GP149_CHICK
ID GP149_CHICK Reviewed; 723 AA.
AC Q9DDD1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Probable G-protein coupled receptor 149;
DE AltName: Full=G-protein coupled receptor R35;
GN Name=GPR149; Synonyms=R35;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Spinal ganglion;
RX PubMed=11161467; DOI=10.1006/mcne.2000.0912;
RA Friedel R.H., Stubbusch J., Barde Y.-A., Schnuerch H.;
RT "A novel 7-transmembrane receptor expressed in nerve growth factor-
RT dependent sensory neurons.";
RL Mol. Cell. Neurosci. 17:31-40(2001).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Specific expression in peripheral nervous system,
CC including nerve growth factor-dependent sensory and sympathetic
CC neurons, as well as enteric neurons.
CC -!- DEVELOPMENTAL STAGE: Mostly restricted to cells of the nervous system.
CC Expressed in NGF-dependent neurons of the PNS, but also found in
CC subpopulations of CNS neurons, like spinal cord motoneurons, retinal
CC ganglia cells and EGL cells of the cerebellum.
CC {ECO:0000269|PubMed:11161467}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ293971; CAC21497.1; -; mRNA.
DR RefSeq; NP_989993.1; NM_204662.1.
DR AlphaFoldDB; Q9DDD1; -.
DR STRING; 9031.ENSGALP00000016812; -.
DR PaxDb; Q9DDD1; -.
DR PRIDE; Q9DDD1; -.
DR Ensembl; ENSGALT00000016831; ENSGALP00000016812; ENSGALG00000010337.
DR GeneID; 395382; -.
DR KEGG; gga:395382; -.
DR CTD; 344758; -.
DR VEuPathDB; HostDB:geneid_395382; -.
DR eggNOG; KOG0331; Eukaryota.
DR GeneTree; ENSGT00390000003715; -.
DR HOGENOM; CLU_021967_0_0_1; -.
DR InParanoid; Q9DDD1; -.
DR OMA; NYECETT; -.
DR OrthoDB; 352121at2759; -.
DR PhylomeDB; Q9DDD1; -.
DR TreeFam; TF331679; -.
DR PRO; PR:Q9DDD1; -.
DR Proteomes; UP000000539; Chromosome 9.
DR Bgee; ENSGALG00000010337; Expressed in spermatocyte and 5 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..723
FT /note="Probable G-protein coupled receptor 149"
FT /id="PRO_0000069629"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..723
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 451..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 103..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 723 AA; 79664 MW; 8BF2D2444A8A6373 CRC64;
MSVMPSNLSL NGTSFFAENH SIMDKPNEQR TLNVFLFCST FIIAFTVLLG SIYSLVSLLK
LQNKSTISMI VTSLSIDDLI SIVPVIIFML TQWSSDALPQ PLCTTSALIY LFQGISSNLK
GSLIVSYNFY SINKTETMNC SASKRRVSMV WAILSIWIVS LLICILPLCG WGKYIPTTWG
CFTDHASSYI LFLFIVYSLC FCLLTVLSVP LTYQLLCSDE QQLLHVNYQE ISRGYITPGT
PAGCSTATPC LSPVDPVDKT LKHFQNACLS SKAVFRKGVA ESSGLEPRCM NNAKSRSFTV
GFAQKRFSLI LALTKVILWL PMMIQMVVQH ITGYQSFSFE TLSFLLTLLA ATVTPVFVLS
EHWIHLPCGC IINCRRNSYA VSSEELKTKH RGFEFNLSFQ HGYGIYRISP ESHHHDGDGK
STSCHNLLVC EKPYEPPRGG GGGAALAELS TTDSARPGPA GLSATDSARP GPAGFSTTDS
ARPSAAGVRG EAASGLGRTV EGPERRLSHE EGHKPELTDW EWCRSKSERT PRQRSGGALA
IPLCAFQGTV SLQAPTGKTL SLSTYEVSTE GQKITPTSKK IEVYRSKSVG HDPNPEECPN
TFADTSVKIH LEVLEICDNE EALDTVSIIS NISQSSTQVR SPSLRYSRKE NRFVSCDLGE
TASYSLFIPS NNPDSDINIT IPDTVEAHRQ NSKKQHMERG GYQEEIQMLN KAYRKREEDG
NSN
