR RefSeq; NP_001318006.1; NM_001331077.1.
DR RefSeq; NP_861455.1; NM_181790.1.
DR AlphaFoldDB; Q7Z601; -.
DR SMR; Q7Z601; -.
DR BioGRID; 131570; 2.
DR STRING; 9606.ENSP00000335158; -.
DR BindingDB; Q7Z601; -.
DR ChEMBL; CHEMBL2069161; -.
DR GuidetoPHARMACOLOGY; 132; -.
DR iPTMnet; Q7Z601; -.
DR PhosphoSitePlus; Q7Z601; -.
DR BioMuta; GPR142; -.
DR DMDM; 83288229; -.
DR PaxDb; Q7Z601; -.
DR PeptideAtlas; Q7Z601; -.
DR PRIDE; Q7Z601; -.
DR Antibodypedia; 51646; 181 antibodies from 29 providers.
DR DNASU; 350383; -.
DR Ensembl; ENST00000335666.4; ENSP00000335158.4; ENSG00000257008.7.
DR GeneID; 350383; -.
DR KEGG; hsa:350383; -.
DR UCSC; uc032fqt.2; human.
DR CTD; 350383; -.
DR DisGeNET; 350383; -.
DR GeneCards; GPR142; -.
DR HGNC; HGNC:20088; GPR142.
DR HPA; ENSG00000257008; Not detected.
DR MIM; 609046; gene.
DR neXtProt; NX_Q7Z601; -.
DR OpenTargets; ENSG00000257008; -.
DR PharmGKB; PA134891802; -.
DR VEuPathDB; HostDB:ENSG00000257008; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160948; -.
DR HOGENOM; CLU_009579_24_1_1; -.
DR InParanoid; Q7Z601; -.
DR OMA; LKWVHCF; -.
DR OrthoDB; 994073at2759; -.
DR PhylomeDB; Q7Z601; -.
DR TreeFam; TF334275; -.
DR PathwayCommons; Q7Z601; -.
DR BioGRID-ORCS; 350383; 11 hits in 1058 CRISPR screens.
DR GeneWiki; GPR142; -.
DR GenomeRNAi; 350383; -.
DR Pharos; Q7Z601; Tchem.
DR PRO; PR:Q7Z601; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q7Z601; protein.
DR Bgee; ENSG00000257008; Expressed in islet of Langerhans and 57 other tissues.
DR ExpressionAtlas; Q7Z601; baseline and differential.
DR GO; GO:0030054; C:cell junction; IDA:HPA.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..462
FT /note="Probable G-protein coupled receptor 142"
FT /id="PRO_0000069620"
FT TOPO_DOM 1..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..316
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..397
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..462
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 87..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 132
FT /note="H -> N (in dbSNP:rs2382647)"
FT /evidence="ECO:0000269|PubMed:12679517"
FT /id="VAR_061219"
SQ SEQUENCE 462 AA; 51106 MW; E9120B52372C75CA CRC64;
MSIMMLPMEQ KIQWVPTSLQ DITAVLGTEA YTEEDKSMVS HAQKSQHSCL SHSRWLRSPQ
VTGGSWDLRI RPSKDSSSFR QAQCLRKDPG ANNHLESQGV RGTAGDADRE LRGPSEKATA
GQPRVTLLPT PHVSGLSQEF ESHWPEIAER SPCVAGVIPV IYYSVLLGLG LPVSLLTAVA
LARLATRTRR PSYYYLLALT ASDIIIQVVI VFAGFLLQGA VLARQVPQAV VRTANILEFA
ANHASVWIAI LLTVDRYTAL CHPLHHRAAS SPGRTRRAIA AVLSAALLTG IPFYWWLDMW
RDTDSPRTLD EVLKWAHCLT VYFIPCGVFL VTNSAIIHRL RRRGRSGLQP RVGKSTAILL
GITTLFTLLW APRVFVMLYH MYVAPVHRDW RVHLALDVAN MVAMLHTAAN FGLYCFVSKT
FRATVRQVIH DAYLPCTLAS QPEGMAAKPV MEPPGLPTGA EV
