GP150_HUMAN
ID GP150_HUMAN Reviewed; 434 AA.
AC Q8NGU9; G4XH61; Q05C22;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable G-protein coupled receptor 150;
GN Name=GPR150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-316.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=15777626; DOI=10.1016/j.bbagen.2004.12.001;
RA Gloriam D.E., Schioth H.B., Fredriksson R.;
RT "Nine new human Rhodopsin family G-protein coupled receptors:
RT identification, sequence characterisation and evolutionary relationship.";
RL Biochim. Biophys. Acta 1722:235-246(2005).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB065678; BAC05903.1; -; Genomic_DNA.
DR EMBL; JF810884; AEP43751.1; -; mRNA.
DR EMBL; CH471084; EAW96041.1; -; Genomic_DNA.
DR EMBL; BC030197; AAH30197.1; -; mRNA.
DR EMBL; BK005422; DAA64837.1; -; mRNA.
DR CCDS; CCDS4074.1; -.
DR RefSeq; NP_954713.1; NM_199243.1.
DR AlphaFoldDB; Q8NGU9; -.
DR SMR; Q8NGU9; -.
DR BioGRID; 130155; 28.
DR STRING; 9606.ENSP00000369344; -.
DR ChEMBL; CHEMBL4523898; -.
DR iPTMnet; Q8NGU9; -.
DR PhosphoSitePlus; Q8NGU9; -.
DR BioMuta; GPR150; -.
DR DMDM; 54037146; -.
DR MassIVE; Q8NGU9; -.
DR PaxDb; Q8NGU9; -.
DR PeptideAtlas; Q8NGU9; -.
DR PRIDE; Q8NGU9; -.
DR ProteomicsDB; 73606; -.
DR Antibodypedia; 13054; 182 antibodies from 28 providers.
DR DNASU; 285601; -.
DR Ensembl; ENST00000380007.3; ENSP00000369344.2; ENSG00000178015.5.
DR GeneID; 285601; -.
DR KEGG; hsa:285601; -.
DR MANE-Select; ENST00000380007.3; ENSP00000369344.2; NM_199243.3; NP_954713.1.
DR UCSC; uc003kle.2; human.
DR CTD; 285601; -.
DR DisGeNET; 285601; -.
DR GeneCards; GPR150; -.
DR HGNC; HGNC:23628; GPR150.
DR HPA; ENSG00000178015; Tissue enhanced (brain, pancreas).
DR neXtProt; NX_Q8NGU9; -.
DR OpenTargets; ENSG00000178015; -.
DR PharmGKB; PA134984082; -.
DR VEuPathDB; HostDB:ENSG00000178015; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244841; -.
DR HOGENOM; CLU_009579_15_6_1; -.
DR InParanoid; Q8NGU9; -.
DR OMA; VYAFYEA; -.
DR OrthoDB; 1415066at2759; -.
DR PhylomeDB; Q8NGU9; -.
DR TreeFam; TF106499; -.
DR PathwayCommons; Q8NGU9; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR BioGRID-ORCS; 285601; 8 hits in 1061 CRISPR screens.
DR GeneWiki; GPR150; -.
DR GenomeRNAi; 285601; -.
DR Pharos; Q8NGU9; Tdark.
DR PRO; PR:Q8NGU9; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8NGU9; protein.
DR Bgee; ENSG00000178015; Expressed in body of pancreas and 75 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..434
FT /note="Probable G-protein coupled receptor 150"
FT /id="PRO_0000069630"
FT TOPO_DOM 1..3
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..334
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..434
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 188..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..203
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 46353 MW; 853429D1CF59253C CRC64;
MEDLFSPSIL PPAPNISVPI LLGWGLNLTL GQGAPASGPP SRRVRLVFLG VILVVAVAGN
TTVLCRLCGG GGPWAGPKRR KMDFLLVQLA LADLYACGGT ALSQLAWELL GEPRAATGDL
ACRFLQLLQA SGRGASAHLV VLIALERRRA VRLPHGRPLP ARALAALGWL LALLLALPPA
FVVRGDSPSP LPPPPPPTSL QPGAPPAARA WPGERRCHGI FAPLPRWHLQ VYAFYEAVAG
FVAPVTVLGV ACGHLLSVWW RHRPQAPAAA APWSASPGRA PAPSALPRAK VQSLKMSLLL
ALLFVGCELP YFAARLAAAW SSGPAGDWEG EGLSAALRVV AMANSALNPF VYLFFQAGDC
RLRRQLRKRL GSLCCAPQGG AEDEEGPRGH QALYRQRWPH PHYHHARREP LDEGGLRPPP
PRPRPLPCSC ESAF
