GP149_MOUSE
ID GP149_MOUSE Reviewed; 732 AA.
AC Q3UVY1; Q3TMB1; Q80T52; Q8BXA3; Q8BZC0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Probable G-protein coupled receptor 149;
DE AltName: Full=G-protein coupled receptor PGR10;
GN Name=Gpr149; Synonyms=Pgr10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Diencephalon, Head, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 205-327.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
RL Nat. Biotechnol. 23:94-101(2005).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC33315.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK035931; BAC29247.1; -; mRNA.
DR EMBL; AK048373; BAC33315.1; ALT_INIT; mRNA.
DR EMBL; AK136826; BAE23138.1; -; mRNA.
DR EMBL; AK166029; BAE38531.1; -; mRNA.
DR EMBL; AY255591; AAO85103.1; -; mRNA.
DR CCDS; CCDS17380.1; -.
DR RefSeq; NP_796320.2; NM_177346.4.
DR AlphaFoldDB; Q3UVY1; -.
DR SMR; Q3UVY1; -.
DR STRING; 10090.ENSMUSP00000060893; -.
DR GlyGen; Q3UVY1; 1 site.
DR iPTMnet; Q3UVY1; -.
DR PhosphoSitePlus; Q3UVY1; -.
DR PaxDb; Q3UVY1; -.
DR PRIDE; Q3UVY1; -.
DR ProteomicsDB; 267650; -.
DR Antibodypedia; 9095; 212 antibodies from 30 providers.
DR DNASU; 229357; -.
DR Ensembl; ENSMUST00000058535; ENSMUSP00000060893; ENSMUSG00000043441.
DR GeneID; 229357; -.
DR KEGG; mmu:229357; -.
DR UCSC; uc008pjo.1; mouse.
DR CTD; 344758; -.
DR MGI; MGI:2443628; Gpr149.
DR VEuPathDB; HostDB:ENSMUSG00000043441; -.
DR eggNOG; KOG0331; Eukaryota.
DR GeneTree; ENSGT00390000003715; -.
DR HOGENOM; CLU_021967_0_0_1; -.
DR InParanoid; Q3UVY1; -.
DR OMA; NYECETT; -.
DR OrthoDB; 352121at2759; -.
DR PhylomeDB; Q3UVY1; -.
DR TreeFam; TF331679; -.
DR BioGRID-ORCS; 229357; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q3UVY1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q3UVY1; protein.
DR Bgee; ENSMUSG00000043441; Expressed in lumbar dorsal root ganglion and 36 other tissues.
DR Genevisible; Q3UVY1; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0001547; P:antral ovarian follicle growth; IMP:MGI.
DR GO; GO:0060280; P:negative regulation of ovulation; IMP:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0001546; P:preantral ovarian follicle growth; IMP:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..732
FT /note="Probable G-protein coupled receptor 149"
FT /id="PRO_0000069627"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..732
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 281..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 239
FT /note="T -> S (in Ref. 1; BAC33315)"
FT /evidence="ECO:0000305"
FT CONFLICT 366
FT /note="K -> E (in Ref. 1; BAE38531)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="W -> G (in Ref. 1; BAC33315)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 732 AA; 80520 MW; C5E762A8F3C2C98B CRC64;
MSFFLSNLTN DSNLWKASHN STETDLMNSP ATLTLSLFCL ICIMTLAALV GSIFSLVSLL
TMQYRTVLSI LVTSWSVDDL LSVLSVAIFM VLQWPKEAQG YFQSLCTTSA LLYMCQGLSS
NLKATLIVCY NFYTMNRTVE SQSSSWRLGQ VLGVTLTVWA VSLLLASLPL CGWGVFVRTP
WGCLTDCSSP YVLLLFAVYA SAFGLLAVLS VPLTHQLLCS EEPLRLHANY QEISRGASTP
GTPAAAGRVL CLPPEDVEIP ALRCTGGCSP SSDVVFAPGQ PAASGAGAGR RENPGTPQGT
NSFPLSLAQK RFSLILALTK VILWLPMMIH MVVKHVVGFQ SLPVDMLSFL LSLLASSVTP
VFVLSKRWAH LPCGCIINCQ PDTYSVAFDG KKSKRKGFEF NLSFQQSYGL YKIPHADCYD
DDENSISYHN PKNYECEATK EPWGDNRSVF NTITVEISTT PPLDSATLTG VHKCTNTDIP
ESKQAMKEEK GAFSVKTESD INYGETTSFE GPERRLSHEE NQKPDLSDWE WCRSKSERTP
RQRSGGGLAI PICAFQGTVS LQAPTGKTLS LSTYEVSAEG QKITPASKKI EVYRSKSVGH
EPNSEESPST FADTSVKIHL EVLEICDNDE ALDTVSIISN ISQSSTKVRS PSLRYSRKEN
RFVSCDLGET ASYSLFLPTS DPDGDINISI PDTVEAHRQN SRRQHEERDG YQEEIQLLNK
AYRKREAESK GD
