GP158_MOUSE
ID GP158_MOUSE Reviewed; 1200 AA.
AC Q8C419; B1AWY4; Q8CHB0;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Probable G-protein coupled receptor 158;
DE Flags: Precursor;
GN Name=Gpr158; Synonyms=Kiaa1136;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-724.
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1200.
RC TISSUE=Brain;
RX PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 9:179-188(2002).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694; SER-705; SER-708;
RP SER-865; SER-944 AND SER-1059, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC Q8C419; P35052: GPC1; Xeno; NbExp=3; IntAct=EBI-776313, EBI-8307554;
CC Q8C419; P78333: GPC5; Xeno; NbExp=2; IntAct=EBI-776313, EBI-2558325;
CC Q8C419; P31431: SDC4; Xeno; NbExp=3; IntAct=EBI-776313, EBI-3913237;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; AL772387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL928939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK083234; BAC38819.1; -; mRNA.
DR EMBL; AB093287; BAC41471.1; -; mRNA.
DR CCDS; CCDS15722.1; -.
DR RefSeq; NP_001004761.1; NM_001004761.1.
DR AlphaFoldDB; Q8C419; -.
DR SMR; Q8C419; -.
DR BioGRID; 232299; 3.
DR IntAct; Q8C419; 15.
DR MINT; Q8C419; -.
DR STRING; 10090.ENSMUSP00000049708; -.
DR GlyConnect; 2605; 5 N-Linked glycans (3 sites).
DR GlyGen; Q8C419; 5 sites, 5 N-linked glycans (3 sites).
DR iPTMnet; Q8C419; -.
DR PhosphoSitePlus; Q8C419; -.
DR SwissPalm; Q8C419; -.
DR MaxQB; Q8C419; -.
DR PaxDb; Q8C419; -.
DR PeptideAtlas; Q8C419; -.
DR PRIDE; Q8C419; -.
DR ProteomicsDB; 271135; -.
DR Antibodypedia; 2922; 101 antibodies from 19 providers.
DR DNASU; 241263; -.
DR Ensembl; ENSMUST00000055946; ENSMUSP00000049708; ENSMUSG00000045967.
DR GeneID; 241263; -.
DR KEGG; mmu:241263; -.
DR UCSC; uc008ine.1; mouse.
DR CTD; 57512; -.
DR MGI; MGI:2441697; Gpr158.
DR VEuPathDB; HostDB:ENSMUSG00000045967; -.
DR eggNOG; KOG4418; Eukaryota.
DR GeneTree; ENSGT00940000155918; -.
DR HOGENOM; CLU_006832_1_0_1; -.
DR InParanoid; Q8C419; -.
DR OMA; THVCLPC; -.
DR OrthoDB; 63351at2759; -.
DR PhylomeDB; Q8C419; -.
DR TreeFam; TF319114; -.
DR BioGRID-ORCS; 241263; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Gpr158; mouse.
DR PRO; PR:Q8C419; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8C419; protein.
DR Bgee; ENSMUSG00000045967; Expressed in superior frontal gyrus and 74 other tissues.
DR Genevisible; Q8C419; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0072659; P:protein localization to plasma membrane; IDA:MGI.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; PTHR32546; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Isopeptide bond;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix; Ubl conjugation.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1200
FT /note="Probable G-protein coupled receptor 158"
FT /id="PRO_0000012970"
FT TOPO_DOM 25..417
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 439..451
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..483
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..506
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 507..528
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 529..549
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 550..579
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 601..613
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 614..634
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 635..643
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 644..664
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 665..1200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 25..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 694
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 705
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 708
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 865
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 944
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1059
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1074
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:D4A6L0"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 333
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CROSSLNK 774
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q5T848"
SQ SEQUENCE 1200 AA; 134426 MW; 2FCEF8283DE964B4 CRC64;
MGAMAYSLLF CLLLAHLGLG EVGASLDPPG RPDSPRERTP RGKQHGQQLP RASAPDPSIP
WSRSTDGTIL AQKLAEEVPV DVASYLYTGD FHQLKRANCS GRYELAGLPG KSPSLASSHP
SLHGALDTLT HATNFLNMML QSNKSREQTV QDDLQWYQAL VRSLLEGEPS ISRAAITFST
ESLSTPAPQV FLQATREESR ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN
QGPRGLGHSW RRRDGLGGDR SHVKWSPPYL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF
RGVMKVDISL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY QCICKAGFYH
PRVFSVNNFQ RRGPDHHFSG STKDVSEETH VCLPCREGCP FCADDRPCFV QEDKYLRLAI
ISFQALCMLL DFVSMLVVYH FRKAKSIRAS GLILLETILF GSLLLYFPVV ILYFEPSTFR
CILLRWARLL GFATVYGTVT LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF
LVGWTSSMCQ NLERDILLVG QGQTSDHLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH AHLTVTVTIG
LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI NSAWSEHSLD PEDIRDELKK
LYAQLEIYKR KKMITNNPHL QKKRCSKKGL GRSIMRRITE IPETVSRQCS KEDKEGTDHS
AAKGTGLVRK NPTESSGNTG RPKEESLKNR VFSLKKSHST YDHVRDQTVE SSSLPMESQE
EEATENSTLE SLSSKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPKDRETI RKYSNSDNVE TIPNSGHMEE
PRKPQKSGIM KQQRVSLPTA NPDVSSGITQ IKDNFDIGEV CPWEVYDLTP GPMPSEPKAQ
KHVSIAASEV EQNPASFLKE KSYHKSKATE GLYQANHKSI DKTEVCPWEI HSQSLLEDEN
RLISKTPVLP GRAREENGSQ LYTTNMCAGQ YEELPHKVVA PKVENENLNQ MGDQEKQTSS
SVDIIPGSCN SSNNSHQPLT SRAEVCPWEF EPLEQPNAER SVTLPASSAL SANKIPGPQK
