GP15L_MOUSE
ID GP15L_MOUSE Reviewed; 78 AA.
AC A0A0B4J1N3;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 04-MAR-2015, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Protein GPR15L {ECO:0000303|PubMed:28936214};
DE Flags: Precursor;
GN Name=Gpr15l {ECO:0000303|PubMed:28936214};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=28936214; DOI=10.3389/fimmu.2017.01111;
RA Ocon B., Pan J., Dinh T.T., Chen W., Ballet R., Bscheider M., Habtezion A.,
RA Tu H., Zabel B.A., Butcher E.C.;
RT "A mucosal and cutaneous chemokine ligand for the lymphocyte
RT chemoattractant receptor GPR15.";
RL Front. Immunol. 8:1111-1111(2017).
RN [4]
RP TISSUE SPECIFICITY, INDUCTION BY IMIQUIMOD, AND FUNCTION.
RX PubMed=28900043; DOI=10.1126/scisignal.aal0180;
RA Suply T., Hannedouche S., Carte N., Li J., Grosshans B., Schaefer M.,
RA Raad L., Beck V., Vidal S., Hiou-Feige A., Beluch N., Barbieri S.,
RA Wirsching J., Lageyre N., Hillger F., Debon C., Dawson J., Smith P.,
RA Lannoy V., Detheux M., Bitsch F., Falchetto R., Bouwmeester T., Porter J.,
RA Baumgarten B., Mansfield K., Carballido J.M., Seuwen K., Bassilana F.;
RT "A natural ligand for the orphan receptor GPR15 modulates lymphocyte
RT recruitment to epithelia.";
RL Sci. Signal. 10:0-0(2017).
CC -!- FUNCTION: Chemotactic factor that mediates lymphocytes recruitment to
CC epithelia through binding and activation of the G-protein coupled
CC receptor GPR15 (PubMed:28900043,PubMed:28936214). May be a tumor
CC suppressor; together with SUSD2 has a growth inhibitory effect on colon
CC cancer cells which includes G1 cell cycle arrest (By similarity).
CC {ECO:0000250|UniProtKB:Q6UWK7, ECO:0000269|PubMed:28900043,
CC ECO:0000269|PubMed:28936214}.
CC -!- FUNCTION: Has antimicrobial activity against Gram-positive bacteria,
CC including Staphylococcus aureus and Actinomyces spec., and Mycoplasma
CC hominis and lentivirus. {ECO:0000250|UniProtKB:Q6UWK7}.
CC -!- SUBUNIT: Interacts with SUSD2; the interaction is direct.
CC {ECO:0000250|UniProtKB:Q6UWK7}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UWK7}.
CC -!- TISSUE SPECIFICITY: Highly abundant in the testis, colon, eye, and
CC tongue. Detected in the epithelial layer of the colon, but not the
CC small intestine. {ECO:0000269|PubMed:28900043,
CC ECO:0000269|PubMed:28936214}.
CC -!- INDUCTION: Up-regulated by Imiquimod in the skin (PubMed:28900043).
CC {ECO:0000269|PubMed:28900043}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CT009495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466573; EDL24898.1; -; Genomic_DNA.
DR CCDS; CCDS56949.1; -.
DR RefSeq; NP_001193613.1; NM_001206684.1.
DR AlphaFoldDB; A0A0B4J1N3; -.
DR STRING; 10090.ENSMUSP00000136426; -.
DR PaxDb; A0A0B4J1N3; -.
DR Antibodypedia; 62671; 7 antibodies from 6 providers.
DR Ensembl; ENSMUST00000179488; ENSMUSP00000136426; ENSMUSG00000096001.
DR GeneID; 70045; -.
DR KEGG; mmu:70045; -.
DR MGI; MGI:1917295; 2610528A11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000096001; -.
DR eggNOG; ENOG502TD47; Eukaryota.
DR GeneTree; ENSGT00390000015172; -.
DR HOGENOM; CLU_195436_0_0_1; -.
DR OMA; LTNPKGH; -.
DR OrthoDB; 1583928at2759; -.
DR BioGRID-ORCS; 70045; 4 hits in 73 CRISPR screens.
DR PRO; PR:A0A0B4J1N3; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; A0A0B4J1N3; protein.
DR Bgee; ENSMUSG00000096001; Expressed in right colon and 86 other tissues.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IDA:UniProtKB.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISS:UniProtKB.
DR GO; GO:0048018; F:receptor ligand activity; ISO:MGI.
DR GO; GO:0050832; P:defense response to fungus; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IDA:UniProtKB.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; ISO:MGI.
DR GO; GO:0051782; P:negative regulation of cell division; ISO:MGI.
DR GO; GO:2000404; P:regulation of T cell migration; ISS:UniProtKB.
DR InterPro; IPR031713; GPR15L.
DR Pfam; PF15854; GPR15L; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Chemotaxis; Cytokine; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250|UniProtKB:Q6UWK7"
FT CHAIN 25..78
FT /note="Protein GPR15L"
FT /id="PRO_5010906477"
FT DISULFID 37..60
FT /evidence="ECO:0000250|UniProtKB:I3LGZ3"
FT DISULFID 38..57
FT /evidence="ECO:0000250|UniProtKB:I3LGZ3"
SQ SEQUENCE 78 AA; 8899 MW; 279B08C4CF30CEC1 CRC64;
MRLLALSGLL CMLLLCFCIF SSEGRRHPAK SLKLRRCCHL SPRSKLTTWK GNHTRPCRLC
RNKLPVKSWV VPGALPQI
