GP153_HUMAN
ID GP153_HUMAN Reviewed; 609 AA.
AC Q6NV75; Q5TGR5; Q6AHW8; Q86SP8;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Probable G-protein coupled receptor 153;
DE AltName: Full=G-protein coupled receptor PGR1;
GN Name=GPR153; Synonyms=PGR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-209.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-326, AND VARIANT HIS-209.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-609.
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AL031847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC068275; AAH68275.1; -; mRNA.
DR EMBL; AY255529; AAO85041.1; -; mRNA.
DR EMBL; CR627473; CAH10674.1; -; mRNA.
DR CCDS; CCDS64.1; -.
DR RefSeq; NP_997253.2; NM_207370.3.
DR RefSeq; XP_011539736.1; XM_011541434.2.
DR RefSeq; XP_016856739.1; XM_017001250.1.
DR AlphaFoldDB; Q6NV75; -.
DR SMR; Q6NV75; -.
DR STRING; 9606.ENSP00000367125; -.
DR ChEMBL; CHEMBL4523876; -.
DR iPTMnet; Q6NV75; -.
DR PhosphoSitePlus; Q6NV75; -.
DR BioMuta; GPR153; -.
DR DMDM; 81170632; -.
DR MassIVE; Q6NV75; -.
DR PaxDb; Q6NV75; -.
DR PeptideAtlas; Q6NV75; -.
DR PRIDE; Q6NV75; -.
DR ProteomicsDB; 66715; -.
DR Antibodypedia; 1936; 242 antibodies from 30 providers.
DR DNASU; 387509; -.
DR Ensembl; ENST00000377893.3; ENSP00000367125.2; ENSG00000158292.7.
DR GeneID; 387509; -.
DR KEGG; hsa:387509; -.
DR MANE-Select; ENST00000377893.3; ENSP00000367125.2; NM_207370.4; NP_997253.2.
DR UCSC; uc001amp.2; human.
DR CTD; 387509; -.
DR DisGeNET; 387509; -.
DR GeneCards; GPR153; -.
DR HGNC; HGNC:23618; GPR153.
DR HPA; ENSG00000158292; Low tissue specificity.
DR neXtProt; NX_Q6NV75; -.
DR OpenTargets; ENSG00000158292; -.
DR PharmGKB; PA134929175; -.
DR VEuPathDB; HostDB:ENSG00000158292; -.
DR eggNOG; ENOG502QQA6; Eukaryota.
DR GeneTree; ENSGT00390000017213; -.
DR HOGENOM; CLU_031636_2_0_1; -.
DR InParanoid; Q6NV75; -.
DR OMA; YATLHSD; -.
DR OrthoDB; 294477at2759; -.
DR PhylomeDB; Q6NV75; -.
DR TreeFam; TF330832; -.
DR PathwayCommons; Q6NV75; -.
DR BioGRID-ORCS; 387509; 16 hits in 1070 CRISPR screens.
DR GeneWiki; GPR153; -.
DR GenomeRNAi; 387509; -.
DR Pharos; Q6NV75; Tdark.
DR PRO; PR:Q6NV75; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6NV75; protein.
DR Bgee; ENSG00000158292; Expressed in ileal mucosa and 188 other tissues.
DR ExpressionAtlas; Q6NV75; baseline and differential.
DR Genevisible; Q6NV75; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR022347; GCR_153/162.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR022335; GPR153.
DR PANTHER; PTHR16518; PTHR16518; 1.
DR PANTHER; PTHR16518:SF5; PTHR16518:SF5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01992; GPR153.
DR PRINTS; PR01991; GPR153GPR162.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..609
FT /note="Probable G-protein coupled receptor 153"
FT /id="PRO_0000069637"
FT TOPO_DOM 1..11
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..609
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 446..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..547
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 209
FT /note="R -> H (in dbSNP:rs12735670)"
FT /evidence="ECO:0000269|PubMed:12679517,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_023741"
SQ SEQUENCE 609 AA; 65361 MW; 7FEFA536BEB5ADE2 CRC64;
MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA ATHMLNVAVP
IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS VTSLSYHRMW MVCWPVNYRL
SNAKKQAVHT VMGIWMVSFI LSALPAVGWH DTSERFYTHG CRFIVAEIGL GFGVCFLLLV
GGSVAMGVIC TAIALFQTLA VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL
QTTGLVTTIV FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC
DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG DFVALDRMAK
YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA DVWAAVPLPA FLPRWGSGED
LAALAHLVLP AGPERRRASL LAFAEDAPPS RARRRSAESL LSLRPSALDS GPRGARDSPP
GSPRRRPGPG PRSASASLLP DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP
PSSAQRSPGP RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL
HSDSLGSAS
