GP156_RAT
ID GP156_RAT Reviewed; 792 AA.
AC Q8K451;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 02-JUN-2021, entry version 84.
DE RecName: Full=Probable G-protein coupled receptor 156;
DE AltName: Full=GABAB-related G-protein coupled receptor;
GN Name=Gpr156; Synonyms=Gababl;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=12591167; DOI=10.1016/s0169-328x(02)00662-9;
RA Calver A.R., Michalovich D., Testa T.T., Robbins M.J., Jaillard C.,
RA Hill J., Szekeres P.G., Charles K.J., Jourdain S., Holbrook J.D.,
RA Boyfield I., Patel N., Medhurst A.D., Pangalos M.N.;
RT "Molecular cloning and characterization of a novel GABA(B)-related G-
RT protein coupled receptor.";
RL Brain Res. Mol. Brain Res. 110:305-317(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed throughout the brain and is
CC particularly dense in the olfactory tubercles, islands of Calleja,
CC nucleus accumbens, piriform cortex and all fields of the hippocampus.
CC {ECO:0000269|PubMed:12591167}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AF488741; AAN03797.1; -; mRNA.
DR RefSeq; NP_695207.1; NM_153295.1.
DR STRING; 10116.ENSRNOP00000003773; -.
DR GlyGen; Q8K451; 1 site.
DR iPTMnet; Q8K451; -.
DR PhosphoSitePlus; Q8K451; -.
DR PaxDb; Q8K451; -.
DR PRIDE; Q8K451; -.
DR GeneID; 260430; -.
DR KEGG; rno:260430; -.
DR UCSC; RGD:708438; rat.
DR CTD; 165829; -.
DR RGD; 708438; Gpr156.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; Q8K451; -.
DR OrthoDB; 336447at2759; -.
DR PhylomeDB; Q8K451; -.
DR PRO; PR:Q8K451; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15292; 7tmC_GPR156; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041946; GPR156_7TM.
DR PANTHER; PTHR10519; PTHR10519; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..792
FT /note="Probable G-protein coupled receptor 156"
FT /id="PRO_0000206901"
FT TOPO_DOM 1..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..792
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 407..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 354..390
FT /evidence="ECO:0000255"
FT COMPBIAS 552..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 792 AA; 86426 MW; 17E252E8AC8F8FFB CRC64;
MEPEINCSEF CDSFPGQELD RRPLHDLCKT TITDSQHGSA DISPLSPALL GVIWTFLSCG
LLLVLFFLAF TIRCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDA LVGSSVEALI
QTRLSLLCIG TTLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALVVADVILL
VTWVLTDPIQ CLQILGVSMK VTGRDVSCSL TNTHFCASRY SDVWIALVLG CKGLLLLYGA
YLAGLTNHVS SPPVNQSLTI MVGVNLLLLT AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
TTVNCCVFLP QLRQRKAFEG ENQTIRHMAK YFSTPSKTFR SKFDEDQSCH LRDEXSCMER
LLTEKNAVIE SLQEQVSNAK EKLVKLMSAE CALDSPEWAV PAAASAGGPA ECXATSEKES
GAAAEDSLPA SAASQHMQGP GASRRDXSPS PDQKYDMPLK QFCDHLDMGC SQKPKAEQSE
GPERGNQEPM APGQSLMTDG VACEPHRPRQ NSEVLPERLP RVSSVVREKL QEVLQELDLG
TEAPLSPLPC PQQPWKSNTS GSPQKLSPSK LGFSPYVVRR RRAAQRARSR IPGSVGLKMG
HQANNTVSGS QNGLIVQNRD SPRLDHHNAR SKEPRSSSVK PSPISAPHQR RGSLEGSKQC
ETEPQEARGY SVAFPRQPSA SAPAQSSTAP CLSSXPALPR QRQPLPLLSP GCPSLSSGCY
NLDSESSSSD EFFCRCHRPY CEICFQSSLD SNDSDTSDSD LEQTSGLASW EKLLARSKPV
VNFKDDLKPT LV
