GP156_MOUSE
ID GP156_MOUSE Reviewed; 798 AA.
AC Q6PCP7; Q8K452;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Probable G-protein coupled receptor 156;
DE AltName: Full=GABAB-related G-protein coupled receptor;
GN Name=Gpr156; Synonyms=Gababl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=12591167; DOI=10.1016/s0169-328x(02)00662-9;
RA Calver A.R., Michalovich D., Testa T.T., Robbins M.J., Jaillard C.,
RA Hill J., Szekeres P.G., Charles K.J., Jourdain S., Holbrook J.D.,
RA Boyfield I., Patel N., Medhurst A.D., Pangalos M.N.;
RT "Molecular cloning and characterization of a novel GABA(B)-related G-
RT protein coupled receptor.";
RL Brain Res. Mol. Brain Res. 110:305-317(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC Postsynaptic cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AF488740; AAN03796.1; -; mRNA.
DR EMBL; BC059227; AAH59227.1; -; mRNA.
DR CCDS; CCDS28162.1; -.
DR RefSeq; NP_700443.2; NM_153394.2.
DR AlphaFoldDB; Q6PCP7; -.
DR SMR; Q6PCP7; -.
DR STRING; 10090.ENSMUSP00000055958; -.
DR GlyGen; Q6PCP7; 1 site.
DR iPTMnet; Q6PCP7; -.
DR PhosphoSitePlus; Q6PCP7; -.
DR PaxDb; Q6PCP7; -.
DR PRIDE; Q6PCP7; -.
DR DNASU; 239845; -.
DR GeneID; 239845; -.
DR KEGG; mmu:239845; -.
DR UCSC; uc007zel.1; mouse.
DR CTD; 165829; -.
DR MGI; MGI:2653880; Gpr156.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; Q6PCP7; -.
DR OrthoDB; 336447at2759; -.
DR PhylomeDB; Q6PCP7; -.
DR TreeFam; TF313965; -.
DR BioGRID-ORCS; 239845; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Gpr156; mouse.
DR PRO; PR:Q6PCP7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6PCP7; protein.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15292; 7tmC_GPR156; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041946; GPR156_7TM.
DR PANTHER; PTHR10519; PTHR10519; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; G-protein coupled receptor; Glycoprotein;
KW Membrane; Postsynaptic cell membrane; Receptor; Reference proteome;
KW Synapse; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..798
FT /note="Probable G-protein coupled receptor 156"
FT /id="PRO_0000206900"
FT TOPO_DOM 1..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..798
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 441..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 353..390
FT /evidence="ECO:0000255"
FT COMPBIAS 446..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 341
FT /note="S -> G (in Ref. 2; AAH59227)"
FT /evidence="ECO:0000305"
FT CONFLICT 484
FT /note="S -> R (in Ref. 1; AAN03796)"
FT /evidence="ECO:0000305"
FT CONFLICT 569
FT /note="Q -> R (in Ref. 1; AAN03796)"
FT /evidence="ECO:0000305"
FT CONFLICT 573
FT /note="P -> T (in Ref. 1; AAN03796)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="V -> I (in Ref. 1; AAN03796)"
FT /evidence="ECO:0000305"
FT CONFLICT 629
FT /note="L -> Q (in Ref. 1; AAN03796)"
FT /evidence="ECO:0000305"
FT CONFLICT 632
FT /note="H -> N (in Ref. 2; AAH59227)"
FT /evidence="ECO:0000305"
FT CONFLICT 777
FT /note="E -> G (in Ref. 2; AAH59227)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 798 AA; 87040 MW; A4DDCA5F42752BAC CRC64;
MEPEINCSEF CDSFPGQELD RRPLHDLCKT TITESQHSST AASPLSPALL GIMWTFLSCG
LLLVLFFLAF TIRCRKNRIV KMSSPNLNVV TLLGSCLTYI SAYLFGIQDA LEGSSVEALI
QTRLSLLCIG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALVVADVILL
VTWVLTDPIQ CLQMLGVSMK VTGRDVSCSL TNTHFCASRY SDVWIALVLG CKGLLLLYGA
YLAGLTNHVS SPPVNQSLTI MVGVNLLLLT AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
TTVNCCVFIP QLKQWKAFEG ENQTMRHMAK YFSTPSKSFH SQFDEDPSCH LRDEKSCMER
LLTEKNAVIE SLQEQVSNAK EKLVKLMSAE CTYDSPEWAV PDAASARGLA LPGPSECPAV
SENESGAAAR DSLHVPAACQ HVQGPGASRR DTSPSPAQQD NMPLKQYCDH LDTGCNQKPK
AEQSEGPERG DQEPMAPSQR LMADGVACEP HKPRQSPEGL PKKLPGVSSV VREKLQEVLQ
ELDLGSEAPL SPLPCPQQLW KSTTSRSPQK LSPSKLGFSP YVVRRRRAAQ RARSHIPGSV
GLNVGHQANS TVSSSQSGLI VQNRDSPRLD HHNARSKVPR SSSVKPSPLS EPRRKQGTLE
GSKQCETEPQ EAGGACNVAF PCQSSASVQA QSPAAPCLPS SPALPRQRQP RPRLSPGCPS
LSSGCYNLDS ESSSSDEFFC RCHRPYCEIC FQSSLDSNDS DTSDSDLEQA SGLASWEKLW
ARSKPVVNFK DDLKPTLV
