GP146_MOUSE
ID GP146_MOUSE Reviewed; 333 AA.
AC Q99LE2; Q3U3K8; Q3U421; Q8BHR6; Q8BHU4;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Probable G-protein coupled receptor 146;
GN Name=Gpr146;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone, Corpora quadrigemina, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AK046512; BAC32762.1; -; mRNA.
DR EMBL; AK087100; BAC39803.1; -; mRNA.
DR EMBL; AK089232; BAC40804.1; -; mRNA.
DR EMBL; AK154478; BAE32614.1; -; mRNA.
DR EMBL; AK137454; BAE23357.1; -; mRNA.
DR EMBL; AK154708; BAE32777.1; -; mRNA.
DR EMBL; AK155876; BAE33478.1; -; mRNA.
DR EMBL; CH466529; EDL19154.1; -; Genomic_DNA.
DR EMBL; BC003323; AAH03323.1; -; mRNA.
DR CCDS; CCDS19809.1; -.
DR RefSeq; NP_001033792.1; NM_001038703.2.
DR RefSeq; NP_084534.2; NM_030258.4.
DR RefSeq; XP_006504837.1; XM_006504774.2.
DR AlphaFoldDB; Q99LE2; -.
DR SMR; Q99LE2; -.
DR STRING; 10090.ENSMUSP00000098083; -.
DR GlyGen; Q99LE2; 1 site.
DR PhosphoSitePlus; Q99LE2; -.
DR PaxDb; Q99LE2; -.
DR PRIDE; Q99LE2; -.
DR ProteomicsDB; 267649; -.
DR Antibodypedia; 10880; 287 antibodies from 29 providers.
DR DNASU; 80290; -.
DR Ensembl; ENSMUST00000051293; ENSMUSP00000049707; ENSMUSG00000044197.
DR Ensembl; ENSMUST00000100514; ENSMUSP00000098083; ENSMUSG00000044197.
DR GeneID; 80290; -.
DR KEGG; mmu:80290; -.
DR UCSC; uc009agm.2; mouse.
DR CTD; 115330; -.
DR MGI; MGI:1933113; Gpr146.
DR VEuPathDB; HostDB:ENSMUSG00000044197; -.
DR eggNOG; ENOG502QPPG; Eukaryota.
DR GeneTree; ENSGT01030000234518; -.
DR HOGENOM; CLU_065932_0_0_1; -.
DR InParanoid; Q99LE2; -.
DR OMA; YICSHVA; -.
DR OrthoDB; 988777at2759; -.
DR PhylomeDB; Q99LE2; -.
DR TreeFam; TF333506; -.
DR BioGRID-ORCS; 80290; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Gpr146; mouse.
DR PRO; PR:Q99LE2; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q99LE2; protein.
DR Bgee; ENSMUSG00000044197; Expressed in interventricular septum and 186 other tissues.
DR ExpressionAtlas; Q99LE2; baseline and differential.
DR Genevisible; Q99LE2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR037487; GPR146.
DR PANTHER; PTHR24226:SF3; PTHR24226:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Probable G-protein coupled receptor 146"
FT /id="PRO_0000069623"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 192
FT /note="L -> V (in Ref. 1; BAC40804/BAE32614 and 3;
FT AAH03323)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="A -> P (in Ref. 1; BAC39803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 36572 MW; C51690838AB42988 CRC64;
MWSCGPLNST AWAEEPLCRN LRLGLWVLSL LYLGAGVPVS LGYNALLVLA NLASKNTMTM
PDVYFVNMAV AGLVLTALAP AYLLGPAHSR WALWSLSSEA HVTLLILFNV ASLVTMYSTA
LLSLDYYIER ALPRTYMASV YNTRHVCGFV WGGAVLTSFS SLLFYICSHV SSRIAECARM
QNTEAADAIL VLIGYVVPGL AVLYALALIS RIGKEDTPLD QDTSRLDPSV HRLLVATVCT
QFGLWTPYYL SLGHTVLTSR GRTVEGHYLG ILQVAKDLAK FLAFSSSSVT PLLYRYINKA
FPGKLRRLMK KMHCGRRHCS PDPSGIQQVM AQA
