GP157_RAT
ID GP157_RAT Reviewed; 330 AA.
AC Q5FVG1;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=G-protein coupled receptor 157;
GN Name=Gpr157;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor that promotes neuronal differentiation of
CC radial glial progenitors (RGPs). The activity of this receptor is
CC mediated by a G(q)-protein that activates a phosphatidylinositol-
CC calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000250|UniProtKB:Q8C206}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Expressed in the primary cilia of radial glial
CC progenitors (RGPs) exposed to the cerebrospinal fluid.
CC {ECO:0000250|UniProtKB:Q8C206}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
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DR EMBL; BC090013; AAH90013.1; -; mRNA.
DR RefSeq; NP_001012107.1; NM_001012107.1.
DR AlphaFoldDB; Q5FVG1; -.
DR SMR; Q5FVG1; -.
DR STRING; 10116.ENSRNOP00000052398; -.
DR PhosphoSitePlus; Q5FVG1; -.
DR PaxDb; Q5FVG1; -.
DR Ensembl; ENSRNOT00000055536; ENSRNOP00000052398; ENSRNOG00000017528.
DR GeneID; 313725; -.
DR KEGG; rno:313725; -.
DR UCSC; RGD:1311096; rat.
DR CTD; 80045; -.
DR RGD; 1311096; Gpr157.
DR eggNOG; ENOG502QU1X; Eukaryota.
DR GeneTree; ENSGT00390000012992; -.
DR HOGENOM; CLU_052670_0_0_1; -.
DR InParanoid; Q5FVG1; -.
DR OMA; RHIHIAH; -.
DR OrthoDB; 1476889at2759; -.
DR PhylomeDB; Q5FVG1; -.
DR TreeFam; TF330856; -.
DR PRO; PR:Q5FVG1; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000017528; Expressed in quadriceps femoris and 18 other tissues.
DR GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048512; P:circadian behavior; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISS:UniProtKB.
DR GO; GO:0060019; P:radial glial cell differentiation; ISS:UniProtKB.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00002; 7tm_2; 1.
DR PRINTS; PR02001; GCR1CAMPR.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Developmental protein; Differentiation;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="G-protein coupled receptor 157"
FT /id="PRO_0000070341"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 303..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 36687 MW; 3EBB6F486CF77151 CRC64;
MPTPAPPTEL LPWERAVVLL SCVLSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS
AASYFYGVLQ DFAGTSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLNIVR ATRGPCTDHL
VWAFHLISWG VPLAITVAAV CLKKIGYDAS DVSVGWCWIN LEAEDRVLWM LLTGKLWEML
AYILLPLLYL LVRKHINRAH QALSEYRPIW EGRQLQRGSP TSMADKKLIL IPFIFICLRV
WSTVRFVLTL CGSPVVQAPV LVVLHGIGNT FQGGANCIMF VLCTRAVRTR LFSLCCCYPR
PPTQNPPGAS IPPKMGESQE SRRTPEVPST
