ID   GP146_XENLA             Reviewed;         333 AA.
AC   Q6P7G9;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable G-protein coupled receptor 146;
GN   Name=gpr146;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; BC061674; AAH61674.1; -; mRNA.
DR   RefSeq; NP_001083569.1; NM_001090100.1.
DR   AlphaFoldDB; Q6P7G9; -.
DR   SMR; Q6P7G9; -.
DR   DNASU; 398996; -.
DR   GeneID; 398996; -.
DR   KEGG; xla:398996; -.
DR   CTD; 398996; -.
DR   Xenbase; XB-GENE-956310; gpr146.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 398996; Expressed in lung and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR037487; GPR146.
DR   PANTHER; PTHR24226:SF3; PTHR24226:SF3; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Probable G-protein coupled receptor 146"
FT                   /id="PRO_0000069624"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..102
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   333 AA;  38008 MW;  EB72DC50EC8EE815 CRC64;
     MWSCEDLNYT NSGEEQYLCN EFHLFLFIFS VLYLIICFPV GLCYNVQLVL VNLYNKATMT
     MPDVYFVNMA IAGLIINAVA PVYLFGPAYT KWSLWSFGNE VYITLLILFN VSSLVIMYST
     TLLSLDYYIE CALPRTYMSS VYNTKHVCGF IWGGAVLTSF SSLLFYICNH VSTKIIECSK
     MQNREAADAI MVLIGYVVPI IAVIYALVLI LQIRKEATPL DQESGRLDPS VHRLLIATVC
     TQFILWTPYY VTLLVNTFMD ARVKSSNTFY IRIFQFTEGL SNFLAFSSSF VLPLIHRHIN
     KNFSGKLQRL LKRLHCGSQG CTHEHTVVQQ VMT