GP156_HUMAN
ID GP156_HUMAN Reviewed; 814 AA.
AC Q8NFN8; B7ZL66; E9PFZ4; Q14CM1; Q86SN6;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable G-protein coupled receptor 156;
DE AltName: Full=G-protein coupled receptor PGR28;
DE AltName: Full=GABAB-related G-protein coupled receptor;
GN Name=GPR156; Synonyms=GABABL, PGR28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP ASP-516.
RX PubMed=12591167; DOI=10.1016/s0169-328x(02)00662-9;
RA Calver A.R., Michalovich D., Testa T.T., Robbins M.J., Jaillard C.,
RA Hill J., Szekeres P.G., Charles K.J., Jourdain S., Holbrook J.D.,
RA Boyfield I., Patel N., Medhurst A.D., Pangalos M.N.;
RT "Molecular cloning and characterization of a novel GABA(B)-related G-
RT protein coupled receptor.";
RL Brain Res. Mol. Brain Res. 110:305-317(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ASP-516.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-330 (ISOFORM 1).
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NFN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NFN8-2; Sequence=VSP_044603;
CC -!- TISSUE SPECIFICITY: Ubiquitous expression both in the CNS and in
CC peripheral tissues. Very high expression in fetal brain and testis
CC relative to expression in other tissues. {ECO:0000269|PubMed:12591167}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AF488739; AAN03795.1; -; mRNA.
DR EMBL; AC063952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113701; AAI13702.1; -; mRNA.
DR EMBL; BC143606; AAI43607.1; -; mRNA.
DR EMBL; AY255565; AAO85077.1; -; mRNA.
DR CCDS; CCDS2997.1; -. [Q8NFN8-1]
DR CCDS; CCDS54629.1; -. [Q8NFN8-2]
DR RefSeq; NP_001161743.1; NM_001168271.1. [Q8NFN8-2]
DR RefSeq; NP_694547.2; NM_153002.2. [Q8NFN8-1]
DR RefSeq; XP_005247222.1; XM_005247165.2.
DR RefSeq; XP_016861284.1; XM_017005795.1. [Q8NFN8-1]
DR RefSeq; XP_016861285.1; XM_017005796.1. [Q8NFN8-1]
DR RefSeq; XP_016861286.1; XM_017005797.1.
DR AlphaFoldDB; Q8NFN8; -.
DR SMR; Q8NFN8; -.
DR BioGRID; 127920; 75.
DR IntAct; Q8NFN8; 69.
DR STRING; 9606.ENSP00000417261; -.
DR ChEMBL; CHEMBL4523897; -.
DR TCDB; 9.A.14.15.4; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q8NFN8; 1 site.
DR iPTMnet; Q8NFN8; -.
DR PhosphoSitePlus; Q8NFN8; -.
DR BioMuta; GPR156; -.
DR DMDM; 296434518; -.
DR PaxDb; Q8NFN8; -.
DR PeptideAtlas; Q8NFN8; -.
DR PRIDE; Q8NFN8; -.
DR ProteomicsDB; 20211; -.
DR ProteomicsDB; 73328; -. [Q8NFN8-1]
DR Antibodypedia; 32788; 88 antibodies from 22 providers.
DR DNASU; 165829; -.
DR Ensembl; ENST00000461057.1; ENSP00000418758.1; ENSG00000175697.11. [Q8NFN8-2]
DR Ensembl; ENST00000464295.6; ENSP00000417261.1; ENSG00000175697.11. [Q8NFN8-1]
DR GeneID; 165829; -.
DR KEGG; hsa:165829; -.
DR MANE-Select; ENST00000464295.6; ENSP00000417261.1; NM_153002.3; NP_694547.2.
DR UCSC; uc011bjf.3; human. [Q8NFN8-1]
DR CTD; 165829; -.
DR GeneCards; GPR156; -.
DR HGNC; HGNC:20844; GPR156.
DR HPA; ENSG00000175697; Tissue enhanced (testis).
DR MIM; 610464; gene.
DR neXtProt; NX_Q8NFN8; -.
DR OpenTargets; ENSG00000175697; -.
DR PharmGKB; PA134918005; -.
DR VEuPathDB; HostDB:ENSG00000175697; -.
DR eggNOG; KOG1055; Eukaryota.
DR GeneTree; ENSGT00940000159755; -.
DR HOGENOM; CLU_350195_0_0_1; -.
DR InParanoid; Q8NFN8; -.
DR OMA; THFCASQ; -.
DR OrthoDB; 336447at2759; -.
DR PhylomeDB; Q8NFN8; -.
DR TreeFam; TF313965; -.
DR PathwayCommons; Q8NFN8; -.
DR SignaLink; Q8NFN8; -.
DR BioGRID-ORCS; 165829; 18 hits in 1072 CRISPR screens.
DR ChiTaRS; GPR156; human.
DR GeneWiki; GPR156; -.
DR GenomeRNAi; 165829; -.
DR Pharos; Q8NFN8; Tdark.
DR PRO; PR:Q8NFN8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NFN8; protein.
DR Bgee; ENSG00000175697; Expressed in ventricular zone and 127 other tissues.
DR ExpressionAtlas; Q8NFN8; baseline and differential.
DR Genevisible; Q8NFN8; HS.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15292; 7tmC_GPR156; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041946; GPR156_7TM.
DR PANTHER; PTHR10519; PTHR10519; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Coiled coil;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..814
FT /note="Probable G-protein coupled receptor 156"
FT /id="PRO_0000206899"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..814
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 422..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 354..390
FT /evidence="ECO:0000255"
FT COMPBIAS 437..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 197..200
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044603"
FT VARIANT 516
FT /note="E -> D (in dbSNP:rs902790)"
FT /evidence="ECO:0000269|PubMed:12591167,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_049284"
SQ SEQUENCE 814 AA; 89097 MW; 496B0654A26B4ADB CRC64;
MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL GIVWTFLSCG
LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDV LVGSSMETLI
QTRLSMLCIG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALLMADVILL
MTWVLTDPIQ CLQILSVSMT VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA
YLAGLTGHVS SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH PRGEKSSMER
LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA PPASSPNKDV QAVASVHTLA
AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS SYAQSLEGPG KDSSFSPGKE EKISDSKDFS
DHLDSGCSQK PWTEQSLGPE RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR
VSSVIREKLQ EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR
RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT DSRVRRPSSR
KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS GSGRAPSPAA PCLSKASPDL
PEQWQLWPPV PSGCASLSSQ HSYFDTESSS SDEFFCRCHR PYCEICFQSS SDSSDSGTSD
TDPEPTGGLA SWEKLWARSK PIVNFKDDLK PTLV
