GP155_HUMAN
ID GP155_HUMAN Reviewed; 870 AA.
AC Q7Z3F1; B2RCI2; D3DPE2; Q4G0Y6; Q53SJ3; Q53TA8; Q69YG8; Q86SP9; Q8N261;
AC Q8N639; Q8N8K3; Q96MV6;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Integral membrane protein GPR155;
DE AltName: Full=G-protein coupled receptor PGR22;
GN Name=GPR155; Synonyms=PGR22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-675.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71170.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK056381; BAB71170.1; ALT_INIT; mRNA.
DR EMBL; AK091200; BAC03609.1; -; mRNA.
DR EMBL; AK096665; BAC04835.1; -; mRNA.
DR EMBL; AK315125; BAG37579.1; -; mRNA.
DR EMBL; BX537947; CAD97915.1; -; mRNA.
DR EMBL; AL834154; CAH10683.1; -; mRNA.
DR EMBL; AC010894; AAY14707.1; -; Genomic_DNA.
DR EMBL; AC018470; AAY24218.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11137.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11138.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11139.1; -; Genomic_DNA.
DR EMBL; BC028730; AAH28730.1; -; mRNA.
DR EMBL; BC035037; AAH35037.1; -; mRNA.
DR EMBL; AY255528; AAO85040.1; -; mRNA.
DR CCDS; CCDS2259.1; -.
DR RefSeq; NP_001028217.1; NM_001033045.3.
DR RefSeq; NP_001253979.1; NM_001267050.1.
DR RefSeq; NP_001253980.1; NM_001267051.1.
DR RefSeq; NP_689742.4; NM_152529.6.
DR RefSeq; XP_016858974.1; XM_017003485.1.
DR RefSeq; XP_016858975.1; XM_017003486.1.
DR RefSeq; XP_016858976.1; XM_017003487.1.
DR AlphaFoldDB; Q7Z3F1; -.
DR SMR; Q7Z3F1; -.
DR BioGRID; 127389; 4.
DR IntAct; Q7Z3F1; 1.
DR STRING; 9606.ENSP00000376335; -.
DR GlyGen; Q7Z3F1; 8 sites.
DR iPTMnet; Q7Z3F1; -.
DR PhosphoSitePlus; Q7Z3F1; -.
DR BioMuta; GPR155; -.
DR DMDM; 68052330; -.
DR EPD; Q7Z3F1; -.
DR jPOST; Q7Z3F1; -.
DR MassIVE; Q7Z3F1; -.
DR MaxQB; Q7Z3F1; -.
DR PaxDb; Q7Z3F1; -.
DR PeptideAtlas; Q7Z3F1; -.
DR PRIDE; Q7Z3F1; -.
DR ProteomicsDB; 69044; -.
DR Antibodypedia; 50637; 156 antibodies from 12 providers.
DR DNASU; 151556; -.
DR Ensembl; ENST00000295500.8; ENSP00000295500.4; ENSG00000163328.14.
DR Ensembl; ENST00000392551.6; ENSP00000376334.2; ENSG00000163328.14.
DR Ensembl; ENST00000392552.7; ENSP00000376335.2; ENSG00000163328.14.
DR GeneID; 151556; -.
DR KEGG; hsa:151556; -.
DR MANE-Select; ENST00000392552.7; ENSP00000376335.2; NM_152529.7; NP_689742.4.
DR UCSC; uc002uit.5; human.
DR CTD; 151556; -.
DR DisGeNET; 151556; -.
DR GeneCards; GPR155; -.
DR HGNC; HGNC:22951; GPR155.
DR HPA; ENSG00000163328; Tissue enhanced (choroid plexus, stomach).
DR neXtProt; NX_Q7Z3F1; -.
DR OpenTargets; ENSG00000163328; -.
DR PharmGKB; PA134943679; -.
DR VEuPathDB; HostDB:ENSG00000163328; -.
DR eggNOG; ENOG502QQ69; Eukaryota.
DR GeneTree; ENSGT00390000004153; -.
DR HOGENOM; CLU_018490_0_0_1; -.
DR InParanoid; Q7Z3F1; -.
DR OMA; PHGLPEM; -.
DR OrthoDB; 228997at2759; -.
DR PhylomeDB; Q7Z3F1; -.
DR TreeFam; TF324034; -.
DR PathwayCommons; Q7Z3F1; -.
DR SignaLink; Q7Z3F1; -.
DR BioGRID-ORCS; 151556; 13 hits in 1067 CRISPR screens.
DR ChiTaRS; GPR155; human.
DR GeneWiki; GPR155; -.
DR GenomeRNAi; 151556; -.
DR Pharos; Q7Z3F1; Tbio.
DR PRO; PR:Q7Z3F1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q7Z3F1; protein.
DR Bgee; ENSG00000163328; Expressed in dorsal root ganglion and 186 other tissues.
DR ExpressionAtlas; Q7Z3F1; baseline and differential.
DR Genevisible; Q7Z3F1; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050890; P:cognition; IMP:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd04443; DEP_GPR155; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR037368; GPR155_DEP.
DR InterPro; IPR004776; Mem_trans.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF03547; Mem_trans; 2.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..870
FT /note="Integral membrane protein GPR155"
FT /id="PRO_0000087551"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 661..681
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 692..712
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 757..835
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 543
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 612
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="D -> G (in Ref. 1; BAC03609)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="K -> E (in Ref. 5; AAH28730)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="L -> H (in Ref. 1; BAB71170)"
FT /evidence="ECO:0000305"
FT CONFLICT 460
FT /note="W -> R (in Ref. 2; CAD97915)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="G -> A (in Ref. 2; CAH10683)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="S -> G (in Ref. 5; AAH28730)"
FT /evidence="ECO:0000305"
FT CONFLICT 638
FT /note="C -> R (in Ref. 2; CAD97915)"
FT /evidence="ECO:0000305"
FT CONFLICT 674
FT /note="S -> Y (in Ref. 5; AAH28730)"
FT /evidence="ECO:0000305"
FT CONFLICT 693
FT /note="Q -> R (in Ref. 2; CAH10683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 870 AA; 96919 MW; 91A6CFC79B669ACB CRC64;
MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF GIVLCGYIAG
RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW SFLYSILIAK ASVFFIVCVL
TLLVASPDSR FSKAGLFPIF ATQSNDFALG YPIVEALYQT TYPEYLQYIY LVAPISLMML
NPIGFIFCEI QKWKDTQNAS QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY
VENFLDGLGN SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL
LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS TFVSAPIMYV
SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI LLLSKKYKQL PHMLTTNLLI
AQSIVCAGMM IWNFVKEKNF VGQILVFVLL YSSLYSTYLW TGLLAISLFL LKKRERVQIP
VGIIIISGWG IPALLVGVLL ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM
CMNQTAQAGS YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG
ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS GDQQLTRHVL
LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN FGQGFISFGI FGLDKHLIIL
PFKRRLEFLW NNKDTAENRD SPVSEEIKMT CQQFIHYHRD LCIRNIVKER RCGAKTSAGT
FCGCDLVSWL IEVGLASDRG EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ
SPPAINANTL QQERYKEIEH SSPPSHSPKT
