GP146_HUMAN
ID GP146_HUMAN Reviewed; 333 AA.
AC Q96CH1; Q86SP5;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable G-protein coupled receptor 146;
DE AltName: Full=G-protein coupled receptor PGR8;
GN Name=GPR146; Synonyms=PGR8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-210.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC014241; AAH14241.1; -; mRNA.
DR EMBL; AY255535; AAO85047.1; -; mRNA.
DR CCDS; CCDS5321.1; -.
DR RefSeq; NP_001290402.1; NM_001303473.1.
DR RefSeq; NP_001290403.1; NM_001303474.1.
DR RefSeq; NP_612454.1; NM_138445.3.
DR RefSeq; XP_005249670.1; XM_005249613.2.
DR RefSeq; XP_006715706.1; XM_006715643.2.
DR AlphaFoldDB; Q96CH1; -.
DR SMR; Q96CH1; -.
DR BioGRID; 125426; 2.
DR IntAct; Q96CH1; 2.
DR MINT; Q96CH1; -.
DR STRING; 9606.ENSP00000380283; -.
DR ChEMBL; CHEMBL4523904; -.
DR GlyGen; Q96CH1; 1 site.
DR iPTMnet; Q96CH1; -.
DR PhosphoSitePlus; Q96CH1; -.
DR BioMuta; GPR146; -.
DR DMDM; 67461068; -.
DR PaxDb; Q96CH1; -.
DR PeptideAtlas; Q96CH1; -.
DR PRIDE; Q96CH1; -.
DR Antibodypedia; 10880; 287 antibodies from 29 providers.
DR DNASU; 115330; -.
DR Ensembl; ENST00000397095.2; ENSP00000380283.1; ENSG00000164849.10.
DR Ensembl; ENST00000444847.2; ENSP00000410743.2; ENSG00000164849.10.
DR GeneID; 115330; -.
DR KEGG; hsa:115330; -.
DR MANE-Select; ENST00000444847.2; ENSP00000410743.2; NM_001303473.2; NP_001290402.1.
DR UCSC; uc003sjx.5; human.
DR CTD; 115330; -.
DR DisGeNET; 115330; -.
DR GeneCards; GPR146; -.
DR HGNC; HGNC:21718; GPR146.
DR HPA; ENSG00000164849; Low tissue specificity.
DR neXtProt; NX_Q96CH1; -.
DR OpenTargets; ENSG00000164849; -.
DR PharmGKB; PA134958088; -.
DR VEuPathDB; HostDB:ENSG00000164849; -.
DR eggNOG; ENOG502QPPG; Eukaryota.
DR GeneTree; ENSGT01030000234518; -.
DR InParanoid; Q96CH1; -.
DR OMA; YICSHVA; -.
DR OrthoDB; 662615at2759; -.
DR PhylomeDB; Q96CH1; -.
DR TreeFam; TF333506; -.
DR PathwayCommons; Q96CH1; -.
DR SignaLink; Q96CH1; -.
DR BioGRID-ORCS; 115330; 9 hits in 1072 CRISPR screens.
DR ChiTaRS; GPR146; human.
DR GeneWiki; GPR146; -.
DR GenomeRNAi; 115330; -.
DR Pharos; Q96CH1; Tbio.
DR PRO; PR:Q96CH1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96CH1; protein.
DR Bgee; ENSG00000164849; Expressed in subcutaneous adipose tissue and 140 other tissues.
DR ExpressionAtlas; Q96CH1; baseline and differential.
DR Genevisible; Q96CH1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR037487; GPR146.
DR PANTHER; PTHR24226:SF3; PTHR24226:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Probable G-protein coupled receptor 146"
FT /id="PRO_0000069622"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 333 AA; 36580 MW; BB8D6505A6C2D9F4 CRC64;
MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL ANLHSKASMT
MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE VHVALQIPFN VSSLVAMYST
ALLSLDHYIE RALPRTYMAS VYNTRHVCGF VWGGALLTSF SSLLFYICSH VSTRALECAK
MQNAEAADAT LVFIGYVVPA LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC
TQFGLWTPHY LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN
QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA
