GP149_RAT
ID GP149_RAT Reviewed; 730 AA.
AC Q924Y8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable G-protein coupled receptor 149;
DE AltName: Full=Induced early in differentiating astrocytes gene protein;
GN Name=Gpr149; Synonyms=Ieda;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP ALTERNATIVE SPLICING.
RX PubMed=12065666; DOI=10.1046/j.1471-4159.2002.00847.x;
RA De Smet C., Nishimori H., Furnari F.B., Boegler O., Huang H.-J.S.,
RA Cavenee W.K.;
RT "A novel seven transmembrane receptor induced during the early steps of
RT astrocyte differentiation identified by differential expression.";
RL J. Neurochem. 81:575-588(2002).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced.;
CC Name=1; Synonyms=Ieda-L;
CC IsoId=Q924Y8-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed exclusively in brain and testis.
CC {ECO:0000269|PubMed:12065666}.
CC -!- DEVELOPMENTAL STAGE: Appeared in the brain of 16 days-old embryos and
CC was maintained during the subsequent developmental stages.
CC {ECO:0000269|PubMed:12065666}.
CC -!- INDUCTION: Expression increased during the early steps of astrocyte
CC differentiation.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY030276; AAK51132.1; -; mRNA.
DR RefSeq; NP_620246.1; NM_138891.1. [Q924Y8-1]
DR RefSeq; XP_017446091.1; XM_017590602.1. [Q924Y8-1]
DR AlphaFoldDB; Q924Y8; -.
DR SMR; Q924Y8; -.
DR STRING; 10116.ENSRNOP00000019929; -.
DR GlyGen; Q924Y8; 3 sites.
DR PhosphoSitePlus; Q924Y8; -.
DR PaxDb; Q924Y8; -.
DR Ensembl; ENSRNOT00000019929; ENSRNOP00000019929; ENSRNOG00000014793. [Q924Y8-1]
DR GeneID; 192251; -.
DR KEGG; rno:192251; -.
DR UCSC; RGD:619890; rat. [Q924Y8-1]
DR CTD; 344758; -.
DR RGD; 619890; Gpr149.
DR eggNOG; KOG0331; Eukaryota.
DR GeneTree; ENSGT00390000003715; -.
DR HOGENOM; CLU_021967_0_0_1; -.
DR InParanoid; Q924Y8; -.
DR OMA; NYECETT; -.
DR OrthoDB; 352121at2759; -.
DR PhylomeDB; Q924Y8; -.
DR TreeFam; TF331679; -.
DR PRO; PR:Q924Y8; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000014793; Expressed in colon and 5 other tissues.
DR Genevisible; Q924Y8; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0001547; P:antral ovarian follicle growth; ISO:RGD.
DR GO; GO:0060280; P:negative regulation of ovulation; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0001546; P:preantral ovarian follicle growth; ISO:RGD.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..730
FT /note="Probable G-protein coupled receptor 149"
FT /id="PRO_0000069628"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..340
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..730
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 730 AA; 80524 MW; F15AA7C80C0EAB86 CRC64;
MSFFLSNLTN DSRLWKVSHN STDLMNSPET LTLSLFCLIC LMTLVALVGS IFSLVSLLTM
QYRTVVSMLV TSWSVDDLLS VLSVAIFMVL QWPREAPGYF QSLCTTSALL YMCQGLSSNL
KATLIVFYNF YTMHRTVVSQ SSSWRSGQVL GVALTVWAVS LLLASLPLCG WGVFVRTPWG
CLTDCSSPYV LLLFAVYASA FGLLAVLSVP LTHQLLCSEE PPRLHANYQE ISRGASTPGT
PAAGGRVLCL LPEDVEIPAL PGTGSSLSSD MVFAPGQPAA SSAGAGKREN LWTPRGSSSF
PVSLAQKRFA LILALTKVIL WLPMMIHMVV KHVVGFQSLP VDMLSFLLTL LASTVTPVFV
LSKRWAHLPC GCIINCQPDT YSVAFDGKKS KRKGFEFNLS FQQSYGLYKM THADYYDDDD
ENPISYHNPK KYECEATKEP REDNHGVFNT ITVEISTTPP LDSATLTGVN KCTNTDIPEP
KQAVSEEKGA FSIKTECAIN YGEATSFEGP ERRLSHEETQ KPDLSDWEWC RSKSERTPRQ
RSGGGLAIPI CAFQGTVSLQ APTGKTLSLS TYEVSAEGQK ITPPSKKIEV YRSKSVGHEP
NSEESPSTFA DTNVKIHLEV LEICDNDEAL DTVSIISNIS QSSTKVRSPS LRYSRKENRF
VSCDLGETAS YSLFLPTSDP DGDINISIPD TVEAHRQNSR RQHQDRDGYQ EEIQLLNKAY
RKREAESKGN
