GP157_MOUSE
ID GP157_MOUSE Reviewed; 330 AA.
AC Q8C206; Q8C224;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=G-protein coupled receptor 157;
GN Name=Gpr157;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP LOCATION.
RX PubMed=27142930; DOI=10.1038/srep25180;
RA Takeo Y., Kurabayashi N., Nguyen M.D., Sanada K.;
RT "The G protein-coupled receptor GPR157 regulates neuronal differentiation
RT of radial glial progenitors through the Gq-IP3 pathway.";
RL Sci. Rep. 6:25180-25180(2016).
CC -!- FUNCTION: Orphan receptor that promotes neuronal differentiation of
CC radial glial progenitors (RGPs) (PubMed:27142930). The activity of this
CC receptor is mediated by a G(q)-protein that activates a
CC phosphatidylinositol-calcium second messenger (PubMed:27142930).
CC {ECO:0000269|PubMed:27142930}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000269|PubMed:27142930}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Expressed in the primary cilia of radial glial
CC progenitors (RGPs) exposed to the cerebrospinal fluid.
CC {ECO:0000269|PubMed:27142930}.
CC -!- TISSUE SPECIFICITY: Expressed in the primary cilia of radial glial
CC progenitors (RGPs) in the developing neocortex (PubMed:27142930).
CC {ECO:0000269|PubMed:27142930}.
CC -!- DEVELOPMENTAL STAGE: Preferential expression during the early to mid
CC stages of corticogenesis. High levels in the early radial glial
CC progenitors from 10 to 17 dpc and gradually decrease thereafter (at
CC protein level) (PubMed:27142930). {ECO:0000269|PubMed:27142930}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
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DR EMBL; AK089544; BAC40921.1; -; mRNA.
DR EMBL; AK089429; BAC40879.1; -; mRNA.
DR CCDS; CCDS38977.1; -.
DR RefSeq; NP_796340.2; NM_177366.3.
DR AlphaFoldDB; Q8C206; -.
DR SMR; Q8C206; -.
DR STRING; 10090.ENSMUSP00000092020; -.
DR iPTMnet; Q8C206; -.
DR PhosphoSitePlus; Q8C206; -.
DR PaxDb; Q8C206; -.
DR PRIDE; Q8C206; -.
DR Antibodypedia; 27668; 131 antibodies from 23 providers.
DR DNASU; 269604; -.
DR Ensembl; ENSMUST00000094451; ENSMUSP00000092020; ENSMUSG00000047875.
DR GeneID; 269604; -.
DR KEGG; mmu:269604; -.
DR UCSC; uc008vxj.1; mouse.
DR CTD; 80045; -.
DR MGI; MGI:2442046; Gpr157.
DR VEuPathDB; HostDB:ENSMUSG00000047875; -.
DR eggNOG; ENOG502QU1X; Eukaryota.
DR GeneTree; ENSGT00390000012992; -.
DR HOGENOM; CLU_052670_0_0_1; -.
DR InParanoid; Q8C206; -.
DR OMA; RHIHIAH; -.
DR OrthoDB; 1476889at2759; -.
DR PhylomeDB; Q8C206; -.
DR TreeFam; TF330856; -.
DR BioGRID-ORCS; 269604; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Gpr157; mouse.
DR PRO; PR:Q8C206; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C206; protein.
DR Bgee; ENSMUSG00000047875; Expressed in hindlimb stylopod muscle and 46 other tissues.
DR ExpressionAtlas; Q8C206; baseline and differential.
DR GO; GO:0060170; C:ciliary membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048512; P:circadian behavior; IMP:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:UniProtKB.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IMP:UniProtKB.
DR GO; GO:0060019; P:radial glial cell differentiation; IMP:UniProtKB.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00002; 7tm_2; 1.
DR PRINTS; PR02001; GCR1CAMPR.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Developmental protein; Differentiation;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="G-protein coupled receptor 157"
FT /id="PRO_0000070340"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 301..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 296
FT /note="C -> W (in Ref. 1; BAC40879)"
FT /evidence="ECO:0000305"
FT CONFLICT 326..330
FT /note="EVPST -> RSAQHSGWLSSLSVLALPSWFLLQD (in Ref. 1;
FT BAC40879)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36344 MW; D2A1F08B4365A2DA CRC64;
MPSPAPPTEL LPWERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS
AASYFYGVLQ DFAGTSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLSIVR TTRGPSTDHL
IWAFHLISWG VPLAITVAAV SLKKIGYDAS DVSVGWCWIN LEAEDRVLWM LLTGKLWEML
AYILLPLLYL LVRKHINRAH QALSEYRPIC EGRQLQRGSS TSTADKKLVL IPLIFICLRV
WSTVRFVLTL CGSPAVQTPV LVVLHGIGNT FQGGANCIMF VLCTRAVRTR LFSLCCCCPR
PSTQSPPGAP TPPKIGESQE SRRTPEVPST
