ID   GP142_MOUSE             Reviewed;         365 AA.
AC   Q7TQN9;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Probable G-protein coupled receptor 142;
GN   Name=Gpr142;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7;
RA   Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C.,
RA   Schioeth H.B.;
RT   "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors
RT   lacking close relatives.";
RL   FEBS Lett. 554:381-388(2003).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY288428; AAP72137.1; -; mRNA.
DR   CCDS; CCDS25611.1; -.
DR   RefSeq; NP_861414.1; NM_181749.1.
DR   AlphaFoldDB; Q7TQN9; -.
DR   SMR; Q7TQN9; -.
DR   STRING; 10090.ENSMUSP00000102194; -.
DR   BindingDB; Q7TQN9; -.
DR   ChEMBL; CHEMBL2069162; -.
DR   GlyGen; Q7TQN9; 1 site.
DR   PhosphoSitePlus; Q7TQN9; -.
DR   PaxDb; Q7TQN9; -.
DR   PRIDE; Q7TQN9; -.
DR   ProteomicsDB; 271258; -.
DR   Antibodypedia; 51646; 181 antibodies from 29 providers.
DR   DNASU; 217302; -.
DR   Ensembl; ENSMUST00000045319; ENSMUSP00000045029; ENSMUSG00000034677.
DR   GeneID; 217302; -.
DR   KEGG; mmu:217302; -.
DR   UCSC; uc007mfu.1; mouse.
DR   CTD; 350383; -.
DR   MGI; MGI:2668437; Gpr142.
DR   VEuPathDB; HostDB:ENSMUSG00000034677; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000160948; -.
DR   InParanoid; Q7TQN9; -.
DR   PhylomeDB; Q7TQN9; -.
DR   BioGRID-ORCS; 217302; 3 hits in 72 CRISPR screens.
DR   PRO; PR:Q7TQN9; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q7TQN9; protein.
DR   Bgee; ENSMUSG00000034677; Expressed in islet of Langerhans and 28 other tissues.
DR   ExpressionAtlas; Q7TQN9; baseline and differential.
DR   GO; GO:0030054; C:cell junction; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IC:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..365
FT                   /note="Probable G-protein coupled receptor 142"
FT                   /id="PRO_0000069621"
FT   TOPO_DOM        1..66
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..140
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..185
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..224
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..365
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   365 AA;  40758 MW;  ACA8649245CDAE47 CRC64;
     MHLNSNPNSY ICDAYQHADL LWSLSPHVLT KAVQPQVTLL PTVNGSNPRY DGVDGHWPES
     PERSPCVAGI IPVIYYSVLL SLGLPVALAR LAARTRKPSY HYLLALTASD IVTQVIIVFV
     GFLLQGAVLA RQVPQAVVRT ANILEFAANH ASVWIAVLFT VDRYNALCRP LRHRATSSPG
     RTHRAIAAVI GVTLLTGIPF YWWLDVWRDA DPPSTMDKLL KWAHCLIVYF IPCNVFLVTN
     SAIILRLRKR GQRGLRPLVS KSTAILLGVT SLFALLWAPR IIVMLYHLYV APVHRDWRVH
     LALDIANMLA MLNTEVNFGL YCFISKTFRA TVRQVICDVH MACALKSQPK QTVVELMLKS
     VGTEL