GP157_HUMAN
ID GP157_HUMAN Reviewed; 335 AA.
AC Q5UAW9; A2A334; Q8WWB8; Q9HA73;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=G-protein coupled receptor 157;
GN Name=GPR157;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta, and Prostate;
RA Bonner T.I., Kauffman D., Nagle J.W.;
RT "Complete coding sequence of GPR157.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Orphan receptor that promotes neuronal differentiation of
CC radial glial progenitors (RGPs). The activity of this receptor is
CC mediated by a G(q)-protein that activates a phosphatidylinositol-
CC calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000250|UniProtKB:Q8C206}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Expressed in the primary cilia of radial glial
CC progenitors (RGPs) exposed to the cerebrospinal fluid.
CC {ECO:0000250|UniProtKB:Q8C206}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13982.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AY768808; AAV35060.1; -; mRNA.
DR EMBL; AL158048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK022194; BAB13982.1; ALT_SEQ; mRNA.
DR CCDS; CCDS100.2; -.
DR RefSeq; NP_079256.4; NM_024980.4.
DR AlphaFoldDB; Q5UAW9; -.
DR SMR; Q5UAW9; -.
DR BioGRID; 123089; 1.
DR STRING; 9606.ENSP00000366628; -.
DR ChEMBL; CHEMBL4523875; -.
DR iPTMnet; Q5UAW9; -.
DR PhosphoSitePlus; Q5UAW9; -.
DR BioMuta; GPR157; -.
DR DMDM; 73621015; -.
DR EPD; Q5UAW9; -.
DR jPOST; Q5UAW9; -.
DR MassIVE; Q5UAW9; -.
DR MaxQB; Q5UAW9; -.
DR PaxDb; Q5UAW9; -.
DR PeptideAtlas; Q5UAW9; -.
DR PRIDE; Q5UAW9; -.
DR ProteomicsDB; 65242; -.
DR Antibodypedia; 27668; 131 antibodies from 23 providers.
DR DNASU; 80045; -.
DR Ensembl; ENST00000377411.5; ENSP00000366628.4; ENSG00000180758.12.
DR GeneID; 80045; -.
DR KEGG; hsa:80045; -.
DR MANE-Select; ENST00000377411.5; ENSP00000366628.4; NM_024980.5; NP_079256.4.
DR UCSC; uc001apq.2; human.
DR CTD; 80045; -.
DR DisGeNET; 80045; -.
DR GeneCards; GPR157; -.
DR HGNC; HGNC:23687; GPR157.
DR HPA; ENSG00000180758; Tissue enhanced (skeletal).
DR neXtProt; NX_Q5UAW9; -.
DR OpenTargets; ENSG00000180758; -.
DR PharmGKB; PA134876230; -.
DR VEuPathDB; HostDB:ENSG00000180758; -.
DR eggNOG; ENOG502QU1X; Eukaryota.
DR GeneTree; ENSGT00390000012992; -.
DR HOGENOM; CLU_052670_0_0_1; -.
DR InParanoid; Q5UAW9; -.
DR OMA; RHIHIAH; -.
DR OrthoDB; 1476889at2759; -.
DR PhylomeDB; Q5UAW9; -.
DR TreeFam; TF330856; -.
DR PathwayCommons; Q5UAW9; -.
DR BioGRID-ORCS; 80045; 8 hits in 1060 CRISPR screens.
DR ChiTaRS; GPR157; human.
DR GeneWiki; GPR157; -.
DR GenomeRNAi; 80045; -.
DR Pharos; Q5UAW9; Tdark.
DR PRO; PR:Q5UAW9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5UAW9; protein.
DR Bgee; ENSG00000180758; Expressed in esophagus squamous epithelium and 137 other tissues.
DR ExpressionAtlas; Q5UAW9; baseline and differential.
DR Genevisible; Q5UAW9; HS.
DR GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048512; P:circadian behavior; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISS:UniProtKB.
DR GO; GO:0060019; P:radial glial cell differentiation; ISS:UniProtKB.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00002; 7tm_2; 1.
DR PRINTS; PR02001; GCR1CAMPR.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Developmental protein; Differentiation;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..335
FT /note="G-protein coupled receptor 157"
FT /id="PRO_0000070339"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 300..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 71
FT /note="N -> D (in Ref. 3; BAB13982)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 36623 MW; C779B2D16C6D560C CRC64;
MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS
AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLSIVR AARGPRTDRL
LWAFHVVSWG VPLVITVAAV ALKKIGYDAS DVSVGWCWID LEAKDHVLWM LLTGKLWEML
AYVLLPLLYL LVRKHINRAH TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW
STVRFVLTLC GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS
QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST
