GP148_HUMAN
ID GP148_HUMAN Reviewed; 347 AA.
AC Q8TDV2; Q2M369; Q86SP7; Q86U87;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable G-protein coupled receptor 148;
DE AltName: Full=Brain and testis restricted GPCR;
DE AltName: Full=G-protein coupled receptor PGR6;
GN Name=GPR148; Synonyms=BTR, PGR6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PRO-317.
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT PRO-317.
RX PubMed=15688318;
RA Parmigiani R.B., Magalhaes G.S., Galante P.A.F., Manzini C.V.B.,
RA Camargo A.A., Malnic B.;
RT "A novel human G protein-coupled receptor is over-expressed in prostate
RT cancer.";
RL Genet. Mol. Res. 3:521-531(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PRO-317.
RC TISSUE=Brain;
RA Bonner T.I., Nagle J.W., Kauffman D.;
RT "Complete coding sequence of GPR148.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-317.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-279.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC Q8TDV2; Q2M3D2: EXOC3L2; NbExp=3; IntAct=EBI-17294222, EBI-14890134;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expression restricted to nervous system and testis.
CC Is also detected in several tumors types, most notably prostate cancer.
CC {ECO:0000269|PubMed:15688318}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB083589; BAB89302.1; -; Genomic_DNA.
DR EMBL; AY280965; AAP34196.1; -; mRNA.
DR EMBL; AY569570; AAS76892.1; -; mRNA.
DR EMBL; AC140481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC105013; AAI05014.1; -; mRNA.
DR EMBL; BC105041; AAI05042.1; -; mRNA.
DR EMBL; AY255532; AAO85044.1; -; mRNA.
DR CCDS; CCDS2163.1; -.
DR RefSeq; NP_997247.2; NM_207364.2.
DR AlphaFoldDB; Q8TDV2; -.
DR SMR; Q8TDV2; -.
DR BioGRID; 131308; 18.
DR IntAct; Q8TDV2; 1.
DR STRING; 9606.ENSP00000308908; -.
DR ChEMBL; CHEMBL4523901; -.
DR GlyGen; Q8TDV2; 1 site.
DR iPTMnet; Q8TDV2; -.
DR PhosphoSitePlus; Q8TDV2; -.
DR BioMuta; GPR148; -.
DR DMDM; 311033389; -.
DR PaxDb; Q8TDV2; -.
DR PeptideAtlas; Q8TDV2; -.
DR PRIDE; Q8TDV2; -.
DR Antibodypedia; 18608; 57 antibodies from 19 providers.
DR DNASU; 344561; -.
DR Ensembl; ENST00000309926.4; ENSP00000308908.4; ENSG00000173302.5.
DR GeneID; 344561; -.
DR KEGG; hsa:344561; -.
DR MANE-Select; ENST00000309926.4; ENSP00000308908.4; NM_207364.2; NP_997247.2.
DR UCSC; uc002trv.2; human.
DR CTD; 344561; -.
DR GeneCards; GPR148; -.
DR HGNC; HGNC:23623; GPR148.
DR HPA; ENSG00000173302; Not detected.
DR neXtProt; NX_Q8TDV2; -.
DR OpenTargets; ENSG00000173302; -.
DR PharmGKB; PA134942667; -.
DR VEuPathDB; HostDB:ENSG00000173302; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01040000240430; -.
DR HOGENOM; CLU_067256_0_0_1; -.
DR InParanoid; Q8TDV2; -.
DR OMA; TYAAVRW; -.
DR OrthoDB; 1419205at2759; -.
DR PhylomeDB; Q8TDV2; -.
DR TreeFam; TF333617; -.
DR PathwayCommons; Q8TDV2; -.
DR BioGRID-ORCS; 344561; 9 hits in 1059 CRISPR screens.
DR GeneWiki; GPR148; -.
DR GenomeRNAi; 344561; -.
DR Pharos; Q8TDV2; Tbio.
DR PRO; PR:Q8TDV2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8TDV2; protein.
DR Bgee; ENSG00000173302; Expressed in islet of Langerhans and 14 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..347
FT /note="Probable G-protein coupled receptor 148"
FT /id="PRO_0000069625"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..130
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 317
FT /note="T -> P (in dbSNP:rs272128)"
FT /evidence="ECO:0000269|PubMed:12044878,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15688318,
FT ECO:0000269|Ref.3"
FT /id="VAR_049403"
FT CONFLICT 27..62
FT /note="CMPQAASNTSLGLGDLRVPSSMLYWLFLPSSLLAAA -> SS (in Ref.
FT 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="A -> D (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="S -> F (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="A -> G (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="R -> G (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="A -> P (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="L -> F (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="A -> V (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="L -> F (in Ref. 2; AAP34196)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 38288 MW; EA2ECACE2BD542A8 CRC64;
MGDELAPCPV GTTAWPALIQ LISKTPCMPQ AASNTSLGLG DLRVPSSMLY WLFLPSSLLA
AATLAVSPLL LVTILRNQRL RQEPHYLLPA NILLSDLAYI LLHMLISSSS LGGWELGRMA
CGILTDAVFA ACTSTILSFT AIVLHTYLAV IHPLRYLSFM SHGAAWKAVA LIWLVACCFP
TFLIWLSKWQ DAQLEEQGAS YILPPSMGTQ PGCGLLVIVT YTSILCVLFL CTALIANCFW
RIYAEAKTSG IWGQGYSRAR GTLLIHSVLI TLYVSTGVVF SLDMVLTRYH HIDSGTHTWL
LAANSEVLMM LPRAMLTYLY LLRYRQLLGM VRGHLPSRRH QAIFTIS
