GP149_HUMAN
ID GP149_HUMAN Reviewed; 731 AA.
AC Q86SP6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Probable G-protein coupled receptor 149;
DE AltName: Full=G-protein coupled receptor PGR10;
GN Name=GPR149; Synonyms=PGR10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 156-589.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC092946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY255534; AAO85046.1; -; mRNA.
DR CCDS; CCDS43162.1; -.
DR RefSeq; NP_001033794.1; NM_001038705.1.
DR AlphaFoldDB; Q86SP6; -.
DR BioGRID; 131320; 1.
DR STRING; 9606.ENSP00000374390; -.
DR ChEMBL; CHEMBL4523883; -.
DR GlyGen; Q86SP6; 3 sites.
DR iPTMnet; Q86SP6; -.
DR PhosphoSitePlus; Q86SP6; -.
DR BioMuta; GPR149; -.
DR DMDM; 84029267; -.
DR MassIVE; Q86SP6; -.
DR PaxDb; Q86SP6; -.
DR PeptideAtlas; Q86SP6; -.
DR PRIDE; Q86SP6; -.
DR Antibodypedia; 9095; 212 antibodies from 30 providers.
DR DNASU; 344758; -.
DR Ensembl; ENST00000389740.3; ENSP00000374390.2; ENSG00000174948.6.
DR GeneID; 344758; -.
DR KEGG; hsa:344758; -.
DR MANE-Select; ENST00000389740.3; ENSP00000374390.2; NM_001038705.3; NP_001033794.1.
DR UCSC; uc003faa.3; human.
DR CTD; 344758; -.
DR DisGeNET; 344758; -.
DR GeneCards; GPR149; -.
DR HGNC; HGNC:23627; GPR149.
DR HPA; ENSG00000174948; Tissue enriched (brain).
DR neXtProt; NX_Q86SP6; -.
DR OpenTargets; ENSG00000174948; -.
DR PharmGKB; PA134981369; -.
DR VEuPathDB; HostDB:ENSG00000174948; -.
DR eggNOG; KOG0331; Eukaryota.
DR GeneTree; ENSGT00390000003715; -.
DR HOGENOM; CLU_021967_0_0_1; -.
DR InParanoid; Q86SP6; -.
DR OMA; NYECETT; -.
DR OrthoDB; 352121at2759; -.
DR PhylomeDB; Q86SP6; -.
DR TreeFam; TF331679; -.
DR PathwayCommons; Q86SP6; -.
DR SignaLink; Q86SP6; -.
DR BioGRID-ORCS; 344758; 7 hits in 1060 CRISPR screens.
DR GenomeRNAi; 344758; -.
DR Pharos; Q86SP6; Tbio.
DR PRO; PR:Q86SP6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q86SP6; protein.
DR Bgee; ENSG00000174948; Expressed in nucleus accumbens and 17 other tissues.
DR ExpressionAtlas; Q86SP6; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0001547; P:antral ovarian follicle growth; IEA:Ensembl.
DR GO; GO:0060280; P:negative regulation of ovulation; IEA:Ensembl.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0001546; P:preantral ovarian follicle growth; IEA:Ensembl.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..731
FT /note="Probable G-protein coupled receptor 149"
FT /id="PRO_0000069626"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..342
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..731
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 234..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 731 AA; 80984 MW; 57A43042CB958A05 CRC64;
MSLFLSNLST NDSSLWKENH NSTDLLNPPG TLNIYLFCLT CLMTFAALVG SIYSLISLLK
MQNRTVVSML VASWSVDDLM SVLSVTIFMF LQWPNEVPGY FQFLCTTSAL MYLCQGLSSN
LKATLLVSYN FYTMHRGVGS QTASRRSGQV LGVVLTVWAA SLLLSALPLC GWGAFVRTPW
GCLVDCSSSY VLFLSIVYAL AFGLLVGLSV PLTHRLLCSE EPPRLHSNYQ EISRGASIPG
TPPTAGRVVS LSPEDAPGPS LRRSGGCSPS SDTVFGPGAP AAAGAEACRR ENRGTLYGTR
SFTVSVAQKR FALILALTKV VLWLPMMMHM VVQNVVGFQS LPLETFSFLL TLLATTVTPV
FVLSKRWTHL PCGCIINCRQ NAYAVASDGK KIKRKGFEFN LSFQKSYGIY KIAHEDYYDD
DENSIFYHNL MNSECETTKD PQRDNRNIFN AIKVEISTTP SLDSSTQRGI NKCTNTDITE
AKQDSNNKKD AFSDKTGGDI NYEETTFSEG PERRLSHEES QKPDLSDWEW CRSKSERTPR
QRSGYALAIP LCAFQGTVSL HAPTGKTLSL STYEVSAEGQ KITPASKKIE VYRSKSVGHE
PNSEDSSSTF VDTSVKIHLE VLEICDNEEA LDTVSIISNI SQSSTQVRSP SLRYSRKENR
FVSCDLGETA SYSLFLPTSN PDGDINISIP DTVEAHRQNS KRQHQERDGY QEEIQLLNKA
YRKREEESKG S
