ID   GP151_RAT               Reviewed;         421 AA.
AC   Q7TSN5;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Probable G-protein coupled receptor 151;
DE   AltName: Full=GPCR-2037;
GN   Name=Gpr151;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=14667573; DOI=10.1016/j.molbrainres.2003.09.013;
RA   Berthold M., Collin M., Sejlitz T., Meister B., Lind P.;
RT   "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ
RT   hybridization reveals high mRNA expression in rat brain restricted to
RT   neurons of the habenular complex.";
RL   Brain Res. Mol. Brain Res. 120:22-29(2003).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in neurons of the habenular
CC       complex. The expression is particularly prominent in the medial
CC       habenular nucleus, whereas the lateral habenular nucleus exhibited a
CC       lower level of expression.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AJ564168; CAD91897.1; -; mRNA.
DR   RefSeq; NP_853664.1; NM_181633.2.
DR   AlphaFoldDB; Q7TSN5; -.
DR   SMR; Q7TSN5; -.
DR   STRING; 10116.ENSRNOP00000043810; -.
DR   GlyGen; Q7TSN5; 1 site.
DR   PhosphoSitePlus; Q7TSN5; -.
DR   PaxDb; Q7TSN5; -.
DR   Ensembl; ENSRNOT00000043544; ENSRNOP00000043810; ENSRNOG00000027103.
DR   GeneID; 307475; -.
DR   KEGG; rno:307475; -.
DR   UCSC; RGD:727873; rat.
DR   CTD; 134391; -.
DR   RGD; 727873; Gpr151.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01030000234518; -.
DR   HOGENOM; CLU_053982_0_0_1; -.
DR   InParanoid; Q7TSN5; -.
DR   OMA; YFWRAYG; -.
DR   OrthoDB; 658542at2759; -.
DR   PhylomeDB; Q7TSN5; -.
DR   TreeFam; TF332591; -.
DR   PRO; PR:Q7TSN5; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000027103; Expressed in spleen and 8 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0010447; P:response to acidic pH; ISO:RGD.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..421
FT                   /note="Probable G-protein coupled receptor 151"
FT                   /id="PRO_0000069634"
FT   TOPO_DOM        1..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..258
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..289
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        311..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          346..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   421 AA;  46724 MW;  5ADAE6CA69828512 CRC64;
     MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC LVGFVGNLCV
     IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT AYVKGVWDLG WFVCKSSDWF
     THMCMAAKSL TFVVVAKVCF MYASDPAKPV GTHNCTIWSL LGAIWVVASL LPLPEWFFST
     TRHHAGVEMC LVDVPAVAAE FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ
     NLRNQMRSKQ LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS
     ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP GKAPSPETQT
     CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP SAQDNDPIPW EHEGQETKGC
     N