GP153_MOUSE
ID GP153_MOUSE Reviewed; 631 AA.
AC Q8K0Z9; Q80T37; Q8CFK0;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Probable G-protein coupled receptor 153;
DE AltName: Full=G-protein coupled receptor PGR1;
GN Name=Gpr153; Synonyms=Pgr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-84.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC029098; AAH29098.2; -; mRNA.
DR EMBL; BC037650; AAH37650.1; -; mRNA.
DR EMBL; AY255610; AAO85122.1; -; mRNA.
DR CCDS; CCDS18996.1; -.
DR RefSeq; NP_848493.1; NM_178406.2.
DR AlphaFoldDB; Q8K0Z9; -.
DR BioGRID; 221387; 3.
DR STRING; 10090.ENSMUSP00000101276; -.
DR iPTMnet; Q8K0Z9; -.
DR PhosphoSitePlus; Q8K0Z9; -.
DR MaxQB; Q8K0Z9; -.
DR PaxDb; Q8K0Z9; -.
DR PRIDE; Q8K0Z9; -.
DR ProteomicsDB; 267653; -.
DR Antibodypedia; 1936; 242 antibodies from 30 providers.
DR DNASU; 100129; -.
DR Ensembl; ENSMUST00000055754; ENSMUSP00000052742; ENSMUSG00000042804.
DR Ensembl; ENSMUST00000105651; ENSMUSP00000101276; ENSMUSG00000042804.
DR GeneID; 100129; -.
DR KEGG; mmu:100129; -.
DR UCSC; uc008wab.1; mouse.
DR CTD; 387509; -.
DR MGI; MGI:1916157; Gpr153.
DR VEuPathDB; HostDB:ENSMUSG00000042804; -.
DR eggNOG; ENOG502QQA6; Eukaryota.
DR GeneTree; ENSGT00390000017213; -.
DR InParanoid; Q8K0Z9; -.
DR OMA; YATLHSD; -.
DR OrthoDB; 294477at2759; -.
DR PhylomeDB; Q8K0Z9; -.
DR TreeFam; TF330832; -.
DR BioGRID-ORCS; 100129; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Gpr153; mouse.
DR PRO; PR:Q8K0Z9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8K0Z9; protein.
DR Bgee; ENSMUSG00000042804; Expressed in mesenchyme of submandibular gland primordium and 135 other tissues.
DR ExpressionAtlas; Q8K0Z9; baseline and differential.
DR Genevisible; Q8K0Z9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR022347; GCR_153/162.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR022335; GPR153.
DR PANTHER; PTHR16518; PTHR16518; 1.
DR PANTHER; PTHR16518:SF5; PTHR16518:SF5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01992; GPR153.
DR PRINTS; PR01991; GPR153GPR162.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..631
FT /note="Probable G-protein coupled receptor 153"
FT /id="PRO_0000069638"
FT TOPO_DOM 1..11
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..631
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 486..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 68459 MW; AC171D496D66A797 CRC64;
MSDERRLPSS AVGWLACGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA ATHMLNVAVP
IATYAVVQLR RQRPDYEWNE GLCKVFVSTF YTLTLATCFS VTSISYHRMW MVRWPVNYRL
SNAKKQAVHT VMGIWMVSFI LSALPAVGWH DTSERFYTHG CRFIVAEIGL GFGVCFLLLV
GGSVAMGMVC TAIALFQTLA TQVGHRADRR TFTVPTIVVE DAQGKRRSSI DGSEPARTSL
QITGLVATIV VIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVTQA LLLPLFLWTC
DRYRADLKAV WEKCVALMAN DEDSDNETSL EGSISPDMVL ERSLDYSYGG DFVALDRMAK
YELSALEGGL PQLYPLRPLQ EDRMQYLQGA GRHRCGFPGG QPCFSPAGCS QVPPTRRFSH
DDADVWAAVP LPTFLPRWSS GEDLAALAHL MLPAGSDRRR GSLLAFAEDA PPFRPRRRSA
ESLLSLQPSS LDGGPRHAQD SPPGSPRRRP GPGARSASVS LLPDAFALTA FEREPQALRR
VPAPAQPFPA ARDSAEPAEV PTPPGGRTQR SQGRRAARTH VGPLQSSLSA SWGEPGGLHA
AGCGSISSFL SSPSESSGYV TLHSDSLGSA S
